色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)是一种分泌蛋白,相对分子量为50000,属于丝氨酸超家族的一员。近年来大量研究发现PEDF具有多种生物学功效,包括抗新生血管、神经营养及神经保护功能。PEDF是最有效的内源性眼部新生血管抑制物。PEDF对于治疗血管增生性疾病及视网膜变性疾病具有广阔的前景,就近年来关于PEDF的研究进展及其与脉络膜新生血管性疾病的相关研究进展给以综述。

·Pigment epithelium-derived factor(PEDF)is a relative molecular weight 50 000 secreting protein and a member of the serp in super-family.Recent studies demonstrated that PEDF has multiple biological functions,including antiangiogenic,neurotrophic and neuroprotective properties.It has recently been shown that PEDF is the most potential endogenous inhibitor of angiogenesis in eyes.PEDF has a wide prospect for treatment of human neovascular diseases and retinal degenerative diseases.Finding of PEDF brings new hope for treatment of neovascular diseases.Research progresses in PEDF and the relations between PEDF and choroidal neovascular diseases are reviewed.·

R774.1

中国云南省昆明医学院研究生创新基金资助项目~~