轴突和神经退行性变被认为是多发性硬化症(multiplesclerosis,MS)的伴随特点而且与该病造成终身残疾的病理过程相关。视网膜是缺乏髓鞘但包含神经节细胞及其相关的神经轴突的独一无二的中枢神经系统。因此,它是一个神经退行性变、视神经保护,甚至是潜在的视神经再生的理想可视化的结构。特别是应用于疾病进程进行视网膜具体性的中枢神经系统研究。光学相干断层成像技术(optical coherence tomography,OCT)作为一种光学诊断技术从20世纪90年代中期开始用于眼科临床,它可以以快速,重现的方式对视网膜解剖结构提供高分辨率的重建,那么OCT就可以在多发性硬化的病程中建立一种理想的、精确的模型。我们就OCT在MS患者视网膜神经纤维层的应用现状及研究进展予以综述。

·Axonal and neuronal degeneration seem to be concomitant features of multiple sclerosis(MS)and are probably the pathological processes responsible for permanent disability in this disease.The retina is unique within the central nervous system(CNS)in that it contains axons and glia but no myelin,and it is,therefore,an ideal structure within which to visualize the processes of neurodegeneration,neuroprotection,and potentially even neurorestoration.In particular,the retina enables us to investigate a specific compartment of the CNS which is targeted by the disease process.Optical coherence tomography(OCT)as a kind of optical diagnosis technique has been used for clinical ophthalmology since the middle of 1990s.OCT can provide high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and,we believe,is ideal for precisely modeling the disease process in MS.In this review,we presents the current applications and research progression of the retinal nerve fibre layer in MS using OCT.·

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