目的:观察1g/L普拉洛芬滴眼液控制干眼症患者眼表炎症的疗效和安全性。方法:选择我院2008-04/2008-10门诊诊断为干眼症的患者60眼,随机分成两组,A组为试验组:1g/L普拉洛芬滴眼液及人工泪液联合应用,4次/d点眼,每次1滴。B组为对照组:人工泪液单独应用,4次/d点眼,每次1滴。试验疗程为14d。所有的患者符合入选标准,用药后3,7,14d观察患者的自觉症状、体征、泪膜破裂时间(BUT)、SchirmerⅠ试验、荧光素染色评分等。比较两组的结果,进行统计分析。结果:1g/L普拉洛芬滴眼液及人工泪液联合应用治疗干眼症患者的效果明显优于单纯使用人工泪液治疗组,两组结果有统计学差异。结论:普拉洛芬可以有效控制干眼症患者眼表炎症,是辅助治疗干眼症的有效药物。

·AIM:To observe the efficiency and safety of 1g/L pranoprofen eye drop in dry eye patients with ocular surface inflammation.·METHODS:Sixty dry eye patients of our hospital from April 2008 to October 2008 were randomly divided into two groups,A group:1g/L pranoprofen combined with application of artificial tears eye drops,4 times per day.B group was the control group:artificial tears alone,4 times per day.Experimental treatment lasted for 14 days.All patients met the inclusion criteria,and the patients symptoms,signs,tear film break-up time(BUT),Schirmer Ⅰ test,fluorescein staining score and so on at 3,7,14 days after treatment were observed.Then the results of the two groups were compared and statistical analysis was carried out.·RESULTS:The effect of 1g/L pranoprofen combined with application of artificial tears eye drops in treatment of dry eye patients was superior to the effect of artificial tears alone,results of two groups were statistically significant at the 14th day.·CONCLUSION:Pranoprofen can effectively control ocular inflammation in patients with dry eye,and it is an effective drug in adjuvant treatment of dry eye syndrome.·

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