目的:研究干眼症对比敏感度的变化及通过对比敏感度测试来评价人工泪液对干眼症患者视功能的影响。方法:确诊为干眼症患者25例50眼和正常人15例29眼,分别测量BUT(泪膜破裂时间)、SⅠt(泪液分泌基础实验)和泪膜干涉图像,并采用OPTEC6500视功能测试仪分别测量干眼症患者和正常人应用人工泪液前后的对比敏感度。主要观察指标包括BUT、SⅠt、泪膜干涉图像及低、中、高频CS。结果:本研究中按临床症状、BUT,SⅠt和泪膜干涉图像试验结果将受试者分为干眼症组和正常对照组,两组年龄比较无统计学差异。干眼症患者低、中、高频CS均低于正常组(P<0.05)。应用人工泪液5min后,发现干眼症组低、中、高频CS都有显著提高(P<0.05);且干眼症组应用人工泪液后的对比敏感度与对照组相近。结论:干眼症的低对比敏感度可以通过人工泪液的使用加以改善,通过人工泪液治疗不但可以缓解症状而且使干眼症的视觉质量接近正常人标准;另外,对比敏感度测试可以作为一种客观的非接触的评价泪膜质量的方法,为干眼症的治疗疗效提供客观依据。

·AIM:To study the changes of contrast sensitivity in dry eyes and evaluate the effects of artificial tear application on visual function in dry eyes.·METHODS:The study comprised volunteers in whom dry eye had been diagnosed,and normal subjects which were diagnosed.Their Schirmer’s Ⅰ teat(SⅠt),tear film break-up(BUT)and tear film interference pattern results were collected.All patients were given a contrast sensitivity testing at low,moderate,high spatial frequencies with the OPTEC 6500.BUT,SⅠt,tear film interference pattern,low,moderate,and high score were collected.·RESULTS:The eyes were classified by the diagnosis,based on the symptoms of dry eye,SⅠt,BUT and tear film interference pattern.There were no significant differences in the mean ages of two groups.Contrast sensitivity score in the dry eye group at low,moderate and high frequencies was higher than that of the control group(P<0.05).In the dry eye group,there was a statistically significant increase in contrast sensitivity scores at low,moderate and high frequencies after application of artificial tears(P<0.05).There was no significant change in dry eye group after application of artificial tears with the control group.·CONCLUSION:The decreased contrast sensitivity in dry eyes improves with application of artificial tears.Therefore,the impeded quality of vision seen in dry eye patient could be restored close to normal with artificial tear therapy.Besides,contrast sensitivity test can be used as an objective evaluation of non-contact method of tear film quality,and can provide an objective basis for therapeutic effects of dry eyes.·

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中国辽宁省自然科学基金项目(No.20092101);中国辽宁省教育厅重点实验室基金项目(No.2009S111)~~