目的:观察白蒺藜皂苷(gross saponins from tribulus terrestrisL,GSTT)及灯盏细辛注射液[Erigeron Breviscapus(Vant.)Hand-Mazz,EBHM]对慢性高眼压模型兔视网膜神经节细胞(retinal ganglion cells,RGCs)的保护作用。方法:健康新西兰白兔24只,随机分为对照组、高眼压组、EBHM治疗组和GSTT治疗组,高眼压组和EBHM治疗组及GSTT治疗组的兔眼前房内注射20g/L甲基纤维素制成慢性高眼压模型,EBHM治疗组的兔每日耳缘ivEBHM注射液4.5mg/kg,GSTT治疗组的兔每日耳缘iv GSTT注射液5mg/kg,高眼压持续4wk时,处死实验兔,摘取眼球,做RGCs电镜检查。结果:造模后各组眼压均升高,电镜下高眼压组相对于GSTT治疗组及EBHM注射液治疗组,RGCs超微结构有明显损伤。结论:GSTT及EBHM注射液对慢性高眼压兔RGCs均具有保护作用。

·AIM:To study the protective effect of gross saponins from tribulus terrestris L(GSTT)and Erigeron Breviscapus(Vant.)Hand-Mazz(EBHM)on retinal ganglion cells(RGCs)in rabbits of chronic high intraocular pressure(HIOP)mode 1.·METHODS:Twenty-four rabbits were randomly divided into control group,HIOP group,EBHM treated group,GSTT treated group.The HIOP models were made by injected 20g/L methylcellulose into anterior chamber in rabbits of HIOP group and two treated groups.The rabbits in two treated groups were treated with EBHM and GSTT extract every day,4.5mg/kg and 5mg/kg respectively.When the HIOP lasted for four weeks,killing rabbits,removal of the eye,electron microscopy of RGCs were done.·RESULTS:After modeling in each group were elevated intraocular pressure,ultrastructure of RGCs have obvious damage under electron microscope for HIOP group in relation to the two treatment groups.·CONCLUSION:GSTT and EBHM have a protective effect on RGCs in rabbits with chronic high intraocular pressure.·

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