糖尿病是一种复杂的异质性疾病,目前世界各地有超过一亿人感染此病,造成极其严重社会和经济问题。自然发病的糖尿病啮齿动物模型对于糖尿病发病机制,糖尿病并发症和增加糖尿病危险性的遗传或环境影响等的研究有着无可比拟的重要作用。我们综述了与糖尿病视网膜病变相关的自然发病啮齿动物模型的发生发展和其特性特点。

·Diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socio-economic problems.Spontaneous rodent models of diabetes mellitus have proved invaluable in understanding the pathogenesis,complications,and genetic or environmental influences that increase the risks of diabetes.We have reviewed here in the development and characterization of spontaneous rodent models that displayed most features commonly associated with diabetic retinopathy.·