圆锥角膜患者健康同胞的角膜地形图变化(英文)

Corneal topographic changes in healthy siblings of patients with keratoconus

摘要:

目的:描述圆锥角膜(KCN)患者亲属的受累角膜地形图。方法:对75名KCN患者的150名同胞的300只眼睛在角膜诊所进行了研究,经过完整的裂隙灯,屈光检查并由角膜摄影视频图片提供角膜地形图。进行方差分析,Fisher精确测试和卡方检验比较结果。结果:在150个同胞中,女56%,男44%,平均年龄21(15-39)岁。诊断KCN和可疑KCN的分别为12.3%和6.6%。KCN患者中央角膜曲率(CK)为46.50±4.51(D)而可疑KCN患者为45.66±1.52(D)。KCN患者角膜下方与上方平均屈光度差值(I-S)为3.51±2.50(D)而在可疑KCN患者为1.56±1.22(D)。在KCN状态椭圆型为67.6%(25例)而圆型为32.4%(12例)。在可疑KCN分别为90%和10%。KCN屈光不正为-7.50至1.25(-1.25±1.83)D,可疑KCN为0.45至-4.2(-0.68±0.76)D而健康组为2.75至-7.5(-0.6±1.12)D。KCN和可疑KCN中22.7%为轻度散光,18.3%为中度散光。结论:KCN患者健康同胞中KCN情况增加显示出需要筛选检查以早期诊断并在这些个体中谨慎实施屈光性角膜手术或隐形眼镜治疗。

Abstract:

AIM:To describe the involvement in relatives of kera-toconus (KCN) patients with corneal topography map.·METHODS:A total of 300 eyes of 150 siblings of 75 KCN patients referred to corneal clinic were studied and experienced complete slit-lamp,refraction examinations and topographic cornea maps provided by videophoto-keratography.ANOVA,Fisher exact and Chi-square tests were performed to compare the results.·RESULTS:From 150 siblings,56% were female and 44% were male with average age of 21 (range of 15-39) years old.KCN and suspect KCN diagnosed in 12.3% and 6.6% respectively.The central keratometry (CK) was 46.50±4.51 dioptr(D) in KCN and 45.66±1.52 (D) in suspect KCN.Inferior-superior value (I-S) was 3.51±2.50(D) in KCN and 1.56±1.22 (D) in suspect KCN.In KCN condition the oval pattern was 67.6% (n=25) and round pattern detected was 32.4% (n=12).In suspect KCN these patterns detected were 90% and 10% respectively.Refractive errors in KCN were-7.50 to +1.25D(-1.25±1.83),in suspect KCN 0.45 to-4.2D(-0.68±0.76) and in healthy group 2.75 to-7.5D(-0.6±1.12).Astigmatism was mild in 22.7%,moderate astigmatism in 18.3% in KCN and suspect KCN·CONCLUSION:Increase KCN condition in healthy siblings of KCN patients shows require of screening to early diagnose and cautious treatment of contact lens in these individuals.