2023/11/2 8:57:11 2023/11/1 15:22:12 5 times were classified as group C, a total of 25 patients (25 eyes) , and 25 opposite eyes were randomly selected as control group A. OCTA was used to scan the macular area in 3mm?3mm mode to collect retinal capillary plexus blood flow image, the central macular thickness (CMT) and FD-300 was obtained. The number of central macular thickness (CMT), best-corrected visual acuity (BCVA) , and FD-300 were compared between the two groups at baseline, 1months, 3 months, 6 months and 12 months after the third injection. Results All of the patients were observed at baseline, 1month, 3month , 6 months and 12 months after the third injection, The difference at various time points of CMT(μm) (B: F=79.57, P＜0.01, C: F=85.36, P＜0.01), CMT after treatment at each time point was compared with baseline, the difference between each group was statistically significant (B: t=4.08, 7.57, 5.10, 6.37, P=0.00, 0.02, 0.01, 0.00, C组: t=6.52, 4.71, 3.71, 5.12, P= 0.03, 0.00, 0.00, 0.02). The difference at various time points of BCVA (LogMAR) were statistically significant (B: F=68.73, P＜0.01, C: F=73.85, P＜0.01), BCVA (LogMAR) after treatment at each time point was compared with baseline, the difference between each group was statistically significant (B：t=5.27, 6.28, 8.03, 6.35, P=0.03, 0.00, 0.01, 0.00, C: t=5.11, 4.73, 3.69, 3.95, P=0.02, 0.03, 0.01, 0.02).The difference at various time points of FD-300 were statistically significant (B: F=69.78, P＜0.01, C: F=70.06, P＜0.01), FD-300 after treatment at each time point was compared with baseline, the difference between each group was statistically significant (B: t=4.58, 5.17, 3.87, 4.69, P=0.02、0.00, 0.01, 0.01, C: t=4.87、5.61、6.97, 3.95, P= 0.00, 0.03, 0.00, 0.01). The change of BCVA was positively correlated with the baseline FD-300 and CMT (B: r=0.77, 0.70, P=0.00, 0.00, C：r=0.89, 0.78, P=0.00, 0.00). The number of injections was negatively correlated with the baseline FD-300 (B: r=-0.71, P= 0.00, C: r=-0.63, P= 0.00) Conclusion: The FD-300 parameter of OCTA reflects the state of abnormal perfusion or abnormal telangiectasia around the foveal avascular zone, which is more sensitive than other quantitative parameters, and may be closely related to repeated macular edema, which has important clinical value. Key words: branch retinal vein occlusion, macular edema, conbercept,FD-300 BRVO是一种因静脉回流障碍而出现的视网膜出血及黄斑水肿的视网膜血管性疾病，其中ME是导致视力损害的主要原因[1-2]。目前玻璃体腔内抗VEGF注射治疗是治疗ME的首选治疗方案[3-4]。既往根据FFA表现将BRVO分为缺血型或非缺血型，并判断是否存在黄斑水肿和缺血。但由于FFA无法分层观察且存在染料渗漏的影响 [5]，往往会干扰对于视网膜微血管的观察。OCTA无需造影剂即可安全的评估视网膜微血管[6]。通过对视网膜浅层和深层毛细血管成像，可以清晰显示黄斑中心无血管区以及血流密度等信息[7-8]。本研究旨在通过对非缺血型BRVO合并ME患者黄斑区FD-300的研究，探讨并评估该参数对视力恢复的预测意义及对眼内注药次数的预测作用。]]> 2023/11/1 10:11:58 2023/10/30 16:41:00 2023/10/30 9:58:51 2023/10/30 9:39:16 2023/10/27 11:25:34 2023/10/27 11:01:03 2023/10/26 9:19:22 2023/10/26 9:09:52 2023/10/25 9:22:01 2023/10/24 14:40:15 2023/10/24 8:58:08 2023/10/20 9:27:19 2023/10/19 14:00:44 mild to moderate > control group (P < 0.05); There was a positive correlation between RNFL and MRT in children with amblyopia (r1=0.745, P1 < 0.001; r2=0.724, P2 < 0.001); In mild to moderate and severe patients, there were statistically significant differences in age, fixation form, treatment compliance, RNFL, MRT and their differences between effective and ineffective subgroups at the beginning of treatment (all P < 0.05). Logistic regression showed that age of initial treatment, fixation nature, treatment compliance, RNFL after 1 month of treatment, MRT after 1 month of treatment were the influential factors for the efficacy of children with amblyopia (all P < 0.05). After 1 month of treatment, the combined prediction of RNFL and MRT was significantly better than that of single prediction in children with mild to severe amblyopia. Conclusion There are differences in RNFL and MRT in children with abnormal refractive amblyopia, and they are closely related to the different degrees and curative effects of children. The combination of RNFL and MRT after 1 month of treatment has certain reference value in predicting children with different degrees of abnormal refractive amblyopia.]]> 2023/10/11 15:12:59 2023/10/8 17:17:18 2023/10/8 14:18:09 2023/10/7 10:43:04 0.05). In the non-rapid progression group, axial growth of cases aged 7-12 years was higher than those aged 13-16 years (P < 0.05), but there was no significant difference among different diopters (P > 0.05). Conclusion: Orthokeratology lens is more effective than peripheral defocus spectacles in controlling axial growth in children and adolescents with myopia, and the control effect of orthokeratology lens on rapid-progressing myopia is remarkable.]]> 2023/10/7 10:39:28 2023/10/7 10:38:45 2023/10/7 9:24:54 2023/9/28 11:11:54 2023/9/26 11:07:08 2023/9/26 11:06:06 2023/9/26 9:56:59 2023/9/25 10:43:49 2023/9/22 8:54:09 2023/9/22 8:36:34 2023/9/20 10:13:44 2023/9/20 10:03:05 2023/9/20 10:03:03 2023/9/20 9:05:58 2023/9/19 9:08:26 2023/9/19 8:54:22 2023/9/19 8:48:35 2023/9/18 15:32:49 2023/8/30 9:31:28 2023/8/29 16:26:43 2023/8/29 10:10:41 2023/8/28 11:39:00 0.05), but some cells showed interstitial cell morphology. (2) Immunofluorescence assay showed that compared with the normal oxygen culture group, with the prolongation of hypoxia time, the average fluorescence intensity of Wnt3a protein expression gradually increased, and the intracellular distribution increased significantly. (3) Immunofluorescence assay showed that compared with the normal oxygen culture group, the expression of Dickkopf-1 protein was up-regulated with the prolongation of hypoxia time, the fluorescence expression was weakly positive. (4) Immunofluorescence assay showed that β-catenin protein was almost all located in the cytoplasm of the normal oxygen culture group. After 6 hours of hypoxia treatment, the expression of β-catenin protein increased in the cytoplasm and membrane, and continued hypoxia treatment for 24 hours later, β-catenin protein was significantly up-regulated and gradually transferred to the nucleus. With the extension of hypoxia treatment time, the accumulation in the nucleus gradually increased. After 48 hours of hypoxia treatment, β-catenin protein was expressed in cytoplasm, cell membrane and nucleus. (5) Real-time fluorescence quantitative PCR showed that Dickkopf-1 mRNA only slightly increased in hypoxia 6h group compared with normal oxygen culture group, the difference was not statistically significant (P>0.05). But the expression of Dickkopf-1 mRNA in 12h, 24h and 48h hypoxia group increased significantly (P < 0.05). Conclusion: (1) Hypoxia can induce the activation of Wnt/β-catenin pathway in lens epithelial cells and participate in the EMT of lens epithelial cells. (2) Hypoxia can induce the expression of Dickkopf-1 in lens epithelial cells, regulate the Wnt/β-catenin pathway of lens epithelial cells, and affect the EMT process of lens epithelial cells.]]> 2023/8/25 16:31:32 2023/8/25 9:09:42 -6D) and severe high myopia (≤-8D). IOP and CCT were both important factors affecting corneal biomechanics. Some of the biomechanical parameters and AL also have some correlation, as the axis of the eye grows, the larger the corneal deformation range PD,HCR becomes larger and IR becomes smaller. However, the latter two are not significant, and the clinical attention should be paid to corneal biomechanical parameters in patients with severe myopia.]]> 2023/8/24 10:26:25 2023/8/24 9:05:51 0.05).After treatment, the symptom scores and physical sign scores of patients in the two groups continued to decrease, non-invasive tear break-up time and thickness of tear film lipid layer continued to increase, The density of the meibomian gland also increased. The height of the tear river in the observation group increased, while the control group showed no significant changes. The observation group had better clinical indicators than the control group, and the difference was statistically significant (P<0.05). No obvious complications were observed in all patients. Conclusion: The combination of 3% diquafosol sodium eye drops and instense pulsed light is synergistic in the treatment of meibomian gland dysfunction, with significant therapeutic effects and can promote meibomian gland repair, which is significantly superior to simple intense pulsed light therapy. Key words: Diquafosol; intense pulsed light; meibomian gland dysfunction; meibomian gland density]]> 2023/8/23 17:22:03 0.05). After 6 months of surgery, patients with intermittent exotropia achieved significant improvement in binocular visual function while correcting their eye position. Group A was superior to Group B in terms of fusion range and near stereoscopic visual function, with statistically significant differences (P<0.05).There was no statistically significant difference between the two groups in terms of simultaneous vision and synoptic stereoscopic visual function (P>0.05). CONCLUSION: The binocular visual function of patients with intermittent exotropia after surgery has significantly improved compared to before surgery. Wearing orthokeratology lens can effectively improve binocular visual function in patients with intermittent exotropia combined with myopia after surgery.]]> 2023/8/22 15:38:34 2023/8/22 9:18:31 2023/8/21 16:32:29 2023/8/21 14:08:25 2023/8/16 11:25:54 2023/8/15 11:33:10 2023/8/15 9:57:45 2023/8/14 15:37:41 2023/8/10 9:17:56 0.05). At the end of the experiment, compared with the control group, the mice in the model group and the Chinese medicine group had lower eye diopter and longer axis (p＜0.05), while the mice in the Chinese medicine group had significantly lower eye axis and higher diopter than the model group (p＜0.05). Western Blot and q-PCR results showed that the relative expression of MFN1 and OPA1 decreased and DRP1 increased in both the model group and the herbal group compared with the control group (p < 0.05),and the relative expression of MFN1 and OPA1 increased in the Chinese medicine group compared with the model group (p < 0.05). The electron microscopic results showed that the mitochondria in the right retina of the mice were only mildly swollen in the Chinese medicine group, while the mitochondria in the model group were obviously swollen and disordered and empty. CONCLUSION: modified Zhujing Pill could protect the retinal mitochondria by regulating the key proteins of mitochondrial dynamics(MFN1, OPA1, and DRP1), and have a protective effect on the retina of axial myopic mice.]]> 2023/8/2 9:25:10 2023/8/1 10:02:28 2023/8/1 9:43:25 2023/8/1 9:27:18 0.05). Compared with those of the same group before wearing lenses, the after wearing lenses for 3 months, 6 months, 9 months and 12 months corneal curvature of the orthopedic lens group were decreased, NIBUT of the orthopedic lens group in the same time was shortened , and Chinese Dry Eye Questionnaire, OSDI scores, SPEED score and DEQ-5 score of the orthopedic lens group in the same time were increased (P<0.05); While the Meibomian gland integrity score in the frame lens group after wearing glasses for 3 months, 6 months, 9 months and 12 months were increased (P<0.05). The at wearing glasses for 12 months nibut of children aged 8-12 years in the corneal shaping lens group was shorter than those of children aged 13-15 and 16-18 years in the same group, and shorter than that of children aged 8-12 years in the frame lens group (P<0.05). There was no significant difference between the two groups in other ocular surface and meibomian gland function indexes of children aged 8-12, 13-15 and 16-18 after wearing glasses for 12 months (P>0.05). Conclusion Children and adolescents wearing corneal shaping lens can affect the function of ocular surface and meibomian gland. Nibut of adolescents ≤ 12 years old is significantly shortened but There is no difference in the effects of other ocular surface and meibomian gland of children of different ages. Adolescents ≤ 12 years old were better not to wear corneal shaping lens too early for intervention.]]> 2023/7/31 9:51:55 0.05); compared with before operation, the visual acuity of the two groups increased at 3 months and 6 months after operation (P<0.05), and compared with the control group at 3 months and 6 months after operation, the observation group was obviously better (P<0.05); the cylindrical power, central corneal thickness, ablation thickness, 6A, CV, ECD, IOPg, CH, CRF, and IOPcc of the two groups decreased at 3 months and 6 months after operation (P<0.05), and compared with the control group at 3 months and 6 months after operation, the observation group was obviously lower (P<0.05); there was no obvious difference in the incidence of complications such as corneal ectasia, dry eye, intraepithelial growth and epithelial loss between the two groups (P>0.05). Conclusion SMILE can effectively improve corneal biomechanics and central corneal endothelial cell indexes in patients with high astigmatism, and improve visual acuity, which is safe and effective.]]> 2023/7/31 9:23:32 2023/7/28 11:19:37 2023/7/28 9:34:33 0.05). IMH of 82 patients was closed after surgery, and there were 72 cases in type I closure group and 10 cases in type II closure group. The MHI of type I closure group before surgery was significantly higher than that of type II closure group (P<0.05), and ELM defect diameter before surgery was shorter than that of type II closure group (P<0.05). Spearman rank correlation coefficient analysis showed that IMH closure at 3 months after surgery was positively correlated with preoperative ELM defect diameter (r=0.315, P<0.05), and was significantly negatively correlated with preoperative MHI (r=-0.378, P<0.05). Among the 82 patients, 67 cases with postoperative visual acuity improvement were included in good visual acuity group, and 15 cases with stable visual acuity or decreased visual acuity were enrolled as poor visual acuity group. LogMAR BCVA at 3 months after surgery and defect diameters of ELM and IS/OS before surgery and at 3 months after surgery were significantly lower or shorter in good visual acuity improvement group than those in poor visual acuity improvement group (P<0.05), and the preoperative MHI was significantly higher than that in poor visual acuity improvement group (P<0.05). Pearson correlation coefficient analysis showed that the increase in the number of BCVA lines at 3 months after surgery was significantly positively correlated with preoperative MHI (r=0.796, P<0.05), and was negatively correlated with LogMAR BCVA at 3 months after surgery, ELM defect diameters before surgery and at 3 months after surgery and IS/OS defect diameters before surgery and at 3 months after surgery (r=-0.693, -0.452, -0.396, -0.427, -0.385, P<0.05). Logistics regression analysis revealed that preoperative MHI≥0.5 was a risk factor affecting poor postoperative visual acuity improvement (OR=3.404, P<0.05). Conclusion SD-OCT can predict the surgical efficacy by detecting the MHI before surgery and the defect diameters of ELM and IS/OS before and after surgery, and it is beneficial to judging the improvement of visual function.]]> 2023/7/28 9:11:00 2023/7/27 10:53:19 2023/7/27 9:17:37 2023/7/26 17:02:56 2023/7/26 9:16:35 2023/7/25 9:15:17 2023/7/25 8:55:01 2023/7/24 11:39:22 2023/7/24 11:19:47 2023/7/21 16:37:26 2023/7/20 9:04:50 2023/7/17 9:44:31 2023/7/14 9:30:26 2023/7/14 9:24:49 2023/7/12 14:12:35 2023/7/12 14:12:14 0.05). After 14 days of modeling, when compared with the blank group, FDM group exhibited an increase in the degree of myopia in the right eye, a prolongation of the eye axis, a decrease in the content of DA in the retina, and an increase in the expression of MMP-2, TGF-β2, and α-SMA in the sclera. Conversely, the expression of TIMP-2 and TGF-β1 were decreased（P＜0.01）. However, in comparison to the FDM group, the degree of myopia in the 1ng, 5ng, and 10ng groups of guinea pigs decreased, the eye axis shortened, the content of DA in the retina increased, and the expression of MMP-2, TGF-β2, and α-SMA in the sclera decreased. Furthermore, the expression of TIMP-2 and TGF-β1 in the sclera increased（P＜0.01）. As the concentration of intravitreal injection of VEGF-A165 increased, the degree of myopia in the right eye of guinea pigs gradually increased, and the eye axis gradually prolonged. The content of DA in the retina decreased gradually, the expression of MMP-2, TGF-β2, and α-SMA in the sclera increased gradually, and the expression of TIMP-2 and TGF-β1 decreased gradually. CONCLUSION Intravitreal injection of VEGF-A165 can increase the content of DA in the retina of FDM guinea pigs, affect the expression of MMP-2, TIMP-2, TGF-β1, TGF-β2 and α-SMA in the sclera, and inhibit scleral remodeling of guinea pigs. Notably, the VEGF-A165 of 1ng showed the most significant effect.]]> 2023/7/12 14:11:51 2023/7/10 10:15:16 2023/7/7 10:27:50 0.05). There were significant differences in CT among normal, mild and moderate to severe renal function groups (P<0.05). It was no statistical significance in age, axial length and the course of disease between the two groups(P>0.05). There were significant differences in creatinine, Glomerular Filtration Rate (eGFR), uric acid, urea, potassium and β2-microglobulin between the pachychoroid group and the leptochoroid group (P<0.05). There were no significant differences in total cholesterol, triglyceride, HDL, LDL, Glycosylated Hemoglobin (HbA1c) and glucose between the two groups (P>0.05). CT was negatively correlated with creatinine, urea, uric acid and β2-microglobulin, and positively correlated with eGFR. Multiple regression analysis showed that the thicker the nasal 0.5mm CT, the higher the eGFR (B=0.292, P<0.001). CT affected creatinine, eGFR, urea, uric acid and β2-microglobulin (R2=16.5, 64.6, 24.1, 18.1, 20.3; P=0.008, <0.001, <0.001, 0.004, 0.001) significantly, while there were no significant effects on total cholesterol, triglyceride, glucose, serum calcium, HDL and LDL (P>0.05). Conclusion In patients with naïve-treatment NPDR, the thicker the CT, the better the renal function. The decrease of CT in newly diagnosed NPDR patients is an important hint to pay attention to the renal function.]]> 2023/7/7 9:35:12 2023/7/6 16:15:38 2023/7/6 13:58:49 2023/7/6 9:18:18 2023/7/4 10:01:33 2023/7/4 9:59:07 24 mm group. The uncorrected far vision and the best corrected far vision of the patients before surgery were recorded. The lens thickness was measured with A-ultrasound, and the axial data of the patients were measured with IOL Master The white to white distance of the limbus and the astigmatism of the cornea. The best corrected far vision, corneal astigmatism and rotation degree of implanted TIOL were compared between the two groups 3 months after operation. Spearman test was used to analyze the correlation between IOL rotation stability and related indexes. Results: The white to white distance of corneal limbus in the eye axis ≤ 24 mm group was significantly lower than that in the eye axis>24 mm group, and the diopter of TIOL implantation was significantly higher than that in the eye axis>24 mm group, with a statistically significant difference (P<0.05). BCDVA of the two groups after operation was significantly lower than that before operation (P<0.05), but there was no significant difference between the two groups after operation (P>0.05). The postoperative astigmatism of the two groups was significantly lower than that before surgery (P<0.05), but there was no significant difference between the two groups (P>0.05). The degree of rotation of TIOL in the eye axis ≤ 24 mm group and the eye axis>24 mm group were 5.24 ? 3.72 and 6.36 ? 4.21, respectively, and there was no significant difference between the two groups (P>0.05). There was no statistical significance between the degree of rotation of TIOL after surgery and the length of ocular axis (r=-0.031, P=0.751), the distance from white to white of corneal limbus (r=0.073, P=0.523), and the preoperative lens thickness (r=-0.198, P=0.352). Conclusion: Different axial lengths have no significant effect on visual acuity recovery, corneal astigmatism and IOL rotation stability after IOL implantation in cataract patients.]]> 2023/7/3 10:47:15 0.05). Preoperative BCVA (0.38 0.27) and visual acuity remained basically stable during follow-up. At the last follow-up, visual acuity was unchanged or improved is 47 eyes (92.2%). During follow-up, the visual field of all patients was stable without significant progress. CONCLUSION Trabeculectomy for the PG is a safe and effective treatment method, which can effectively control the IOP and stabilize the vision acuity and visual field of PG and relieve the reverse pupil block.]]> 2023/7/3 9:56:15 2023/6/30 9:37:37 2023/6/30 9:23:53 0.05). There were differences in SE, LT, ACD, ACW, AOD500, ARA500, TISA500, TIA500 and CLR among the four groups (all P < 0.01). SE and LT were negatively correlated with AL (r = -0.75, -0.41, all P < 0.01); ACD, ACW and CLR were positively correlated with AL (r = 0.58, 0.45, 0.54, all P < 0.01); AOD500, ARA500, TISA500 and TIA500 were positively correlated with AL (all P < 0.01). ACD and CLR were negatively correlated with SE (r = -0.21, -0.25, all P < 0.01), and LT was positively correlated with SE (r = 0.21, P < 0.05).CONCLUSION: As axial length increases, CCT remains unchanged while the depth and width of the anterior chamber increase. The position of the crystalline lens moves backward and its thickness decreases.]]> 2023/6/29 17:07:24 2023/6/28 9:47:43 2023/6/28 9:41:35 2023/6/27 9:38:32 2023/6/26 9:21:52 2023/6/21 11:08:01 2023/6/19 10:42:30 2023/6/14 15:52:58 10 points) and control group (75 cases, PSQI≤10 points) according to the Pittsburgh Sleep Quality Index (PSQI). Both groups were scored using the Ocular Surface Disease Index (OSDI), underwent meibomian gland-related examinations (eyelid margin morphology, meibomian gland secretion ability, meibomian gland secretion quality score), corneal fluorescein staining (FL) score, Schirmer’s test (SⅠt), tear film break-up time (BUT) was measured, and sleep indicators (sleep quality, sleep latency, subjective sleep quality, sleep time) were evaluated. Results: There were significant differences in OSDI score, FL score, SⅠt, BUT, eyelid margin morphology score, meibomian gland secretion ability score, and meibomian gland secretion quality score between the two groups (P<0.05). In the sleep disorder group, PSQI score, sleep latency score, subjective sleep quality score, and sleep time score were significantly positively correlated with OSDI score, FL score, meibomian gland secretion ability score, and meibomian gland secretion quality score (P<0.05); PSQI score, subjective sleep quality score, and sleep time score were significantly positively correlated with eyelid margin morphology score (P<0.05); PSQI score, sleep latency score, and subjective sleep quality score were significantly negatively correlated with BUT and SⅠt (P<0.05); sleep time score was significantly negatively correlated with BUT (P<0.05); sleep latency score was not significantly correlated with eyelid margin morphology score (P>0.05); sleep time score was not significantly correlated with SⅠt (P>0.05). Conclusion: The ocular surface condition of MGD patients is correlated with multiple sleep quality indicators, and a decline in sleep quality may increase the risk of MGD. Conclusion: The incidence of MGD is related to multiple indicators of sleep quality. Decreased sleep quality can increase the risk of MGD.]]> 2023/6/14 15:52:21 2023/6/14 15:51:44 2023/6/9 16:31:34 2023/6/9 9:06:23 2023/6/9 8:38:13 0.05). There were no significant differences in IL-36α, IL-36β and IL-36γ in Non-oGVHD group at different time points (all at P>0.05), while there were significant differences in IL-36α, IL-36β and IL-36γ in oGVHD group at different time points (all at P<0.05). Compared with Non-oGVHD group, The levels of IL-36α and IL-36β at V0, V1, V2 and V3 and IL-36γ at V3 were significantly increased in oGVHD group, with statistical significance (all at P<0.05).IL-36 (α, β, γ) were positively correlated with OSDI score, Corneal fluorescein staining (FL) and Conjunctival impression cytology (CIC score), and negatively correlated with Tear break-up time(TBUT) and Schirmer test (all at P<0.05).]]> 2023/6/8 14:20:06 2023/6/7 14:23:07 2023/6/7 10:52:32 2023/6/7 9:04:39 0.05). CONCLUSION: Through this study, the toxic damaging effect of ZnO NPs on the cornea was confirmed from both in vitro and in vivo, which provided a theoretical basis for the ocular safety evaluation of ZnO NPs.]]> 2023/6/6 10:20:07 2023/6/5 17:06:52 2023/6/5 16:44:31 2023/6/5 16:31:04 2023/6/5 9:31:16 2023/6/2 9:42:45 2023/5/31 16:38:35 2023/5/31 10:06:08 2023/5/29 9:59:22 2023/5/29 9:54:17 2023/5/29 9:47:50 2023/5/26 9:28:31 2023/5/25 10:22:12 2023/5/25 10:01:19 2023/5/25 9:44:31 2023/5/15 8:52:44 2023/5/12 16:51:06 0.05). CONCLUSIONS: There are differences in the thickness of the macula and peridiscal RNFL in the amblyopic eye and the contralateral non-amblyopic eye of monocular anisometropic amblyopic children compared with normal eyes, and the contralateral non-amblyopic eye is not completely equal to the normal eye.]]> 2023/5/12 8:52:21 0.05), but there were significant differences in other parameters (all P<0.05).All parameters measured by the two instruments were significantly correlated (all r>0.7, P<0.001).Bland-Altman analysis showed that the refractive power and astigmatism of the anterior cornea surface measured by the two facilities were in good consistency,while the refractive power of the posterior surface and the whole cornea showed poor consistency. CONCLUSION: CASIA2 and IOLMaster 700 exhibited little differences and good consistency in the refractive power and astigmatism of the anterior corneal surface in cataract patients,which seems Interchangeable.However, the refractive power of the posterior surface and the whole cornea presented with significant differences and poor consistency, which should not be interchange casually.]]> 2023/5/12 8:49:17 2023/5/12 8:13:04 2023/5/11 9:18:46 2023/5/11 9:12:53 600m is easy to recurrence of macular edema at 3 months. Conclusions: DEX-I were found to be effective in different patterns of RVO-ME. The CME pattern with larger cystoid space may predict a shorter-lasting morphologic efficacy.]]> 2023/5/11 9:12:11 2023/5/11 8:55:02 0.05); compared with before treatment, the serum levels of IL-6, VEGF and BCVA in the two groups were obviously decreased after treatment (P<0.05), but there was no significant difference between the two groups (P>0.05); compared with before treatment, CMT in both groups was obviously decreased after treatment (P<0.05), and compared with ranibizumab group, CMT in conbercept group was obviously decreased (P<0.05); there was no significant difference in the incidence of complications between the two groups (P>0.05); the total effective rate of patients with serous retinal detachment (SRD), cystoid macular edema (CME) and diffuse retinal thickening (DRT) was obviously different (P<0.05), among which DRT had the highest total effective rate and SRD had the lowest total effective rate. Conclusion Both conbercept and ranibizumab in the treatment of DME can effectively improve the clinical symptoms of patients and reduce the inflammatory response, but conbercept can better reduce the level of CMT, and has better treatment effect for DRT-type DME patients.]]> 2023/5/10 16:26:58 2023/5/10 9:32:13 2023/5/6 14:40:24 2023/5/6 8:50:14 0.05). CONCLUSION: The stability of tear film after surgery of PACG and cataract is decreased.The acute attack eye needs 6 months or even longer to recover, and the contralateral eye needs roughly 3 months. KEYWORDS: Glaucoma with cataract; Trabeculectomy; Phacoemulsification; Ocular surface; Tear film break-up time]]> 2023/5/5 9:15:43 2023/5/5 9:11:52 2023/5/5 9:03:46 2023/5/4 10:00:05 2023/4/28 16:08:18 2023/4/28 13:47:22 2023/4/28 10:34:58 2023/4/28 10:14:14 2023/4/27 9:04:21 2023/4/18 10:32:41 0.05). The lipid layer thickness was positively correlated with tear meniscus height (r=0.143, P =0.006). The thinner the lipid layer was, the higher the tear meniscus height was. There was no correlation between lipid layer thickness and the earliest tear film break-up time (r=-0.09, P =0.083), nor was there correlation between tear meniscus height and the earliest tear film break-up time (r=0.038, P =0.460).Conclusion：Knowing from this study,the differences of tear meniscus height were statistically significant and the differences of the earliest tear film break-up time were not statistically significant under the conditions of different thickness of the tear film lipid layer,there was not different in tear film stability in dry eye patients.]]> 2023/4/17 9:42:14 2023/4/13 14:18:23 2023/4/12 15:21:44 2023/4/12 14:43:30 0.05). Compared with the DMSO group, the levels of VEGF and NICD expression were significantly decreased (P<0.05) and the ability of cell migration and angiogenesis were also significantly decreased (P<0.01) in the DAPT group. CONCLUSION: METTL3-mediated of m6A methylation modification promotes choroidal neovascularization by regulating the Notch pathway.]]> 2023/4/11 16:22:26 2023/4/11 11:14:21 2023/4/11 10:06:42 2023/4/11 9:04:40 0.05).]]> 2023/4/10 10:30:42 2023/4/6 15:51:14 2023/4/6 8:53:55 0.05); At the PMA of 3 and 6 months of PMA, ACD in ROP group was higher than that in non-ROP group, and LT was lower than that in non-ROP group (P < 0.05); at the PMA of 6 months, AL and VL in ROP group were lower than those in non-ROP group (P < 0.05). AL, ACD, VL were positively correlated with PMA in ROP group and without ROP group, CCT was negatively correlated with PMA; there was a positive correlation between LT and PMA in children without ROP. There was no correlation between LT and BW and PMA in ROP group. Conclusion: The ocular development of children with early ROP (PMA 0 ~ 6 months) treated by intravitreal ranibizumab injection is slower than that of premature infants without ROP, and BW and PMA are the main influencing factors of ocular parameters of premature infants.]]> 2023/4/6 8:40:26 2023/4/6 8:28:00 2023/4/4 11:29:05 2023/4/3 15:56:05 0.05). The best corrected visual acuity of the affected macular eyes in the FCB group was significantly higher (P<0.001) than that in the SB group (P<0.05). Both groups effectively promoted the absorption of subretinal fluid (P<0.05). The FCB group had a significantly shorter operation time 16.50min(12.75,25.00) compared to the SB group 38.00 min(36.25,41.75) (P<0.001). Patients in the FCB group also had significantly lower eyelid swelling and pain symptoms than those in the SB group (P<0.001). The VAS score for pain one day after the operation was significantly lower in the FCB group (1.00, 0.00-2.00) than in the SB group (3.00, 2.00-3.00). Conclusion: FCB is a safe and effective surgical method to treat RRD that can alleviate patient pain. Compared to SB, FCB has a significantly shorter operation time and causes less postoperative adverse reactions in patients.]]> 2023/4/3 10:55:25 2023/4/3 9:43:00 2023/3/31 9:06:39 2023/3/31 9:01:04 2023/3/30 9:45:28 0.05). There were no significant differences in age, gender and exophthalmos between active TAO and inactive TAO (pP>0.05). The length and the area of lacrimal gland were higher in the coronal section than in the axial section in both TAO group and the control group (P<0.05). The area of lacrimal gland was higher in active phase TAO than that in inactive phase TAO, and was higher in inactive phase TAO than that in control group in coronal and axial section (pP <0.000). The length of lacrimal gland in coronal and axial section was higher in the active TAO than that in the inactive TAO and the control group (pP <0.05). The width of lacrimal gland in coronal and axial section was were higher in active TAO and inactive TAO than that in the control group (pP <0.05). Compared with the control group, the maximum T2 value in the active TAO was higher than that in the inactive TAO, and the inactive TAO was higher than that in the control group (pP <0.05). The average T2 value in the active and inactive TAO was were higher than that in the control group (pP <0.05). CAS was positively correlated with lacrimal gland area in axial, coronal section and maximum T2 value (p < 0.000). CONCLUSION: The lacrimal gland is statistically significantly enlarged in TAO, especially in active TAO. The lacrimal gland area in axial, coronal section and maximum T2 value could be potentially utilized as may become valuable radiographic biomarkers for to assessing the activity of quantitatively for TAO.]]> 2023/3/17 11:05:58 2023/3/16 11:21:22 2023/3/16 10:03:57 2023/3/16 9:49:32 -4.00D). Refractive status, corneal morphology, corneal endothelial cells, and visual quality were measured at discontinuation, and 1mo, 2mo and 3mo after discontinuation. The differences between the two groups at each time point, and those before and after wearing lenses were analyzed. RESULTS: There was no statistically significant difference in spherical equivalent or cylindrical power in each group before and after discontinuation (P>0.05). The corneal flat K values, corneal steep K values and corneal average K values of mild group and severe group at discontinuation were lower than those before wearing lenses, and they returned to the state before wearing lenses after 2mo of discontinuation (P>0.05). There was no statistically significant difference in corneal astigmatism, surface regularity index or surface asymmetry index in each group before and after discontinuation (P>0.05). There was no significant change in corneal endothelial cell density of the two groups before and after discontinuation (P>0.05). The proportions of hexagonal cells in the two groups at discontinuation were lower than those before wearing lenses, and returned to the state before wearing lenses after 1mo of discontinuation (P>0.05). The cut-off frequency of modulation transfer function (MTF) was decreased in the two groups at discontinuation, which returned to the state before wearing lenses after 1mo of discontinuation (P>0.05). CONCLUSION: Corneal morphology and corneal endothelial cells can be restored to the state before wearing the orthokeratology lens after 3mo of discontinuation, and the effect of orthokeratology lens on corneal surface morphology is reversible.]]> 2023/3/15 9:25:29 0.05). Compared between groups, the OSI value of EVO-ICL group at each time point after surgery was lower than that of SMILE group, and the MTF cutoff at 1 week after surgery, SR and VA20% at 1 week and 1 month after surgery, and VA9% at each time point after surgery were higher than those of SMILE group(P1=0.002,0.003,0.0.035, P2=0.049, P3=0.002,0.001, P4=0.012,0.009, P5=0.001, <0.001,0.034). The most common postoperative visual symptom in SMILE group was visual haze, and in EVO-ICL group was halo. There was no correlation between the occurrence of visual symptoms and OSI, MTF cutoff, SR, VA and other objective visual quality indicators. Conclusion: SMILE and EVO-ICL have safety, effectiveness and stability in the short time after correction of moderate myopia. EVO-ICL has better objective visual quality in the short term. Both groups have some postoperative subjective visual symptoms, but the overall satisfaction of patients is high.]]> 2023/3/15 9:21:31 0.05). The BCVA of the two groups was significantly improved over time after operation (P<0.05), but there was no significant change in intraocular pressure (P>0.05). There was no statistically significant difference in BCVA or intraocular pressure between the two groups before operation and at 1wk, 1mo, 3mo and 6mo after operation (P>0.05). Complications were observed in the two groups, but there was no statistically significant difference in the incidence of complications between the two groups (P<0.05). CONCLUSION: PPV combined with inverted internal limiting membrane insertion and tamponade is safe and effective in the treatment of high myopia with MHRD, which can effectively improve the patients' BCVA and the hole closure rate, without influence on intraocular pressure.]]> 2023/3/14 9:47:48 2023/3/13 10:07:53 0.05). The correlation between SSI and age, SE, AL, IOP, CCT and other new parameters was analyzed. SSI was positively correlated with age (r=0.102, P=0.006), SE(r=0.361, P<0.001), IOP(r=0.175, P<0.001), CCT (r=0.098, P=0.009), SPA1 (r=0.182, P<0.001), and was negatively correlated with AL(r=-0.331, P<0.001) , IR(r=-0.545, P<0.001).No correlation with other parameters (P>0.05). Conclusion: With the increase of myopia degree and the growth of the axial length, the SSI value becomes smaller and the corneal hardness decreases. SSI may be a useful corneal biomechanical indicator for future myopia research.]]> 2023/3/13 9:30:17 2023/3/9 9:13:56 2023/3/8 10:39:57 2023/3/8 9:01:40 2023/3/7 14:40:43 2023/3/7 10:32:49 2023/3/7 9:11:51 2023/3/6 11:16:59 2023/3/6 10:46:50 1.2 and p<0.05 was used to determine the differentially expressed proteins (DEPs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database were utilized for functional enrichment analysis of the top 50 DEPs with either up-regulated or down-regulated significance, and pathway commons software to establish the protein-protein interaction (PPI) network. RESULTS: Overall, 552 DEPs were identified. Compared with the control group, 176 proteins were up-regulated in the experimental group, including HMGB1 and USP1, while 376 proteins were down-regulated, including POLR2A and POLR2B. GO and KEGG enrichment analysis indicated that the top 50 DEPs with up-regulated or down-regulated significance were involved in various crucial biological processes and signaling pathways. PPI network revealed that oxidative damage repair (ODR)-related proteins might play a key role in UVB-induced oxidative damage. CONCLUSIONS: The expressions of multiple proteins, especially ODR-related proteins, can be altered in SRA01/04 cells via UVB irradiation. These findings may provide cellular insights into the pathogenesis of ARC and into proteins or pathways associated with therapeutic targets.]]> 2023/3/6 9:49:22 2023/3/3 14:36:07 2023/3/2 10:24:19 2023/3/1 13:40:34 2023/3/1 10:08:00 0.05), while the prevalence of astigmatism was higher than that of girls (P<0.001). Spearman correlation analysis showed that axial length, axial length to axial ratio ratio, anterior chamber depth, and pupil diameter were negatively correlated with SE (rs=-0.664, -0.724, -0.320, -0.086, P<0.001), and lens thickness was positively correlated with SE (rs=0.147, P<0.001). Conclusion: The prevalence of myopia among primary and secondary school students in Urumqi is high, and there are differences in the distribution of ocular biological parameters among children and adolescents of different ages and ethnicities. Keywords: Refractive error; Myopia; ocular biological parameters; Urumqi; ethnic group]]> 2023/2/20 10:36:50 2023/2/17 13:46:35 2023/2/15 9:45:31 2023/2/14 10:00:04 2023/2/13 16:07:37 2023/2/13 15:37:24 NDR group>NPDR group>PDR group, difference was statistically significant (P<0.05); the level of serum CTRP9 in non-DME group was higher than that in the DME group, and the difference was statistically significant (P<0.001). Spearman rank correlation analysis showed that the level of serum CTRP9 in DR patients was negatively correlated with the course of diabetes (rs=-0.251, P<0.05); the level of serum CTRP9 in DME patients was negatively correlated with FBG (rs=-0.370, P<0.05) and HbAlc (rs=-0.421, P<0.05). Logistic multivariate regression analysis showed that the course of disease (OR=1.194, 95%CI: 1.068~1.335) and CTRP9 (OR=0.936, 95%CI: 0.907~0.966) were the influencing factors of DR (all P<0.05); and CTRP9 was the influencing factor of DME (OR=0.838, 95%CI: 0.778~0.903, P<0.001). ● Conclusion: The reduction of CTRP9 level is a risk factor for the occurrence of DR and DME, which may be of great significance to the risk assessment of both. ● Key words: C1q/tumor necrosis factor related protein 9; diabetes retinopathy; diabetic macular edema]]> 2023/2/13 9:41:08 46D group (12 eyes), 44D < K≤46D group (24 eyes), and K≤44D group (16 eyes). The MAE of SRK/T formula and Haigis formula were significantly higher than those of Barrett Universal Ⅱ formula and Wang-Koch modified SRK/T formula (P < 0.01). According to preoperative axial length (AL), patients were divided into AL≤30mm group (24 eyes) and AL > 30mm group (28 eyes). The MAE of SRK/T formula and Haigis formula in 2 groups were significantly higher than those of Barrett Universal Ⅱ formula and Wang-Koch modified SRK/T formula (P < 0.05). Conclusions: Wang-Koch modified SRK/T formula and Barrett Universal Ⅱ formula are more accurate in predicting the degree of intraocular lens in patients with ultra-high myopia complicated with cataract.]]> 2023/2/13 9:32:37 2023/2/10 15:51:52 0.05). Total ocular astigmatism in the modified group was significantly lower than that in the conventional group (1mo：t=3.884，P＜0.001；3mo：t=3.314，P=0.002). In addition, IOLs tilt and decentration in the modified group were significantly less than that in the conventional group at 1 and 3mo postoperatively (all P>0.05). No significant difference was found in IOL tilt and decentration for intra-group comparison at 1 and 3mo postoperatively (P>0.05). Complications of 55 cases included 2 cases of transient intraocular pressure elevation, 2 cases of transient hypotony which recovered after topical medication and 1 case of vitreous hemorrhage which resolved spontaneously. •CONCLUSION: Intrascleral fixation of posterior IOLs is proved to be a safe and effective surgical technique, with hyperopic shift easily present after operation. Increasing the refractive power of IOLs and targeting mild myopia during IOLs power calculation can prevent postoperative hyperopia, but long-term outcomes still need further observation.]]> 2023/2/10 9:45:47 2023/2/9 14:13:24 2023/2/9 9:23:16 3.4mm). Analyzed differences by one-way ANOVA and LSD-t test were used within the groups and for the entire, researched correlationship of WTW, HCS and VCS within the groups by Pearson and linear regression equation analysis, compared the differences between the groups by one-way ANOVA and LSD-t test. ·RESULTS: The differences between WTW, HCS and VCS had statistical significance within conceptual data and 3 ACD groups, but the difference between WTW and HCS (P＞0.05). Both WTW-VCS and HCS-VCS were statistically significant on their differences (P<0.01).WTW had statistically significance Pearson correlated with HCS and VCS in each 3 ACD groups, yet the linear regression analysis between WTW and VCS in deep ACD group was week(r=0.470，R2=0.221，P=0.007).The differences between the groups were significant statistically shown by one-way ANOVA and LSD-t test (P<0.01). ·CONCLUSION: The WTW was suggested predicting HCS rather than perfectly replacing HCS before patients had the ICL operation among low to moderate myopia eyes. The predictability of VCS would decline as the ACD depth increaseing, calculating VCS with WTW was not recommended.]]> 2023/2/8 9:46:44 2023/2/8 9:32:05 2023/2/7 9:03:00 2023/2/6 9:42:47 2023/2/6 9:30:52 2023/2/3 11:28:35 2023/2/3 9:29:24 2023/2/2 15:37:46 2023/2/2 11:00:10 2023/2/2 9:56:46 2023/1/18 11:17:20 0.05). Compared with 1d after the operation, the scores of subjective symptoms, degree of conjunctival hyperemia, and degree of conjunctival edema decreased significantly in the two groups at 3d, 5d, and 14d after the operation (P<0.05). The above scores and corneal fluorescein staining (FL) scoresof the observation group at 3d, 5d, and 14d after the operation were significantly lower than those of the control group (P<0.05). The proportion of corneal epithelial defect repair time ≤5d in the observation group was significantly higher than that in the control group (P<0.05). The incidences of conjunctival granuloma and symblepharon, and the recurrence rate in the observation group were significantly lower than those in the control group (P<0.05). CONCLUSION: Modified pterygium resection combined with CAT is effective in the treatment of pterygium. It can alleviate postoperative irritative symptoms, conjunctival congestion and conjunctival edema, which is more conducive to postoperative corneal epithelial repair and reduction of postoperative complications and recurrence rate.]]> 2023/1/18 9:42:10 2023/1/17 15:21:45 2023/1/17 14:33:58 2023/1/16 9:55:39 2023/1/16 9:53:31 2023/1/13 15:47:17 2023/1/13 15:23:53 2023/1/13 9:10:54 2023/1/12 16:40:44 0.05). Ks, Kf and Km of posterior corneal surface and whole cornea measured by Scheimpflug anterior segment analyzer were all greater than those by SS-OCT (P<0.05). There was no significant difference in astigmatism and axial values of anterior corneal surface, posterior surface and whole cornea measured by SS-OCT and Scheimpflug anterior segment analyzer (P>0.05). The intra-group correlation coefficient (ICC) values of all parameters were all greater than 0.9, indicating good intra-group repeatability. Ks, Kf, Km, corneal astigmatism and axis of anterior corneal surface, posterior surface and whole cornea measured by SS-OCT were positively correlated with those measured by Scheimpflug anterior segment analyzer (P<0.05). Bland-Altman consistency analysis showed that Ks, Kf, Km, corneal astigmatism and axis of anterior corneal surface, posterior surface and whole cornea measured by SS-OCT were highly consistent with those measured by Scheimpflug anterior segment analyzer (P<0.05). CONCLUSION: The corneal curvature and astigmatism parameters measured by new SS-OCT are highly consistent with those measured by Scheimpflug anterior segment analyzer, which can be applied in diagnosis of corneal curvature and astigmatism in patients with age-related cataract.]]> 2023/1/12 15:35:48 0.05); after 1 w, 1 m and 3 m, visual acuity was significantly higher, the observation group was significantly higher than that, visual field MD was significantly lower, and significantly lower than the control group (P <0.05); The corneal astigmatism AKP ( 0) was significantly lower in the 3 m groups, the observation group was significantly lower than the control group (P <0.05), and no statistical difference in corneal astigmatism AKP ( 45) (P> 0.05); SIT increased first and then decreased, the peak was 1 w; BUT decreased first and then increased, the peak was 1 w.SIT in the observation group (P <0.05) and SIT with the control group (P <0.05). Conclusion: Steep meridian clear corneal incision phacoemulsification surgery is beneficial to improve the postoperative visual function of patients, reduce postoperative corneal astigmatism, reduce the damage to the patient's tear film function, and promote its recovery.]]> 2023/1/11 16:49:25 2023/1/11 10:10:59 2023/1/11 9:20:54 2023/1/10 17:21:23 2023/1/9 10:02:03 2023/1/9 9:51:35 2023/1/9 9:42:06 2023/1/6 10:55:30 △ACD (1.32 times, 1.31 times), and the standardized regression coefficients of group C were △ACD>△AL (1.66 times). Conclusion: Different surgical procedures had no significant effect on the postoperative K and refractive error in patients with axial high myopia combined with cataract, of which main influencing factor is the change in the length of the eye axis before and after surgery. The postoperative refractive error in patients with normal eye axis was more due to the change of anterior chamber depth.]]> 2023/1/5 16:40:29 2023/1/5 9:37:36 2023/1/4 16:07:04 2022/12/15 10:12:12 0.05). CRT of patients in the VMI unchanged group decreased significantly (P=0.039), but there was no significant change in patients in VMI changed group (P=0.627). Logistic regression analysis showed that BCVA was a risk factor for VMI change before treatment (P=0.049, OR=6.210, 95% CI 1.006~38.346). Conclusions: The VMI of DME patients may change during repeated intravitreal injections of anti-VEGF drugs. The worse the BCVA before treatment, the higher the risk of VMI change, and the patients with VMI change have a poor response to anti-VEGF treatment.]]> 2022/12/14 16:52:16 2022/12/14 10:17:12 2022/12/12 11:26:30 0.05). At 1, 3 and 6mo after surgery, anterior capsule area in CTR group was larger than that in control group (P<0.05), and total IOL inclination was significantly lower than that in control group (P<0.05). At 1, 3and 6mo after surgery, scores of subjective visual quality in both groups were decreased (P<0.05), which were higher in CTR group than control group (P<0.05). The total incidence of postoperative complications in CTR group was lower than that in control group (P<0.05). Conclusion: CTR implantation is beneficial to maintain capsular morphology, reduce capsular contraction, stabilize IOL position and improve postoperative visual quality in patients with high myopia, cataract and suspensory ligament relaxation, with fewer complications.]]> 2022/12/12 11:13:12 2022/12/9 16:55:28 2022/12/9 11:10:40 0.05) and sex composition ratio(χ2=0.19, P>0.05).All subjects were scanned by OCTA with HD 4.5mm×4.5mm imaging scanning mode.The ppVD and pRNFL thickness around the optic disc eight areas were measured by the software of device, including temporal superior (TS),superior temporal (ST), superior nasal (SN),nasal superior (NS), nasal inferior(NI),inferior nasal (IN),inferior temporal (IT),and temporal inferior (TI).The characteristic changes of ppVD and pRNFL thickness in the three groups were observed.The canonical correlation analysis were used to analyze the relationships between ppVD and pRNFL thickness in each side. RESULTS: The vessel density (VD) of inside disc,the whole VD of around disc,the peripapillary superior (pS),peripapillary inferior (pI),TI,ST and SN side ppVD of the affected group were all significantly decreased compared with the control group(Z=-3.279、3.309、-3.771、-1.965、-4.347、-2.729，P＜0.05).But only VD of the inside disc in contralateral group was markedly decreased(Z=-2.549,P＜0.05).Compared with the control group，the pRNFL thickness in the TS side of the affected group was increased，and the ST and IT side pRNFL thickness of the contralateral group were decreased. Those differences were statistically significant (Z=-4.14,-3.235,-3.454,P＜0.01).The canonical correlation analysis revealed that ppVD and pRNFL thickness were provided with a strong correlation between the two comprehensive variables.There were 2 pairs of canonical correlation variables in affected group and contralateral group,and 3 pairs of canonical correlation variables in control group. CONCLUSION: The VD in the optic disc area of the affected group was decreased in unilateral RVO,and the pRNFL thickness in ST and IT side of the contralateral group was thinner. There was a strong positive correlation between ppVD and pRNFL thickness as a whole. The changes of ppVD and pRNFL thickness in the optic disc area were mostly manifested in the superior quadrant of the affected group and the inferior quadrant of the contralateral group.]]> 2022/12/9 9:49:55 0.05), 1:1500 for PERK, 1:200 for GRP78, and Caspase-12 at 1:100 showed appropriate intensity of positive expression and statistically significant differences from the rest of positive expression of antibody concentrations (P < 0.05). Conclusion The degree of positive expression of immunohistochemistry in the retina of RP mice was appropriate at antibody concentrations of 1:1000 for IRE1, 1:500 and 1:1000 for ATF6, 1:1500 for PERK, 1:200 for GRP78, and 1:100 for Caspase-12.]]> 2022/12/9 9:11:10 0.05), while the difference was statistically significant in the group greater than 5mm (P<0.05). CONCLUSION: The corneal higher-order aberrations, especially clover aberration and coma aberration, and astigmatism of large meibomian gland cysts after surgical treatment are significantly reduced. It is recommended that patients who plan to undergo refractive surgery should be carefully examined before surgery. For patients with meibomian gland cysts, especially those with lesions larger than 5mm, it is recommended to resect the cysts before refractive surgery. KEYWORDS: chalazion; higher order aberrations；corneal refractive surgery；sirius three-dimensional anterior segment analysis system]]> 2022/12/7 15:57:00 2022/12/7 10:57:10 0.05), but there was difference in cylindrical diopter (P<0.001). Conclusion.The abnormal visual acuity rate of the children aged 3-5 years decreased gradually with the increase of age, and then increased after 6 years old. At 3-6 years ,simple myopic astigmatism was the main refractive abnormality . Attention should be paid to the development of visual acuity in preschool children,and regular visual acuity and refractive status examinations should be carried out.]]> 2022/12/7 10:54:11 2022/12/6 10:27:36 2022/12/5 16:13:00 0.05). In group B, the UIVA at 80cm were significantly better than in group A (P<0.01), while the UNVA in group A and B were no statistically significant differences (P>0.05). The defocus curve analysis revealed that the group A had double peaks (0D and-3D) while the group B had double peaks (0D and-2.5D). Patients in the two groups showed different degrees of halo, glare and other optical phenomenas, but the overall satisfacations and the scores of satisfacations for reading were higher. Conclusion All groups can obtain good near and far distance VA, patients were high spectacle independent after 3 month of surgery. The AtLisa tri 839 MP IOL and 809 MP IOL can provide good near vision, while 839 MP IOL are more suitable for intermediate distance vision.]]> 2022/12/5 9:56:14 2022/12/5 9:40:57 2022/12/2 10:18:38 2022/12/2 9:34:03 2022/12/2 9:10:24 2022/12/1 15:01:28 2022/11/30 9:17:42 2022/11/29 16:52:12 2022/11/17 9:36:25 2022/11/16 10:07:22 2022/11/16 9:20:01 2022/11/14 15:09:40 2022/11/14 9:42:26 2022/11/11 15:31:20 2022/11/11 9:45:06 2022/11/10 15:06:46 0.05). After treatment, there was no significant difference in MVD of SVC layer, choroid layer, and choroidal capillary layer between the two groups (P>0.05). The MVD of DVC layer in group A was significantly greater than that in group B (P<0.05). There was no significant difference in superficial and deep FAZ areas between the two groups before and after treatment (P>0.05). There was no significant difference in the incidences of subconjunctival hemorrhage and eye wear between the two groups (P>0.05), but the incidence of intraocular hypertension in group A was significantly higher than that in group B (P<0.05). There was no significant difference in ME recurrence rate between the two groups (P>0.05), but the average recurrence time of group A was significantly longer than that of group B (P<0.05). CONCLUSION: Compared with ranibizumab, intravitreal dexamethasone implant can better increase the MVD of DVC layer and maintain the effect for a longer time, but there is a higher risk of adverse reactions.]]> 2022/11/10 14:55:57 2022/11/9 13:49:47 2022/11/8 14:25:04 2022/11/8 10:21:02 2022/11/8 9:51:59 2022/11/8 9:37:00 2022/11/8 9:23:03 0.05). At 6mo, the total high order aberration, spherical aberration, and vertical coma in the FS-LASIK group and TransPRK group were significantly higher than those before surgery (all P<0.001), and the total high order aberration and vertical coma in the FS-LASIK group were higher than those in the TransPRK group (all P<0.001). At 6mo, the mean validity index was 1.054±0.172 in the FS-LASIK group and 1.082±0.147 in the TransPRK group, with no significant difference (t=-0.755，P=0.459). At 6mo, the mean safety index of the FS-LASIK group was 1.009±0.114, which was significantly lower than 1.124±0.213 of the TransPRK group (t=-2.322，P=0.033). CONCLUSION: Both FS-LASIK and SPT-guided TransPRK had better postoperative long-term vision. The total high order aberration and vertical coma of patients in the FS-LASIK group were higher than those in the TransPRK group, and the FS-LASIK safety index was lower than that in the TransPRK group. TransPRK is slightly better than FS-LASIK.]]> 2022/11/7 11:27:53 0.05）.In v2、v3，Two groups of patients，OSDI score, eyelid margin score, meibomian gland secretion score,expressibility of meibomian gland excretion score, ocular surface hyperemia,corneal fluorescein sodium staining score were lower than before treatment，NIBUT was increased before treatment，the differences were statistically significant（all P < 0.05）.Comparison between groups, the difference was statistically significant（P < 0.05），In the treatment group,the observation indexes improve more obvious.No obvious complications occurred in all patients. CONCLUSION:IPL comprehensive therapy have better effect in reducing the inflammation of ocular surface，and improving the function of meibomian gland,and it can be used as a new option for physical therapy of blepharokeratoconjunctivitis.]]> 2022/11/7 10:23:46 2022/11/4 10:39:25 2022/11/4 9:47:32 2022/11/4 9:46:33 2022/11/1 14:14:06 2022/10/19 9:37:36 0.05). There was no significant difference between the 2 groups in BUT before operation and on day 7 after operation (P>0.05). The BUT of group B was significantly longer than that of group A on day 30 and day 90 after operation (P<0.05). There was no significant difference between the 2 groups in pain scores at 2h, on day 1 and day 3 after operation (P>0.05). There was no significant difference between the 2 groups in UCVA and the best corrected visual acuity before operation and on day 30 after operation (P>0.05). The UCVA of the 2 groups was significantly improved on day 30 day after operation as compared with that before operation (P<0.05). The disappearance time of ocular hyperemia and edema, and wound healing time of group B were significantly shorter than those of group A (P<0.05). There was no significant difference in the total incidence of complications between the 2 groups (P>0.05). The 1-year recurrence rate of group B was significantly lower than that of group A (P<0.05). CONCLUSION: Compared with pterygium resection combined with frozen amniotic membrane transplantation, pterygium resection combined with fresh amniotic membrane transplantation is more effective in the treatment of primary pterygium. In addition, patients heal faster, and the recurrence rate is lower after the latter operation.]]> 2022/10/18 14:15:34 0.05), and the above parameters gradually returned to the initial state after 10 minutes of distant vision. Conclusion: the physiological and functional parameters of eyes have changed after close reading.It shows the long-term close eye use will lead to changes in various parameters, and then affect eye health in young people.]]> 2022/10/14 9:48:19 2022/10/13 11:19:33 2022/10/13 10:31:14 2022/10/13 10:14:27 300 μm and baseline CNV area > 1.0mm2 were all related factors affecting retreatment. Conclusion Intravitreal injection of ranibizumab 1+PRN and 3+PRN can effectively improve the visual prognosis and anatomical structure of PM-CNV patients, but the 1+PRN treatment has less injection times than the 3+PRN treatment, which reduces the risk and cost of treatment.]]> 2022/10/12 9:19:36 0.05). ②There was no significant difference in operation time, the occurrence of intraoperative hemorrhage, retinal incision and iatrogenic retinal breaks among the three groups (P>0.05). ③ BCVA at 3 and 6mo after surgery was significantly better than that before surgery (P<0.05), and CMT was significantly lower than that before surgery in the three groups (P<0.05), but there was no significant difference among the three groups (P>0.05). Conclusion Intravitreal injection of anti-VEGF drugs before vitrectomy in PDR patients can reduce the expressions of vascular-related factors in aqueous humor. The clinical effect and safety of vitrectomy respectively combined with ranibizumab, conbercept and aflibercept are comparable in the treatment of PDR.]]> 2022/10/11 15:15:55 2022/10/11 11:03:01 0.05). The corneal astigmatism of group A at 1 month and 3 months postoperative, which were not significantly different from preoperative (P>0.05).The corneal astigmatism of group B was 0.66?0.13 and 0.61?0.12 at 1 month and 3 months postoperative, significantly lower than that of 1.34?0.24 preoperative (P<0.05). In group B, there was no significant change in CJ0/CJ45 between 1 month and 3 months postoperative (P>0.05). In group A, CJ0/CJ45 were significantly different from those at 1 month and 3 months postoperative(P<0.05).The Polar K of 1 month and 3 months postoperative in group B were lower than preoperative(P<0.05). The Polar K of group A at 1 month and 3 months postoperative were higher than those of preoperative(P<0.05). HOA of group A and group B at 3 months postoperative was lower than that preoperative (P<0.05). HOA in group B was lower than that in group A 3 months postoperative (P<0.05). The coma at 3 months postoperative in group B was lower than that in preoperative and group A. ? Conclusion: For cataract patients with moderate to low astigmatism, there was no significant difference in postoperative UCVA between double steep axial corneal incisions and normal incision. However, compared with normal incision, double steep axial corneal incisions can lower postoperative HOA and improve postoperative visual quality by reducing corneal astigmatism and coma.]]> 2022/10/10 11:02:33 0.05). The comparison of middle vision under naked eye and best corrected far vision in symfony group was higher than that in zmb00 group; Compared with the near vision under the naked eye and the best corrected far vision, the zmb00 group was higher than the symfony group, and the difference was statistically significant (P < 0.05); There was no significant difference between the two groups (P > 0.05). Three months after operation, symfony group was better than zmb00 group in the +1.0d ~ -3.0d span, and the defocus curve formed a plateau period of slow decline, and the visual acuity was better than 0.3logmar, and in the -1.0d ~ -2.5d span, the difference was statistically significant (P < 0.05); The defocusing curve of zmb00 group was bimodal, with peaks at 0d and -3.5d, and the span of -3.0d ~ -3.5d was better than that of symfony group, and the difference was statistically significant (P < 0.05). The contrast sensitivity (CS) of dark environment spatial frequency (3, 6, 12, 18cpd) in symfony group was better than that in zmb00 group, and the difference was statistically significant (P < 0.05). There was no significant difference in IOL eccentricity, inclination and visual quality score between the two groups three months after operation (P > 0.05). Residual astigmatism tolerance in zmb00 group (+0.75d and -1.00d) and symfony group (+1.00d and -1.50d) showed discomfort and visual acuity lower than 0.3logmar, the difference was statistically significant (P < 0.05). Discomfort such as glare and halo occurred in both groups to varying degrees, but most of the symptoms adapted or disappeared with the passage of time. Conclusion after cataract surgery for high myopia, both IOL have good bag centricity and stability, and can provide excellent visual quality. Symfony IOL can provide effective continuous visual range, with more advantages in medium vision and slightly insufficient performance in near vision, while zmb00 IOL is more suitable for those who have high requirements for close vision, and symfony IOL shows better tolerance to postoperative residual astigmatism.]]> 2022/10/8 11:13:23 2022/10/8 10:06:53 0.05); The cular analysis was all lower than before (t=-8.502，-13.341， P <0.05). Methods 1 (t=-18.011，25.851，-10.676， P <0.05),method 2 t=-13.361,4.584,-6.687， P <0.05). In the severe group, the two treatments changed before and after treatment, and there was no statistically significant difference in the values of method 1 before and after treatment (t=-18.351，6.977，8.989，-2.821， P>0.05), the values of method 2 were significantly improved before and after treatment, except for the height of lacrimal river (t=-15.514，17.926，-14.020，P <0.05). Conclusion Both treatments were effective for moderate meibomian gland dysfunction related dry eyes, while severe meibomian gland dysfunction related dry eyes should be treated with meibomian gland fumigation and massage combined with intense pulse light.]]> 2022/9/30 9:58:48 2022/9/29 17:02:26 2022/9/29 9:58:04 2022/9/29 9:04:14 2022/9/27 16:58:13 2022/9/27 16:13:45 2022/9/27 10:40:50 2022/9/26 9:58:17 2022/9/23 10:40:30 2022/9/23 10:32:47 2022/9/14 10:09:36 0.05). After wearing, the noninvasive keratograph assessment of first and average tear film breakup time (NIKBUT) of the two groups was significantly shortened (P<0.05), but there was no statistically significant difference between the groups (P>0.05). The Schirmer Ⅰ test and tear meniscus height of the two groups showed no statistically significant difference before and after wearing (P>0.05). The incidence rates of complications in the observation group and the control group after wearing were 6.90% and 6.03%, respectively (P>0.05). CONCLUSION: Base curve aspheric orthokeratology is superior to base curve spheric orthokeratology in the treatment of juvenile myopia with moderate to high astigmatism from perspectives of correction effect and objective visual quality. However, the two have similar influence on ocular surface morphology and tears.]]> 2022/9/9 16:35:33 2022/9/9 16:35:11 0.05) . Compared with the blank control group, the serum concentration of Il-17 was increased in all treatment groups except OVA + nebulizer group and RW + subcutaneous group (P < 0.05) . Conclusion: The immune tolerance of allergic conjunctivitis induced by subcutaneous injection of antigen was the most suitable method in the early life of mice.]]> 2022/9/8 10:40:47 2022/9/7 9:17:19 2022/9/6 14:15:00 2022/9/5 15:01:23 2022/9/2 8:38:24 2022/9/1 10:52:00 0.05). The best corrected visual acuity (BCVA), central macular thickness (CMT), subretinal fluid (SRF) height, vessel densities of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP), and area of the foveal avascular zone (FAZ) were collected before and 2 weeks, 1 month, 3 months and 6 months after treatment. Statistical analysis was performed by SPSS 20.0 software. Results The LogMAR BCVA of the two groups were significantly higher than baseline after 3 and 6 months. The CMT was significantly reduced at 2 weeks after treatment in the Navilas group and at 1 month after treatment in the SML group. In both groups, there was significant difference compared with baseline after 3 and 6 months，but there was no significant difference between the two group at 3 and 6 months after treatment. The vessel densities of the SCP and the DCP were not significantly different from baseline at all follow-up visits in both groups. The area of the FAZ was also not significantly different from baseline in the two groups. Conclusion Subthreshold laser photocoagulation with the NAVILAS® Laser system can rapidly improve the retinal morphology, shorten the course of CSC, and recovery the visual function. The advantages of this treatment include rapid effect, high cost-effectiveness, non-invasiveness, and high repeatability for patients with cCSC.]]> 2022/9/1 10:21:35 2022/9/1 10:05:03 2022/9/1 9:59:12 2022/8/30 11:19:36 2022/8/29 16:24:47 1 (P<0.01), but there was no difference in CRT (all P>0.05). In BRVO and CRVO patients, 12 and 8 eyes received retinal laser treatment during 3 intravitreal injections, respectively. The difference in visual acuity and CRT between the eyes treated with laser and those that were untreated was not significant (P>0.05). No ocular and systemic serious complications emerged during follow-up. CONCLUSIONS: Ranibizumab has high efficacy and safety in the treatment of macular edema secondary to RVO, visual acuity at baseline may help predict the prognosis.]]> 2022/8/29 16:22:59 2022/8/26 9:22:32 0.05). Corneal edema disappeared at 1 wk after operation. The ECD loss rate in DisCoVisc group was significantly lower than that in Healon group at 3mo after operation (P<0.05). Intraocular pressure and the proportion of patients with uncorrected visual acuity ≥ 0.5 showed no statistically significant differences between the two groups before operation, at 1d, 1wk and 1mo after operation (P>0.05). There was no significant difference in CCT value between the two groups before operation, at 1d, 1wk and 1mo after operation (P>0.05). Conclusion: DisCoVisc as the viscoelastic agent in phacoemulsification and foldable IOL implantation for patients with Emery-Little grade Ⅱ~Ⅲ lens nucleus hardness can better protect the patients’ corneal endothelium.]]> 2022/8/25 17:41:11 2022/8/25 12:17:53 2022/8/25 12:03:07 2022/8/22 10:04:15 2022/8/19 9:16:26 0.05). There was no discernible change in CT for all degrees of hyperopic amblyopia, with the exception of the nasal quadrant(P > 0.05). Conclusions: Hyperopic amblyopia is accompanied with abnormal choroidal structure. As the degree of hyperopia increases, TCA, LA, and SA exhibit increasing trends. The changes in choroidal structure are presumed to be related to hyperopic amblyopia.]]> 2022/8/15 9:34:29 2022/8/12 16:01:43 0.05). The index of success(IS) were 0.125（0.091,0.20）in the Group A,which lower than 0.200（0.167,0.250）in the Group B (p<0.05).The correction index (CI) and the flattening index (IF) were 1.0（0.922,1.079）,1.0（0.902,1.066）in the Group A.,which higher than 0.835（0.795,0.870）,0.834（0.783,0.869）in the Group(p<0.05).There are significant statistically differences between the Group A and the Group B. CONCLUSION: Topography-guided FS-LASIK and TICL were effective and safe in correcting myopia with moderate to high astigmatism,and Topography-guided FS-LASIK better accuracy than TICL for the astigmatism correction. KEYWORD: Topography-guided Femtosecond laser in situ keratomileusis；Toric implantable collamer lens；astigmatism]]> 2022/8/12 14:21:09 2022/8/11 9:36:05 2022/8/11 9:20:18 2022/8/10 10:00:05 2022/8/9 16:46:04 2022/8/9 15:45:31 2022/8/8 15:16:42 0.05); There is significant difference in AF of monocular before operation compared with 1 week, 1 month and 3 months after operation (all with P < 0.01). In high myopia group , AMP decreases significantly at 1 week and 1 month after operation (both with P < 0.01), and increases at 3 months after operation, and the increment is statistically significant (P > 0.05); There is significant difference between PRA before operation and 3 months after operation (P < 0.01); Compared with NRA before operation, the change of NRA is statistically significant at 1 week and 3 months after operation (both with P < 0.01). There is significant difference in AF of monocular before operation compared with 1 week, 1 month and 3 months after operation (all with P < 0.01). Conclusion: PRK has a good correction effect for myopia below - 9D, and the eye accommodation will be abnormal in a short time period after operation. The recovery and improvement time of accommodative function in low and moderate myopia group is shorter than that in high myopia group, but both groups can recover and improve compared with the before surgery state. It is suggested that within 1week-3 months after excimer laser surface keratectomy, it is easy to cause visual fatigue due to the change of regulation. Drugs to alleviate visual fatigue or binocular visual function training can be given in this time after PRK.]]> 2022/8/8 10:56:22 2022/8/5 14:41:28 2022/8/3 13:45:52 0.05). Conclusion: The effect of conbercept combined with laser photocoagulation for macular edema secondary to branch retinal vein occlusion is remarkable. It can effectively reduce the retinal thickness of macular fovea and improve the vision of patients and the complications are not increased]]> 2022/8/3 10:32:47 2022/8/3 9:19:23 2022/8/2 17:51:30 2022/8/2 17:00:07 2022/8/1 11:37:50 2022/8/1 11:35:56 2022/8/1 11:07:08 2022/7/29 9:41:07 2022/7/28 14:53:06 2022/7/27 17:08:21 2022/7/27 16:54:09 0.05）. The diabetes duration in proliferative DR group was significantly longer than non proliferative DR group and non DR group（P<0.05）. The diabetes duration in non proliferative DR group was significantly longer than non DR group（P<0.05）. The length of nerve fibers in age-related cataract group was significantly higher than non DR group, non proliferative DR group and proliferative DR group（P<0.05）. The length of nerve fibers in proliferative DR group was significantly less than non proliferative DR group（P<0.05）. Spearman rank correlation analysis showed that there was a negative correlation between DR stage and nerve fiber length（rs=-0.37，P=0.00）. Conclusion There was the correlation between the severity of DR and the changes of corneal SNP. The length of nerve fibers in patients with proliferative DR was significantly shorter than patients with non proliferative DR; Both proliferative DR and non proliferative Dr have loss of neural structure and it should be pay attention to the evaluation and treatment of ocular surface lesions in the treatment of T2DM fundus lesions.]]> 2022/7/27 10:16:03 2022/7/21 15:28:06 2022/7/14 9:56:01 2022/7/14 9:23:59 2022/7/13 9:46:02 0.05). The uncorrected and corrected intermediate and uncorrected near visual acuity of both groups A and B were significantly better than those of the control group, and the difference was statistically significant Significance (P<0.05). The scores of Catquest 9SF-CN scale showed that both groups A and B were more satisfied than the control group (P<0.05). The rate of lens removal of groups A and B were significantly higher than those of the control group, and group B was higher than group A with statistical significance (P<0.05). CONCLUSION: Patients with monofocal implanted on one side and SBL-3/SN6AD1 multifocal lens implanted on the opposite side can obtain better full-range visual acuity than binocular monofocal IOL, less postoperative adverse visual symptoms, and higher patient disengagement rate and satisfaction.]]> 2022/7/13 9:33:25 0.05). In the IOLMaster 700 group, the refractive error of the Barrett Universal Ⅱ formula was the smallest, and the difference was statistically significant (P<0.05). There was no statistically significant difference in postoperative refractive error between the other three formulas (P>0.05). When using the Barrett Universal Ⅱ formula to calculate the data of the two groups, the postoperative error of the A-ultrasound combined with corneal topography group was larger, and the MAE value was (0.79±0.79)D, and the difference was statistically significant (P<0.05). When using the SRK/T formula to calculate, there was no significant difference in refractive error between the two groups (P>0.05). Conclusion Compared with IOLMaster 700, the AL, ACD, and Km values measured by A-ultrasound combined with corneal topography are all lower. When using the SRK/T formula, IOLMaster 700 and A-ultrasound combined with corneal topography have high consistency for IOL power calculation. However, when using the Barrett Universal Ⅱ formula, A-ultrasound combined with corneal topography measurement will lead to hyperopia shift.]]> 2022/7/12 9:24:15 2022/7/11 10:38:12 2022/7/11 9:57:24 2022/7/11 9:55:43 2022/7/11 9:54:50 2022/7/8 9:50:25 2022/7/6 10:23:51 2022/7/4 14:58:41 59 years old, diabetes course>17 years, combined with macular degeneration, HbA1c>6.25%, vascular occlusion, and proliferative retinal traction all lead to a decrease in postoperative macular retinal blood flow density The risk factors of (P<0.05); the nomogram prediction model has better discrimination and accuracy, and has high predictive value. Conclusion Age, course of diabetes, combined macular degeneration, HbA1c, vascular occlusion, and proliferative retinal traction are all related to the decrease of retinal blood flow density in the macular area after PDR vitrectomy. Understanding the risk factors is conducive to surgical decision-making.]]> 2022/7/4 14:46:44 0.05). The results of both Pearson test and Bland-Altman analysis were highly correlated(r right eye = 0.93, r left eye = 0.94, p = 0.00). CONCLUSION: GMPE module-based modular OCT can be used for objective ocular torsion measurement with high reliability and reproducibility, and is a promising clinical alternative to the fundus color photographic method.]]> 2022/6/30 17:37:16 2022/6/30 11:26:51 2022/6/30 10:46:50 2022/6/30 9:10:12 2022/6/29 10:16:14 2022/6/28 9:51:29 2022/6/28 9:12:36 2022/6/27 10:13:20 0.05). Compared the eyes of patients with slight movement of one eye, the AE in displaced eye was greater than that in paired eye (P<0.05), while there were no differences in ACE, ARE and AVE in both eyes (P>0.05). One month after operation, the amplitude of rotation was moderately correlated with AE (r=0.564, P<0.05), and the different corneal areas, layers, and moving directions had no significant effect on ACE (P>0.05). CONCLUSION: The slight eye movement during laser scanning in SMILE has no significant influence on precision of corneal ablation. It mainly causes off-center ablation and changes of corneal astigmatism, which has little effect on the spherical equivalent and visual acuity.]]> 2022/6/16 15:36:35 2022/6/15 9:22:18 2022/6/14 9:54:39 2022/6/14 9:27:35 2022/6/14 9:09:26 2022/6/13 11:25:49 0.05);The results of confirmatory factor analysis showed that the absolute fit index of the three-factor structural model was χ2/df <2.0,and RMSEA≤0.08;The correlation coefficients of each dimension’s total score and the scale’s total score were 0.92, 0.90,and 0.83 respectively;The standard association validity analysis showed statistically significant differences between the ASS groups(P<0.01).Response analysis was statistically significant before and after treatment(P<0.01).[Conclusion]:ASS has high reliability,validity and responsiveness in the clinical evaluation of accommodative asthenopia,and is an effective tool for clinical research and screening of asthenopia in this population.]]> 2022/6/13 11:14:38 2022/6/13 10:37:15 2022/6/10 9:33:07 2022/6/9 16:00:18 2022/6/9 9:12:21 2022/6/8 9:48:04 2022/6/7 9:22:23 0.05). The refractive error of the results measured by the Barrett Universal Ⅱ formula was the smallest, followed by Holladay Ⅱ and the SRK/T formula. The Holladay Ⅰ formula had the largest error and the difference was statistically significant (P<0.05). Conclusion The AL was shortened and the postoperative ACD was deepened after phacoemulsification. A correction factor of 0.10 mm is suggested to eliminate the AL measurement error. The Barrett Universal Ⅱ formula has the best predictability in the IOL diopter calculation formula. Holladay Ⅱ and SRK/T formula are the next best formulas.]]> 2022/6/6 10:37:49 0.05),while the light band integrity of interdigitation zone (IZ) had significant difference (P=0.014, P < 0.05); The difference of logMAR BCVA between the affected eyes and the healthy eyes at the last follow-up was statistically significant (0.00 vs 0.30, P=0.002, P < 0.05). There was significant correlation between logMAR BCVA of affected eyes at the last post-operative follow-up, the involvement of macula, SVC-VD of optic disc, the integrity of light bands of ELM, MZ, EZ, OS and IZ on the outer structure of macula. Among them, logMAR BCVA were positively correlated with the involvement of macula (r=0.401, P=0.047) and negatively correlated with SVC-VD of optic disc ,the integrity of the light bands of ELM, MZ, EZ, OS and IZ on the outer structure of macula (all P<0.05). Conclusion： OCT and OCTA can be used to observe fundus changes after SB surgery for RRD to obtain long-term follow-up information related to vision prognosis,and visual prognosis depends on the recovery of retinal outer structure, and the integrity of IZ structure is more important for visual recovery;SVC-VD of optic disc is significantly correlated with visual prognosis, and whether it wascorrelated with intraocular pressure require further observation with with postoperative continuous data. Key words： rhegmatogenous retinal detachment；scleral buckling；OCT；OCTA]]> 2022/6/2 9:55:44 2022/6/1 9:15:09 2022/5/30 14:49:52 2022/5/30 10:30:13 2022/5/30 10:28:44 2022/5/27 10:47:18 2022/5/27 9:46:15 2022/5/16 10:14:01 2022/5/13 16:32:34 2022/5/13 8:55:41 2022/5/12 14:23:29 2022/5/12 13:39:13 2022/5/11 17:57:29 2022/5/11 14:14:01 2022/5/11 13:42:54 2022/5/10 15:58:07 2022/5/10 15:36:47 2022/5/9 13:59:02 2022/5/9 10:12:12 0.05).The 95% confidence intervals(CI) of Ks, Kf, Cyl and steep astigmatic axis between iTrace and IOLMaster 700 were 0.023 to 0.187 D,0.023 to 0.171 D,-0.032 to 0.095 D，-9.745 to 6.295o，and the 95% confidence of Ks, Kf,Cyl and steep astigmatic axis between iTrace and Pentacam HR were -0.289 to -0.078 D,-0.290 to 0.111 D,-0.031 to 0.101 D,-12.414 to 6.613o. The outcomes revealed non-comparable resultsin Ks and Kf between iTrace and the other two instruments, and cyl of the consistency was good.The difference of steep astigmatic axis is not clinically acceptable. There were no statistically differences between the iTrace and the other two devices among the low astigmatism (50 eyes), moderate astigmatism (34 eyes) and high astigmatism (18 eyes) groups (all P>0.05). CONCLUSION：Keratometric power and steep astigmatic axis have significant differences, and there is a poor agreement among iTrace, IOL Master 700,Pentacam HR. Although the steep astigmatic axis showed a good statistical consistency, the difference is not acceptable due to exceeding the clinically acceptable range, especially in high astigmatism group(cyl>1.5D). The measurement of corneal astigmatism before cataract surgery should be evaluated by multiple measurement methods, which is more conducive to surgical planning in all-round means.]]> 2022/5/9 9:10:19 2022/5/7 10:02:15 2022/5/6 10:31:01 2022/5/5 9:44:31 0.05). The BCVA of the two groups was no significant improvement between the baseline and the follow-up period (P>0.05). Compared with the baseline, the CFT of the conbercept group was significantly improved at 3, 6 and 12 months after treatment (Ftime=6.065, P<0.05), however, the CFT of the ranibizumab group was only significantly improved at 3 month (Ftime=6.065, P<0.05). The PED height of the two groups was significantly improved at 3, 6 and 12 months after treatment compared with the baseline (Ftime=6.686, P<0.05). The PED area and volume were not significantly improved (P>0.05). No significant differences was determined in BCVA, CFT, PED height, area and volume between the two groups during the follow-up period (P>0.05). Conclusion In this case series, conbercept and ranibizumab have good effects on type 1 MNV with fPED in nAMD, which can reduce the PED height and CFT, and stabilize the visual acuity, PED area and volume. However, conbercept can achieve longer reduction of macular edema.]]> 2022/4/29 9:25:31 0.05);There was no significant difference in spherical equivalent degree between dominant and non-dominant eyes (P > 0.05);There was no significant difference in the degree of myopia growth between dominant and non-dominant eyes (P > 0.05);There was no significant difference in the increase of myopia and the increase of myopia between the two eyes whether the right eye was dominant and the left eye was non-dominant (P > 0.05);There was a significant correlation between the degree of myopia growth in the dominant eye and in both eyes (P < 0.01). CONCLUSION:In myopic adolescents, most of the dominant eyes were right eye, and there was no difference between dominant eye and gender;Dominant eyes showed no specificity in the degree and growth of myopia,the dominant eye type do not affect the degree of myopia growth and the degree of anisometropia,but the degree of dominant myopia growth may affect the degree of anisometropia in both eyes.]]> 2022/4/29 9:13:16 0.05)；Indicators of tear film stability were significantly improved 3 months after surgery compared with those before surgery, with statistical differences (P<0.05)；6 months after surgery, corneal astigmatism was significantly lower than that before surgery, and corneal curvature was significantly higher than that before surgery, with statistical differences (P<0.05). The deviation of IOL degree ranged from -5.5D to 3.5D. Conclusion: cataract phaco can effectively improve the patients' vision, improve - stability, but still there may be a large joint operation corneal astigmatism, so after pterygium resection should be applied to lateral corneal refractive power to calculate IOL degree, treat corneal refractive state stability after cataract phaco, to ensure its prognosis.]]> 2022/4/28 16:53:19 2022/4/27 9:37:23 2022/4/27 9:30:34 2022/4/27 9:22:13 2022/4/25 9:21:06 2022/4/25 9:10:05 2022/4/12 9:54:43 0.05) and discrimination (area under the curve was 0.877, 95%CI: 0.830-0.924, sensitivity was 84.29%, specificity was 88.94%). The predictive scoring model was further constructed，and the critical value of NVG after CRVO was 5 points, the area under the curve was 0.844 (95%CI: 0.790-0.898), the sensitivity was 78.57%, and the specificity was 87.44%. Conclusion Ischemic CRVO, IOP≥18mmHg at the first visit, hypertension, RAPD≥0.75 logU at the first visit, UC-VA＜0.30, and anti-VEGF therapy are closely related to NVG after CRVO, and the predictive model established on this basis has good predictive efficacy.]]> 2022/4/11 11:06:19 2022/4/11 10:36:01 2022/4/8 16:10:04 2022/4/8 16:04:06 2022/4/8 14:55:21 2022/4/8 11:13:12 2022/4/7 9:27:56 0.01) by 28 day after surgery. The results of histopathological examination showed that by 28 d after corneal transplantation, there were 4~5 layers of corneal epithelial cells covering the surface of the implant in the experimental eyes, the corneal collagen was neatly and regularly arranged, no obvious inflammatory cell infiltration was seen in the implant, the boundary between the two lenses disappeared, the interlayer FS was completely absorbed by the organism, the implant was fused with the implant bed, and no obvious demarcation was seen. CONCLUSION: The use of FS pasted double-layer corneal stroma lens as a graft for lamellar keratoplasty has better recovery, less rejection and better biocompatibility, and can be used for lamellar keratoplasty.]]> 2022/4/6 13:51:51 2022/4/6 11:06:02 2022/4/6 10:52:04 2022/4/2 16:02:29 2022/4/2 10:21:58 0.05), and no significant difference in retinal detachment, vitreous hemorrhage and intraocular lens deviation after operation (P>0.05). •CONCLUSION:Posterior capsulotomy is safe and reliable in the application of silicone oil removal combined with cataract surgery for diabetic retinopathy,,and can effectively avoid the occurrence of posterior capsular opacification.]]> 2022/4/2 10:05:13 0.05); compared with the external membrane defect group, the LogMAR in the external membrane intact group was lower The levels of BCVA, CRT and MI were lower (P > 0.05), but there was no significant difference in CRV, at, P1, P2, bcea63 and bcea95 between the two groups (P > 0.05), and there was no significant difference in the presence of hard exudation (P > 0.05). There was a significant negative correlation between retinal thickness and sensitivity in temporal, central and nasal sides of fovea (P < 0.05), but no significant correlation in the upper and lower parts of fovea (P > 0.05). In the intact is / OS group, the sensitivity of retina was negatively correlated with the thickness of retina and BCVA, while the thickness of retina was positively correlated with BCVA (P < 0.05).Conclusion: The visual function of patients with diabetic macular edema is closely related to the morphology and structure of macular area, especially the integrity of is / OS layer and outer membrane. MI is an important index to evaluate the visual function of patients with diabetic macular edema.]]> 2022/4/1 13:44:43 0.05); ELISA results revealed that the expression levels of RBPJ, IFN-γ and IL-17 proteins in all tissues from EAU rats on day 12 d after immunization were significantly higher than those in the NC group ( all P < 0.05), and there was no statistically significant difference in the expression levels of Rbpj, IFN-γ and IL-17 protein in all tissues of rats in the blank control group compared with the NC group (all P>0.05); meanwhile, flow cytometry results showed that the proportions of Th1 and Th17 cell lineages in all tissues from EAU model group were significantly higher than those from the NC group on day 12 after immunization, and the differences were statistically significant (all P<0.05),furthermore ,there was no significant change in the proportion of Th1 and Th17 cells in each tissue in the blank control and NC groups (all P>0.05). Conclusion miR-223-3p can negatively regulate the expression of the transcription factor Rbpj of Notch signaling pathway. The down-regulated miR-223-3p expression in EAU rats can increase the expression levels of Rbpj gene and protein, and aggravate the differentiation of Th1 and Th17 cells and the expression levels of related molecules IFN-γ and IL-17, which in turn affect the development of uveitis. Keywords miR-223-3p; Rbpj; Experimental autoimmune uveitis; Th1; Th17; IFN-γ; IL-4]]> 2022/3/31 11:06:14 2022/3/29 16:30:05 2022/3/29 10:16:56 2022/3/29 9:44:16 2022/3/29 9:33:23 2022/3/29 9:32:46 2022/3/29 9:25:50 2022/3/28 10:38:51 2022/3/25 9:45:42 0.05). Corneal astigmatism of the two groups was significantly reduced at 1 mo and 3 mo after surgery. The observation group had significantly lower corneal astigmatism than the control group at 3mo after surgery (P<0.05). SAI and SRI were reduced in the two groups at 1mo and 3mo after surgery. Meanwhile, SAI and SRI in the observation group were significantly lower than those in the control group (P<0.05). The corneal epithelial healing rates in observation group at 1 wk and 1mo after surgery were significantly higher than those in the control group, but there was no statistically significant difference in corneal epithelial healing rate between the two groups at 3 mo after surgery (P>0.05). No grade 4 pterygium recurrence was observed in the two groups within 12 months after surgery. The situation of pterygium recurrence was similar in the two groups at 6 mo and 12 mo after surgery (P>0.05). There was no statistically significant difference in the incidence of complications between the two groups (P>0.05). CONCLUSION: Both pterygium resection combined with Ologen collagen matrix implantation and pterygium resection combined with autologous conjunctival flap transplantation are effective in the treatment of pterygium, with equivalent safety. However, the former has more advantage in improving corneal astigmatism, which is more conducive to shape restoration of corneal wound.]]> 2022/3/16 9:30:23 31.26 ng/mL, IL-6>29.42 ng/mL, TNF-α>77.68 ng/mL, HbA1c<6.50% are all independent risk factors leading to postoperative dry eye syndrome (P<0.05); The calibration curve and the standard curve of the nomogram prediction model have a good fit, and the prediction probabilities are mostly distributed around 0 and 1, with high accuracy; visual function evaluation, environmental triggers, and ocular discomfort symptoms of patients in the dry eye group The OSDI score was significantly higher than that of the normal group (P＜0.05). Conclusion Surgical incision, postoperative anxiety, depression, medication compliance, serum inflammatory factor levels and HbA1c are all related to dry eye after cataract surgery in type 2 diabetic patients. Early identification of risk factors and timely intervention can help reduce postoperative dry eye The incidence of disease and improve the quality of life.]]> 2022/3/15 16:39:59 0.05).The changes in BCVA,IOP,and FAZ within the A and B group were statistically significant(P<0.01) when compared with those within the A and B group.The changes in perfusion area of RPCP,SVP,IVP, and DVP within each A and B group were statistically significant(P<0.01),and the perfusion area of each layer gradually increased after surgery;The perfusion area on the intrinsic CCL and choroidal layers and the thickness change of the choroidal layer in the AB group were not statistically different(P>0.05);The blood flow density changes of SVP,IVP,and DVP within each group in A and B group were all statistically significant(P<0.05) and showed a significantly increasing trend after surgery. ·CONCLUSION:The retinal thickness,blood flow density and perfusion area in all layers of the retina increased and the FAZ area decreased in the macula after cataract surgery,which may help to promote the recovery of visual acuity after surgery.Under different intraocular pressures of 55.5mmHg and 66.6mmHg during cataract surgery,there was no significant difference in the postoperative fundus blood flow changes between the two groups,intraoperative intraocular pressure can be flexibly selected to provide patients with personalized surgical design. ·KEYWORDS: cataract;SS-OCTA;intraocular pressure;macular;blood flow]]> 2022/3/14 9:33:35 2022/3/11 10:23:24 2022/3/10 16:14:35 0.05). The number of eyes with visual improvement was significantly raised 6 months after treatment in study group (X2=8.127，P=0.011). There were no significant differences in BCVA between two groups 6 months after treatment（X2=0.122，P=0.989）. The IOP of study group at 1week、1、3 and 6 months was significantly lower than that before operation (all at P<0.001). There were no significant differences in IOP between the two groups (Fgroup =0.003, P=0.956). The anterior chamber significantly deepened at 1 and 6 months after operation in two groups respectively (all at P < 0.001). There were no significant differences in ACD and central corneal endothelial cells count between two groups (all at P>0.05). The duration of operation was (26.1?4.5)min in study group and (31.5?5.1)min in control group, which showed significant differences （t=-3.307，P=0.002）. The length of stays after surgery was (7.2?1.6) d in study group and (7.7?1.5) d in control group, and there was no significant difference between the two groups (t=-0.880, P=0.388). One Express touched the iris in study group. Since the IOP was normal, it didn’t receive therapy. In control group, the anterior chamber of 2 eyes was 2 degrees shallow after surgery, which recovered in a week by pupil dilation and pressurized bandage. At 6-month point after operation, one eye in each group was treated with one IOP drop to maintain normal IOP. In control group, one case received Express drainage device implantation again 12 months later for recurrent glaucoma, another case underwent ciliary body photocoagulation 8 months later. CONCLUSION: EX-PRESS drainage device combined with phacoemulsification and trabeculectomy combined with phacoemulsification are both effective in improving visual acuity and controlling IOP for CPACG, but the former takes shorten operation time.]]> 2022/3/10 14:43:11 2022/3/10 9:32:37 T (p.P241L), c.1186 C>T (p.R396X) in the OAT gene of the proband in exons 6 and 10, respectively, and this compound heterozygous mutation showed co-segregation in the family. The heterozygous p.R396X pathogenic variant was detected in both the proband's father and elder brother, and the heterozygous p.P241L pathogenic variant was detected in her mother. Except for the proband, the other family members had no clinical symptoms. Conclusions The proband of this family was a compound heterozygous mutation, of which p.P241L was the first reported gene mutation. The results of this study expand the spectrum of genetic variants in OAT and are beneficial for further understanding of the pathogenetic factors of GA on its molecular basis. The discovery and confirmation of novel mutation types will also help to provide a new basis for the clinical diagnosis and gene therapy of gyrate atrophy of choroid and retina.]]> 2022/3/9 10:26:14 0.05; CA: t = 1.80, p > 0.05; TA: t = 1.50, p > 0.05; SA: t = 1.97, p > 0.05).The scores of SR, MTF cutoff in MGD and ADDE group were significantly lower than those in control group, and the value of OSI was significantly higher than that in control group (all P < 0.001).There was no statistically significant differences between MGD group and ADDE group with the value of MTF cut off, SR and OSI [MTF cut off: (33.28± 8.28 ) vs (37.12 ± 9.53 ), SR: ( 0.19± 0.06 ) vs ( 0.22 ± 0.08 ), OSI: ( 1.30 ± 0.32 ) vs (1.12 ± 0.52 )] (MTF cut off: t =1.52, p > 0.05; SR: t = 1.50, p > 0.05; OSI: t = 1.47, p >0.05 ). In the condition of not blinking, the mean value of OSI in MGD group was significantly higher than that in ADDE group [( 2.386 ± 0.118 ) vs ( 1.554 ± 0.058 )] ( p < 0.001). Conclusions: In treatment of symptoms of patients with dry eye, improving the visual quality of patients should also be considered. The visual quality in patients with MGD is more serious than those with ADDE. The OSI related parameters seem to be sensitive indicators indexes to evaluate the dynamic changes of tear film-related visual quality in dry eye patients. Key words: Dry Eye Syndromes; visual acuity; Meibomian Glands; tears]]> 2022/3/9 9:04:52 0.01)；There was no significant difference in RPE between group B and 0 (P > 0.05). The ratio of Barrett Ⅱ formula in RPE 0.50D in group A was significantly higher than SRK / T, Hoffer Q, Holladay 2 and Haigis formula (P < 0.01), and there was no significant difference compared with Kane formula (P > 0.01); In group B, there was no significant difference between Barrett Ⅱ formula and the other formulas in the ratio of RPE 0.50D and 1.0D(P > 0.01); In group C, the ratio of SRK / T and Hoff Q formula in RPE 0.50D was lower than Barrett formula (P < 0.01), and there was no significant difference between Barrett Ⅱ formula and the other formulas in the ratio of RPE 1.0D (P > 0.01). CONCLUSION: If k＜42D or k＞46D, the commonly used formulas will produce refractive error, but the accuracy of Kane and Barrett Ⅱ formulas is still higher than other formulas.]]> 2022/3/9 8:54:10 2022/3/7 13:50:11 2022/3/7 10:40:33 0.05), but the incidence of CME, ellipsoid band interruption and NSD were significantly higher than those before operation (P <0.05). Conclusion: We suggest that phacoemulsification did not significantly accelerate ERM progression and affect BCVA,But patients undergoing cataract surgery in the presence of epiretinal membranes need tight follow up to treat and control eventual macular infammatory changes and eventual prompt vitrectomy if BCVA is threatened.]]> 2022/3/7 10:34:13 2022/3/4 10:03:03 2022/3/2 11:32:36 0.05). The AI values of two-point localization sensation, tactile sensation, and pain sensation in both groups were higher at 1 week after surgery than before surgery (all P < 0.05), and the symptoms of sensory impairment were aggravated, with different degrees of improvement at 1 month after surgery and statistically significant differences in pain sensation at 3 months after surgery (P < 0.05), and two-point localization sensation, tactile sensation, and pain sensation were significantly improved at 6 months after surgery than before treatment (all P < 0.01). At 1 month after surgery, the differences in two-point localization sensation and pain sensation in the test group were statistically significant compared with the control group (t=-2.082, -2.143; p=0.044, 0.038). At 3 months after surgery, there was a statistically significant difference in nociception in the test group compared to the control group (t=-2.118, p=0.04). At 6 months after surgery, there was no statistically significant difference in quantitative sensory testing between the two groups. Conclusion: Local application of trimethoprim combined with mouse nerve growth factor for the treatment of infraorbital nerve injury after infraorbital wall fracture was effective in early internal recovery and superior to the group without special intraoperative treatment.]]> 2022/3/2 10:39:10 2022/3/2 10:04:40 2022/3/1 14:41:31 0.05)；The surgical efficiency of patients with DIP endoscopic score <16.5 was better than that of patients with DIP endoscopic score ≥ 16.5 (P <0.05).Conclusion: DIP endoscopic scoring system has a good predictive value for the prognosis of endoscopic of transnasal endoscopic sinus opening combined with dacryocystorhinostomy.]]> 2022/3/1 9:37:48 2022/2/28 11:09:49 2022/2/28 10:44:37 2022/2/25 9:29:19 2022/2/9 14:04:52 2022/2/9 9:13:30 0.05). Conclusion:The incidence of PCO in diabetic patients after cataract surgery was higher than that in non-diabetic patients, and the degree of opacity was more severe. Preoperative course of diabetes and the presence of DR were risk factors for PCO. Key words: posterior capsular opacification; diabetic; cataract； Phaco+IOL；HbA1c]]> 2022/2/8 9:35:56 0.05). The rate of complete success observed three months after operation was superior in PPF group (92% vs 53%，P<0.05). PACD was found to be deeper 1wk after the operation in PPF group as compared with the values before the operation and was deeper than that in TRA group (P＜0.05); while this comparison in TRA group showed no significant change (P>0.05). After the operation, the anterior chamber angle was open and the anterior chamber was deepened in PPF group. No significant changes in visual acuity before and after the operation within each group and between groups were observed 3 months after the surgery (P>0.05). The incidence of postoperative hemorrhage in anterior chamber was lower in PPF group (8% vs 47%，P<0.05); no significant between-group difference was found in other complications such as choroidal detachment and low postoperative IOP (P>0.05). CONCLUSION Both PPF and TRA surgery can successfully control IOP of NVG. However, PPF surgery appeared to be superior as having a higher complete success rate. In addition, PPF surgery makes the anterior chamber deeper and wider, and result in fewer severe postoperative complications. KEYWORDS：neovascular glaucoma; pars plane; filtration surgery; trabeculectomy; intraocular pressure; anterior chamber depth]]> 2022/2/7 11:36:31 0.05). After 6 month of surgery, UDVA were significantly better than pre-operation in two groups, average visual acuity of LogMAR was above 0.1. There were no significant differences in UDVA、BCVA、UIVA and UNVA between two groups. The Patients' far, intermediate, and near distances satisfacation were higher after 3 month of surgery. There were no statistically significant differences in spatial frequency contrast sensitivity between the two groups under photopic/mesopic conditions and mesopic with glare 6 months after surgery. The scores of satisfacations for reading fluency were better in the bilateral group than in the unilateral group(P<0.05). After 6 months, the reading speed of binocular group was slightly higher than the unilateral group, but there was no significant difference between the groups (P>0.05). Conclusions The Tecnis Symfony extended depth of focus IOL provides good far, intermediate, and near visual acuity in the bilateral group and the unilateral group, while maintaining the same level of visual quality. In both groups over 90% patients were spectacle independent. Symfony IOL has widely adaptability and highly predictable, patients can obtain better satisfacations for reading fluency and reading speed. It is more suitable for intermediate vision.]]> 2022/1/29 11:11:41 0.05). Statistically significant differences were all found in pupil diameter increase and accommodative amplitude decrease between two groups (all P < 0.05). Six children (10.3%) were mild photophobic in the early stage in the 0.005% atropine group. Photophobia disappeared in 4 and 2 children after using 0.005% eye drops 2 weeks and 4 weeks, respectively. No children showed any other discomfort symptoms such as blurred vision or allergy in the two groups. •CONCLUSION: Compared to wear SV spectacles alone, regular application of 0.005% atropine could somewhat control the progression of myopia in children with low myopia in Central Planes of mainland China. However, its clinical effect was not obvious.]]> 2022/1/29 11:11:18 2022/1/28 16:09:10 2022/1/25 9:21:56 2022/1/24 10:38:05 2022/1/24 9:19:15 2022/1/23 22:22:22 2022/1/23 22:08:15 2022/1/21 9:10:43 2022/1/20 10:05:52 2022/1/20 9:03:33 2022/1/19 9:48:14 2022/1/19 9:32:56 2022/1/5 9:47:09 2022/1/4 17:34:33 2022/1/4 17:11:28 2021/12/30 14:24:57 0.05). With the extension of treatment time, the foveal retinal thickness and the nasal retinal thickness of the inner ring in the central fixation group and the paracentral fixation group became thinner（p<0.05）.At the same measurement time, the thickness of fovea and inner ring nasal retina in the central fixation group was thinner than that in the paracentral fixation group, the difference was statistically significant (p<0.05), and there were no significant differences in the thickness of other retinas in the macular region（p>0.05）.There were significant differences in ocular axis, BCVA and equivalent spherical power of amblyopia before and after treatment (p<0.05); With the extension of treatment time, the length of ocular axis and BCVA had increased and the degree of equivalent spherical mirror had decreased. The macular retinal thickness of Hyperopia Amblyopia was thicker than that of contralateral normal eyes, and the length of ocular axis was shorter than that of contralateral normal eyes (P<0.05). The axial length of amblyopia and normal eyes had changed significantly before and after treatment (p< 0.05). The axial length of amblyopia was shorter than that of normal eyes. With the extension of treatment time, the axial length of amblyopia and normal eyes had become longer. Conclusions：The thickness of macular retina in moderate and high amblyopic eyes was thicker than that in contralateral normal eyes, and the ocular axis was shorter than that in contralateral normal eyes. After treatment, with the improvement of best corrected visual acuity, the retinal thickness of fovea and nasal side of inner ring in central fixation group and paracentral fixation group had decreased. Keywords：amblyopia;fixation nature; retinal thickness in macular; axis oculi;optical coherence tomography.]]> 2021/12/29 14:41:46 2021/12/28 11:25:44 2021/12/26 18:05:40 2021/12/24 8:22:54 2021/12/24 8:16:27 2021/12/23 20:21:43 0.05). At 6mo after treatment, BCVA in observation group was higher than that in control group, while CMT was lower than that in control group (P<0.05). There was no significant difference in CMT between the two groups at the other time points (P>0.05). The mean injection times in observation group were more than those in control group [(5.81?0.54) times vs (4.19?0.41) times] (P<0.05). In the early stage of postoperative follow-up, there were 30 times (22.73%) and 15 times (21.74%) of subconjunctival hemorrhage in observation group and control group, respectively (P>0.05). There were no other severe complications in either group. Conclusion: The curative effect of both conbercept 3 combined with PRN and conbercept 5 combined with PRN is good on patients with diabetes and CSME, which can significantly improve visual acuity and reduce CMT. Their improvement effects are comparable. The conbercept 5 combined with PRN regimen may increase injection times with tolerable adverse reactions, which is safe and reliable.]]> 2021/12/9 15:49:55 2021/12/2 15:37:47 0.05).The Intraocular pressure in postoperative 1 week,1 month,3 month and 6 month were reduced than preoperative,there were not significantly different between each postoperative period(P>0.05).The ACD in postoperative 1 week,1 month,3 month and 6 month were deepen than preoperative,there were not significantly different between each postoperative period(P>0.05).The TIA in postoperative 1 week,1 month,3 month and 6 month were widened than preoperative,there were not significantly different between each postoperative period(P>0.05).The AOD500 in postoperative 1 week,1 month,3 month and 6 month were increased than preoperative,there were not significantly different between each postoperative period(P>0.05).The depth of anterior chamber angle in four quadrants were deepened combined with the depth in postoperative 1 week,1 month,3 month and 6 month.（P<0.05）. CONCLUSION:Phacoemulsification Intraocular lens implantation and Goniosynechialysis in the Treatment of Acute Angle-closure Glaucoma with Cataract can significantly improve visual acuity,increase the depth of central anterior chamber,open angle,reduce intraocular pressure. It is an effective and stable surgical method.]]> 2021/12/2 9:14:18 2021/12/1 14:11:57 2021/12/1 14:04:06 2021/11/29 10:43:43 2021/11/26 9:34:34 2021/11/26 9:08:45 2021/11/24 11:44:24 0.05). There was no significant difference in central corneal thickness 2 weeks after operation compared with that before operation (P > 0.05). There were 3 cases of low intraocular pressure and 2 cases of high intraocular pressure, but they all returned to normal at the end of follow-up.The intraocular lens were all centered and there were no obvious eccentricity and inclination. No other complications such as vitreous hemorrhage and retinal detachment occurred.Conclusion: 25G vitrectomy, phacoemulsification combined with intrascleral fixated intraocular lens implantation is a fast, safe and simple method for the treatment of complete lens luxation.]]> 2021/11/24 9:14:39 2021/11/23 9:29:46 0.05). CONCLUSIONXueshuantong iontophoresis combined with intravitreal injection of Conbercept for RVO with ME can effectively inhibit the expression of VEGF, reduce macular edema and improve the visual acuity of the affected eyes. The efficacy and safety are worthy of recognition.]]> 2021/11/8 16:03:32 0.05). 1mo after surgery, the corneal fluorescein staining (FL) value of group C was significantly lower than that of group A and that of group B (P<0.05). Corneas of the three groups were transparent or with mild pannus, but no angiogenesis was found. No recurrent true pterygium was observed in the three groups. 6mo and 12mo after surgery, the grades of conjunctival fibroplasia in group A and group C were significantly different from that in group B (P<0.05). There were no statistically significant differences in the wet length of the filter paper in Schirmerl test in terms of time, inter-group and interaction effects (P>0.05). 1mo after surgery, the tear film breakup time (BUT) of group C was significantly longer than that of group A and that of group B (P<0.05). There were different degrees of conjunctival edema in the three groups after surgery, which disappeared within 2 wk after suture removal. Grafts of the three groups all survived, vascularization of amniotic membrane grafts ended, which were transparent and fused with its own bulbar conjunctiva. CONCLUSION: All of CAT, AMT and CAT combined with AMT can achieve satisfactory results in the treatment of pterygium. The short-term corneal epithelial repair effect after CAT combined with AMT is relatively better, and conjunctival fibroplasia and dry eye symptoms are milder.]]> 2021/11/8 14:13:57 0.05). Furthermore, IOP in both groups remained in normal level during the follow-up period, 0.5% and 2.3% reduction of CECD in A group and B gruop was observed at 1 year after operation respectively (P<0.05). Both IOP and CECD between the two groups have no significant differenc at each time point during the follow-up period(P>0.05).There was no significant difference between whole eye astigmatism and corneal astigmatism in A group and B gruop at 1 month and 6 months after operation (P>0.05). Additionally, There was 1 case of IOL dislocation in each group after operation, which was further recovered by operation. Significant tilt and deviation of IOL were not observed in the rest of the patients during the follow-up period. The other postoperative complications were mild with no difference in complications between the two groups.(P>0.05). CONCLUSION: For aphakic eyes without capsular support, both retropupillary iris claw IOL implantation and posterior chamber ciliary scleral suture fixed IOL are safe and effective surgical methods. Retropupillary iris claw IOL implantation has relatively simple operation, lower damage to the eyeball tissue, the shorter operation time, and the quicker recovery of postoperative visual acuity, which is one of the effective clinical treatments.]]> 2021/11/8 10:27:21 2021/11/8 10:15:17 2021/11/4 9:10:32 0.05); The proportion of diabetes, high myopia, preoperative uveitis, preoperative ocular trauma and intraoperative complications in high intraocular pressure group was higher than that of non-high intraocular pressure group, with the difference was statistically significant (P<0.05). Cox regression analysis showed that diabetes, high myopia, preoperative uveitis, preoperative ocular trauma and intraoperative complications were independent risk factors for high intraocular pressure after cataract surgery in PLG patients. The nomogram model constructed in this study had good fitting effect, and the area under the ROC curve was 0.906(0.890-0.921), indicating that it had strong predictive ability. Conclusions PLG patients with intraoperative complications, preoperative uveitis, ocular trauma, diabetes and high myopia had higher risk of high intraocular pressure after cataract surgery. Clinical doctors should pay more attention to these patients in order to improve the treatment prognosis.]]> 2021/11/3 10:34:12 2021/11/3 9:59:16 0.05). The BCVA improved significantly at postoperative compared with BCVA at baseline in both gorups (Group A: F=19.419 P<0.001; Group B: F=38.040 P<0.001). The BCVA was better in group A than group B at 6 months postoperatively (Z=-2.026 P=0.043). No statistically significant difference was found in BCVA between the two groups at 12 months, 24 months and 36 months after initial treatment (Z=-0.349 P=0.727, Z=-1.067 P=0.286, Z=-0.139 P=0.889). No statistically significant difference was found in axial lengths between 6 months of postoperation and preoperation in both groups (Group A: t=1.387 P=0.206 Group B: t=1.685 P=0.082). The mean postpoerative axial lengths at 12 months, 24 months and 36 months were longer than that at baseline in both group (Group A: t=2.620 P=0.023, t=2.855 P=0.015, t=5.437 P<0.01 Group B: t=3.379 P=0.018, t=4.963 P<0.01, t=7.531 P<0.01). There were no significantly different in mean axial length after operation between the two groups (6 months: t=-1.467 P=0.195, 12 months: t=-1.081 P=0.313, 24 months: t=-0.877 P=0.485, 36 months: t=-1.574 P=0.089). The IOP>21mmHg was recorded in 2 and 6 eyes in group A and group B respectively. That was transient and successfully treated with topical medications. The posterior synechia of the iris was observed in 3 eyes in group B. Conclusions 25-gauge sutureless lensectomy combined with capsulotomy and anterior vitrectomy is an effective and safe treatment method for congenital cataract, the visual acuity after treatment was improved significantly.]]> 2021/10/29 9:28:35 0.05). Conclusion: Contrast-enhanced ultrasound can provide imaging basis for the differential diagnosis of orbital retrobulbar tumors which is helpful for the preoperative qualitative diagnosis.]]> 2021/10/28 9:58:02 2021/10/27 9:47:20 2021/10/27 9:38:42 2021/10/11 14:30:00 2021/10/9 16:35:22 12 years, IGF-I > 145 μg/L, Cmurl P < 0.75 ng/mL, UA > 245 ng/mL, RBP4 > 54 mg/L, NLR > 1.8 and PLR > 110 were independent risk factors for DR.?The line chart model has high degree of differentiation and calibration, and has good prediction efficiency. Conclusion In addition to the common risk factors such as the course of DM, IGF-I, Cmurp and UA, the increase of RBP4, NLR and PLR is also related to DR, which may be involved in the occurrence and development of DR.]]> 2021/10/8 9:56:18 0.05). After treatment, there were statistically significant differences in BCVA between group A and group B at 2 weeks and 1 month. There were statistically significant differences between group A1 and group A2 at 1 month, 6 month and 12 month (P=0.019, 0.042, <0.001), also significant differences had shown between group B1 and group B2 at 1 month (P=0.033). The effect of the laser treatment was significantly different between the two groups, group A was better than group B (P=0.006), group A1 was significantly better than that in group A2, and the difference was statistically significant (P<0.001).Compared to traditional Nd: YAG laser, ultra Q: YAG laser requires less frequency of laser treatment (P<0.001), and had no significant relationship with vitreous opacity (P>0.05). Conclusions：Ultra Q: YAG is easier to operate, safer and has better subjective symptom improvement than traditional Nd: YAG laser treatment of vitreous floaters, especially for the patients with Weiss ring, floccule and dense membrane.]]> 2021/9/30 12:54:10 2021/9/28 10:00:10 2021/9/27 17:13:41 2021/9/27 9:09:42 2021/9/26 10:40:35 2021/9/23 9:32:38 2021/9/22 10:05:26 2021/9/18 9:07:13 2021/9/17 17:08:52 0.05). The uncorrected visual acuity and best corrected visual acuity of patients with different energy parameters at 1 month after operation were significantly higher than those before operation (P<0.05). There was a statistically significant difference in the naked eye and best corrected visual acuity of patients with different energy parameters at 1 month after surgery (P<0.05). The naked eye and best corrected visual acuity showed a decreasing trend with the increase of energy parameters (P <0.05). The MTFcut-off and OSI of patients with different energy parameters at 1 month after operation were significantly higher than those before operation (P<0.05). The differences in MTFcut-off and OSI of patients with different energy parameters at 1 month after operation were statistically significant (P<0.05). MTFcut-off and OSI showed a decreasing trend with the increase of energy parameters (P<0.05). Energy parameters in SMILE were significantly negatively correlated with naked vision, best corrected vision, MTFcut-off, and OSI (P<0.05). CONCLUSION 130 nJ is the energy parameter that best matches the 4.5 μm dot pitch, and the OBL used for SMILE surgery is lower, postoperative vision recovery and visual quality are higher.]]> 2021/9/3 16:40:00 2021/9/3 16:26:55 2021/9/3 10:00:35 0.05). The mean axial difference △AL were -0.28±0.2 and 0.05±0.31mm between the two groups with independent sample t test (p<0.05), while △K, MARE and △astigmatism (p>0.05). The preoperative and postoperative AL in high myopia groups were 28.37±1.73 and 28.10±1.55mm (t=3.994, p<0.05), yet the non-high myopia group (p>0.05). Bivariate linear correlation analysis: In the high myopia group, there was a moderate positive correlation between preoperative AL and MARE (r=0.742, p<0.05), and a moderate negative correlation between △AL and MARE (r=-0.646, p<0.05), but in non-high myopia group, preoperative AL, △AL, preoperative K, △K (p>0.05). Conclusions: IOL-Master performed the small biostatistical error and high measurement accuracy of the intraocular lens in patients with silicone oil filled eye complicated cataract. The longer preoperative AL, the more changes in the axial length after silicone oil removal, and the greater the refractive error of patients with high myopia silicone oil filled eye complicated cataract.]]> 2021/9/1 9:48:17 2021/8/30 10:17:31 2021/8/27 10:13:12 2021/8/27 9:28:59 2021/8/24 9:43:50 2021/8/24 9:20:24 2021/8/20 10:13:57 2021/8/20 9:51:46 2021/8/17 17:13:27 2021/8/11 16:39:40 2021/8/11 16:37:30 2021/8/8 17:32:29 0.05). CONCLUSION: The development of bony nasolacrimal duct in the affected side of congenital nasolacrimal duct obstruction is different from that in the healthy side. The initial segment of the affected side expanded obviously.]]> 2021/8/8 17:31:39 2021/8/4 14:21:08 2021/8/2 14:22:36 2021/7/30 17:15:36 2021/7/30 14:09:02 0.05). The intraocular pressure of the two groups decreased significantly (P<0.05), without statistical difference between groups (P>0.05). After surgery, the coefficient of variation of cell area, proportion of hexagonal cells, average cellular area, and central corneal thickness of group A were lower and smaller than those of group B, while corneal endothelial cell density was higher than group B (P<0.05). After surgery, OCT parameters such as anterior chamber depth (ACD), angular opening distance 500 (AOD500), trabecular iris angle (TIA), and angular recess area (ARA) increased in the 2 groups (P<0.5), without statistically significant differences between groups (P>0.05). The incidence of ocular hypertension requiring drug control and the total incidence of ocular hypertension were significantly lower in group A than in group B (P<0.05). Conclusion: Compared with TRAB Phaco IOL, ECP Phaco IOL can achieve a higher complete success rate in the treatment of glaucoma with cataract, with less influence on corneal cells.]]> 2021/7/30 14:02:20 0.05); After treatment, the clinical symptom score, OSDI, FL, TNF-α, IL-6, MDA, LPO were significantly reduced, and BUT, SIt, SOD, TAC were significantly increased, and the clinical symptom score and ocular surface function of the observation group after treatment The improvement of inflammatory factors and oxidative stress indicators was significantly better than that of the control group (P<0.05). Conclusion Preoperative intervention with rbFGF combined with artificial tears can significantly improve the postoperative ocular surface function of patients with cataracts and dry eye, reduce the level of inflammatory factors in tears, and improve the symptoms of dry eye, which provides a reference for the clinical treatment of cataracts and dry eye.]]> 2021/7/30 10:59:17 1mo after surgery> 3mo after surgery = 6mo after surgery (P<0.05). Comparison of total high-order aberration RMS before and after surgery in the two groups showed that before surgery<1mo after surgery<3mo after surgery=6mo after surgery (P<0.05). The postoperative BCVA and total high-order aberration RMS in combined group were lower than those in control group (P<0.05). There was no significant difference in the corneal endothelial cell density between the two groups (P>0.05). Comparison of postoperative anterior capsular orifice area in the two groups showed that 1mo after surgery> 3mo after surgery> 6mo after surgery (P<0.05), and the area in combined group was higher than that in control group at 3mo and 6mo after surgery (P<0.05). Comparison of postoperative IOL inclination angle within the groups showed that 1mo after surgery<3mo after surgery<6mo after surgery (P<0.05), and the angle in combined group was lower than that in control group at 3mo and 6mo after surgery (P<0.05). The total incidence rate of postoperative complications in combined group was lower than that in control group (P<0.05). Conclusion Phacoemulsification IOL implantation CTR implantation can improve the visual function of patients with high myopia complicated with cataract, with few postoperative complications and good efficacy and safety.]]> 2021/7/29 12:22:25 2021/7/29 9:36:00 0.05), and there was significant difference in the diameter of retinal vein and diameter of perimacular capillary between different stages of NPDR (p<0.05). The multiple comparison of retinal vein diameter and perimacular capillary diameter in different groups was statistically significant (p<0.01). the average score of retinal vein diameter in the range of 0-0.5PD was "stage Ⅲ course > stage Ⅱ course > stage I course > normal group > control group ", The average score of retinal vein diameter group in the range of 0.5-1.0PD was "stage Ⅲ course > stage Ⅱ course > stage I course ) > normal group > control group ", the average score of perimacular capillary diameter group was "stage Ⅲ course > stage I course ) > control group ; Stage Ⅲ course ) > normal group ; Stage Ⅱ course > stage I course > control group ; Stage Ⅱ course > normal group ; The diseased normal group > the control group ",while there was no significant difference between the stage Ⅲ course and the stage Ⅱ course, the stage I course and the diseased normal group (p>0.05). Conclusion ：Retinal artery diameter has no obvious change in NPDR stages. The retinal vein and perimacular capillary in diabetic patients are dilated. In different stages of NPDR, the diameter of the vein and perimacular capillary is gradually widened.]]> 2021/7/29 9:29:50 2021/7/28 16:21:51 2021/7/28 9:39:18 2021/7/27 9:19:31 2021/7/26 9:45:02 2021/7/23 10:04:06 2021/7/23 9:08:24 2021/7/22 15:39:48 2021/7/22 9:21:19 0.05), but the observation group received fewer vitreous injections than the control group (P<0.05). The best corrected visual acuity (BCVA) of the two groups after treatment was higher than that before treatment, while the central macular thickness (CMT) decreased significantly, compared with that before treatment (P<0.01). The BCVA 1mo after treatment and CMT 3mo after treatment of the observation group were higher than those of the control group (P<0.01), but there was no significant difference in two two indexes between the two groups at 6mo after treatment (P>0.05). After treatment, the intraocular pressure of the two groups increased, and the observation group had higher intraocular pressure than the control group 1wk, 1mo, 3mo, and 6mo after treatment (P<0.05). The blood flow density of superficial capillary plexus (SCP) in the two groups after treatment was significantly higher than that before treatment (P<0.05), without statistically significant differences between the groups (P>0.05). No significant changes in blood flow density of deep capillary plexus (DCP) and the area of foveal avascular zone (FAZ) were observed, showing no significant differences within and between the groups (P>0.05). The incidence of increased intraocular pressure was higher in the observation group than in the control group (P<0.05). CONCLUSION: TA combined with macular grid photocoagulation for treating ME secondary to BRVO can maintain the vision at a certain level in the short term. The combined treatment can achieve visual acuity and CMT equivalent to the combination of conbercept and macular grid photocoagulation. However, the intraocular pressure may increase, which requires strengthened intraocular pressure monitoring.]]> 2021/7/8 9:25:58 0.05). ②At 6months after surgery, regularity index of corneal surface and surface asymmetry index in TG-LASIK group were significantly lower than those in SMILE group and FS-LASIK group (P<0.05), and there was no significant difference between SMILE group and FS-LASIK group (P>0.05). ③At 6months after surgery, total HOA, coma, clover aberration and spherical aberration in FS-LASIK group were significantly higher than those in TG-LASIK group and SMILE group (P<0.05). ④At 6months after surgery, contrast sensitivities with or without glare in TG-LASIK group were significantly higher than those in SMILE group and FS-LASIK group at frequencies of 12.0c/d and 18.0c/d (P<0.05). Conclusion The curative effect of FS-LASIK, TG-LASIK and SMILE are satisfactory. However, the aberration increase is less after TG-LASIK, the corneal topography is more regular, and the visual quality is higher.]]> 2021/7/7 14:45:37 2021/7/7 11:25:45 2021/7/6 9:25:10 0.05 ) .There was no increase in OSI (P=0.862), both MTF and SR were higher than that of SMILE preoperatively(P<0.05). CONCLUSION:SMILE demonstrated to be safe, effective, and predictable in treatment of myopia and myopic astigmatism, and good accuracy in correcting medium and low astigmatism.The post-quality of retinal image is better than that of SMILE preoperatively .]]> 2021/7/6 9:15:58 2021/7/2 16:36:39 0.05).Retinal thickness in the inner ring in the both groups increased significantly postoperatively, which was statistically significant (P<0.001）. In the study group, the macular thickness in the inner ring increased slightly 1 week postoperatively, which was no statistical difference (P=0.057).The inner ring thickness at 1 month increased significantly compared with preoperatively and 1 week postoperatively, and the differences were statistically significant ( P<0.001);In the control group, the inner macular ring was significantly thicker at 1 week and 1 month (P<0.001), and the thickness at 1 month was higher than 1 week, which was statistical difference(P=0.017) .2. Comparison between the two groups: the thickness of macular in the inner ring in the control group was significantly higher than the study group 1 week and 1 month postoperatively, which was statistically significant (t1 week=6.233，t1 month=7.055,P<0.05). Conclusions: Femtosecond laser does not increase the risk of macular damage during operation. Femtosecond laser-assisted cataract surgery is less inflammation and lower macular edema in early, which is a safe surgical option.]]> 2021/7/2 11:25:51 2021/7/2 10:18:26 2021/7/2 9:45:44 2021/7/2 9:16:37 2021/7/1 14:17:02 2021/7/1 9:18:01 2021/6/30 9:23:57 2021/6/29 15:43:20 2021/6/29 9:14:35 2021/6/28 14:05:45 2021/6/28 10:57:42 2021/6/28 10:32:19 2021/6/28 10:31:42 2021/6/25 17:00:07 2021/6/25 9:10:17 2021/6/24 10:21:48 2021/6/18 10:58:31 0.05). The overall Coma, SA, trefoil and HOA of the two groups were significantly increased at 1 month after surgery (P<0.05), and the overall SA, trefoil and HOA in SMILE group were lower than those in FS-LASIK group (P<0.05). At 1 month after surgery, the OSI of the two groups was significantly increased (P<0.05) while the MTFcutoff, SR, VA100%, VA20% and VA9% were significantly reduced (P<0.05), and the OSI in SMILE group was higher than that in FS-LASIK group while the MTFcutoff and VA9% were lower than those in FS-LASIK group (P<0.05). The corneal higher order aberrations of overall Coma, SA, trefoil and HOA in patients with high myopia after surgery were significantly negatively correlated with MTFcutoff (P<0.05), and were significantly positively correlated with OSI (P<0.05). CONCLUSION Compared with FS-LASIK, SMILE can effectively correct refractive errors in the treatment of high myopia, and SMILE is also beneficial to reduce early postoperative corneal HOA and relieve visual quality impairment.]]> 2021/6/4 11:13:16 0.05). After treatment, the TCM syndromes scores in observation group were lower than those in control group, and the BUT time was longer than that in control group, and the SIT level was higher than that in control group, and the FL score and NEI-VFQ-25 scores were lower than those in control group (P<0.05). Conclusion Qiju Dihuang decoction combined with sodium hyaluronate eye drops has exact efficacy in treating xerophthalmia after cataract surgery, and it can effectively alleviate the symptoms of ocular discomfort, improve tear film function, and promote the quality of life of patients. Thus it is worthy of clinical promotion.]]> 2021/6/4 11:07:01 2021/6/4 9:32:31 2021/6/3 15:42:52 2021/6/3 10:17:41 2021/6/3 9:22:57 2021/6/2 16:19:36 0.05). The ablation center deviation in the CV group was 0.20±0.13mm, which was smaller than ablation center deviation in the VACRP group 0.27±0.14mm (t=2.91, P<0.01). TotHOA, totZ40, totZ3-1, and totZ31 in CV group were lower than those in VACRP group (P<0.05). The total corneal high order aberration totHOA, total high order aberration change ΔtotHOA, spherical aberration totZ40, and vertical coma totZ3-1 after surgery in the VACRP group were correlated with the ablation center deviation (r=0.470, 0.486, 0.254,- 0.366, P<0.001, =0.001, 0.037, 0.002). The postoperative corneal horizontal coma totZ31 was correlated with the ablation center deviation in the CV group (r=-0.352, P=0.002). Conclusion: Both VACRP and CV group have restored satisfactory uncorrected visual acuity as well as the same level of refractive diopter. But the SMILE operation using CV as the ablation center can reduce postoperative the ablation center deviation and high order corneal aberrations, and obtain better visual quality.]]> 2021/6/2 13:53:09 2021/6/2 10:16:29 0.05). In group B, the UIVA at 60cm were better than in group A (P<0.05), and UNVA were significantly better than in group A (P<0.01). The defocus curve analysis revealed that the group A tended to be stable between +1.0D to -2.0D, and to form a platform, while the group B had double peaks (0D and-2.5D). The visual acuity at 0D were no significantly differences between the two groups (P>0.05), but at -2.5D and -3.5D in group B were significantly higher than in group A (P<0.01). Patients in the two groups showed different degree of halo, glare and other optical phenomenas, but the overall satisfacation were higher. The scores of satisfacations for reading speed and night vision were significantly better in the group A than in the group B (P<0.05). Conclusion In both groups over 90% patients were spectacle independent, they can obtain good near，intermediate and far distance VA. Symfony IOL has better continuous intermediate distance VA, patients can obtain higher satisfaction and have better night vision. The At Lisa tri 839 MP IOL implantation was is associated with significantly better near VA, and it is more suitable for near vision.]]> 2021/6/2 9:20:31 2021/6/1 10:32:26 2021/6/1 9:37:45 2021/5/31 9:57:27 0.05). CONCLUSION:Compared with Nagahara phaco-chop technique,press-and-chop technique is simple and safe with less complications．]]> 2021/5/31 9:49:48 2021/5/28 16:12:33 2021/5/28 9:29:26 2021/5/28 9:21:59 2021/5/28 9:16:28 2021/5/28 9:09:45 2021/5/26 9:21:54 2021/5/25 9:45:15 2021/5/25 9:33:00 2021/5/25 9:14:52 2021/5/10 9:42:54 2021/5/8 14:03:49 2021/5/8 11:45:22 2021/5/8 9:41:43 0.05). Conclusion: over accumulation of ATRA induces ERS in ARPE-19 cells and activates perk-eif2 α - ATF4 and IRE1 α - XBP1 signaling pathways Keywords: ATRA, RPE cells, ERS]]> 2021/5/8 9:27:38 2021/5/7 14:39:35 2021/5/7 9:58:53 0.05). The total high-order aberration(HOA) and RMS of the whole eye after ICL were significantly reduced, and there was a significant difference compared with that before operation (F=9.204, 27.028.P<0.001); there was no statistical difference after surgery. The MTF and SR value were significantly higher than before surgery (F=14.438, 12.094.P<0.001), and there was no statistical difference after ICL. At 3 months after surgery, the RMS and MTF values at 3 mm and 5 mm pupils were compared. The RMS value of the total HOA under the pupil of 5mm is significantly higher than that at 3mm, and the increase of spherical and trefoil aberration is significant (t=21.812, 17.136, P<0.001). no significant difference in coma value(t=2.028,P>0.05). The MTF at 5mm pupils were significantly lower than those at 3mm at spatial frequencies of 5, 10, 15, 20, 25, 30c/d (t=15.138, 9.147, 7.018, 4.693, 3.814, and 3.075, all P values<0.05 ). Conclusion 1. The impact of pupil movement on vault height fluctuation is about 110?m. It is recommended that the minimum vault height should be above 300?m. 2. It can significantly reduce the root mean square value of total high-order aberration and aberration of the whole eye, and significantly increase the MTF and SR values after ICL surgery. 3. The pupil size has a significant effect on visual quality after ICL. The spherical aberration and trefoil aberration increase under the condition of large pupil, and the MTF value generally decreases.]]> 2021/5/7 9:39:32 2021/5/7 8:45:41 2021/5/6 16:41:01 2021/5/6 11:24:00 2021/4/30 14:15:36 50 y, n=27) and group B （young and middle-aged group, age ≤ 50 y, n=20). All patients were received anti-VEGF therapy(3+PRN) and followed up for at least 12 mo. The best corrected visual acuity (BCVA),the number of hyper-reflective dots (HRD),the average retinal thickness (ART) and central retinal thickness (CRT) were observed before and after treatment. The number of injections, the recovery rate of outer membrane (ELM) and ellipsoidal zone (EZ) were compared between the two groups, and the related indexes affecting visual prognosis were analyzed. RESULTS: After anti-VEGF treatment, BCVA was improved, the number of HRD decreased, CRT and ART thinned in both groups. During the follow-up of 12 months after treatment, the frequency of injection of anti-VEGF drugs in the elderly group was higher than that in the young and middle-aged group (8.4 ±2.1times vs 7.3times, P=0.047), but there was no difference in the recovery rates of ELM and EZ between the two groups. BCVA in the elderly group was correlated with the age, HRD, ELM and EZ (all P < 0.05). BCVA was correlated with age, ART, HRD, ELM and EZ in young and middle-aged patients. CONCLUSION: Intravitreal injection of anti-VEGF drugs can effectively treat macular edema secondary to CRVO and the prognosis of young and middle-aged patients is better than that of elderly patients. Age and OCT indexes such as HRD, ELM and EZ are related to visual prognosis.]]> 2021/4/29 16:14:23 2021/4/29 9:15:13 2021/4/29 8:58:08 2021/4/29 8:47:25 2021/4/27 10:06:31 0.05). CONCLUSION：Topical application of rhGH can accelerate the early stage of rabbit corneal epithelial wound healing in vivo.]]> 2021/4/27 9:33:33 2021/4/26 15:55:03 2021/4/25 10:03:25 2021/4/23 9:26:24 2021/4/23 9:13:44 2021/4/22 10:27:41 2021/4/8 14:56:05 2021/4/7 9:36:40 2021/4/7 9:20:17 2021/4/6 10:10:30 2021/4/6 9:47:17 2021/4/2 14:08:13 2021/4/2 9:46:04 2021/4/1 17:19:51 0.05). After a single-dose injection, the regression of ROP occurred in 85 eyes (93.4%) treated with IVC and in 95 eyes (87.2%) treated with IVR, and there was no statistically difference between the two groups (P>0.05). A total of 6 eyes (6.59%) developed ROP recurrence in the IVC group, in which 2 eyes received a second IVC, and 4 eyes were treated with laser photocoagulation (LP). In the IVR counterpart, 11 eyes (10.1%) developed ROP recurrence, among them 4 eyes underwent another IVR, and 11 eyes were treated with LP. The recurrence interval was 11.7?4.13wk and 8.62?4.70wk in the IVC and IVR groups. All these results of recurrence showed no significant statistical difference between these two groups (P>0.05). There was no progression of ROP appeared in IVC group. The progression of ROP developed in 3 eyes after initial ranibizumab injection, among them retinal fibrous proliferation and hemorrhage treated with LP in 2 eyes, and tractional retinal detachment treated with vitrectomy in 1 eye. No drug or injection related side effect was observed in infants of both groups. There were some adverse prognosis, such as temporal retinal folds, smaller angle between upper and lower temporal retinal vessel trunks caused by retinal vascular traction in 3 eyes in IVR group during the long-term follow-up. ?CONCLUSIONS: Both IVC and IVR are effective and safety choices for the treatment of ROP. There was no significant difference between the first cure rate and the recurrence rate. Some of the most severe cases treated by IVR were at risk for progression or poor prognosis, that need to be followed up for a long time.]]> 2021/4/1 9:03:31 2021/3/31 9:19:21 0.05). CT of all sites were negatively correlated with axial length (AL). N 2 mm and I 2 mm were also negatively correlated with age, anterior chamber depth (ACD), SFCT was negatively correlated with age and AL ( B < 0, P < 0.05). Multivariate logistic analysis showed that there was an association between S 2m and APACG (P=0.029),the odds ratio (OR) and 95％ confidence interval(CI) was 0.975（0.953,0.997). There was no association between CPACG and CT at all locations (P＞0.05). CONCLUSION: Age, AL and ACD were the factors that related to choroidal thickness. It was also confirmed that there was an association between decreased S 2m and APACG. However, there was no correlation between CPACG and CT at all locations.]]> 2021/3/31 9:09:20 2021/3/30 10:41:37 0.05; The difference in residual accommodation power between the two is WMD: 0.22, 95% CI (-0.13,0.58), P = 0.22> 0.05. The ratio of the incidence of adverse reactions after the use of the two drugs is OR: OR=0.17，95%CI（0.07，0.42），P＜0.01. In addition, cyclopentolate has a lower incidence of adverse reactions and is safer. Conclusion: Compared with atropine, cyclopentolate has equivalent effects on ciliary muscle paralysis in myopic children, and has higher security. Cyclopentolate could replace atropine for myopic children before optometry.]]> 2021/3/30 9:46:02 2021/3/30 9:25:36 2021/3/30 8:47:42 2021/3/29 11:13:19 2021/3/29 10:36:30 2021/3/26 16:06:39 2021/3/26 10:59:05 2021/3/26 10:02:25 2021/3/26 9:31:23 2021/3/25 10:39:34 2021/3/25 9:40:48 2021/3/24 9:49:38 0.05). Compared with empty vector group, clone formation rate, cell healing rate, number of invasive cells per unit area, relative expression levels of Ki67, N-cadherin and TGF-β were significantly decreased in transfection group (P<0.05). Compared with empty vector group, there were no significant differencess in apoptosis rate, relative expression levels of Bcl-2 and Bax in transfection group (P>0.05). Compared with empty vector group, relative expression level of E-cadherin protein was significantly increased in transfection group (P<0.05). Conclusion HSP47-siRNA can reduce proliferation, invasion and migration abilities of HTCF by inhibiting the expression of TGF-β1 protein, without significant effect on HTCF apoptosis.]]> 2021/3/12 9:47:58 2021/3/11 9:13:09 2021/3/10 9:09:38 2021/3/9 9:12:23 0.05) Compared with glaucomatous cataract, the MTFcut off of uveitis cataract was lower (P=0.028), but higher than that of fundus cataract (P= 0.043), and diabetic cataract (P= 0.001).The MTFcut off value of glaucomatous cataract was higher than that of fundus cataract (P=0.001),and diabetic cataract (P<0.001)；the MTFcut off of fundus cataract was higher than that of diabetic cataract and there was significant difference (P=0.01). Conclusion There is no significant difference in the ocular surface and visual quality between complicated cataract and aged cataract in general, while there are some differences in the ocular surface and visual quality parameters of each subtype of complicated cataract, especially MTFcut off, so we should paid attention to the cataract types before surgery.]]> 2021/3/8 10:18:35 2021/3/5 9:54:01 2021/3/5 9:47:07 2021/3/5 9:14:38 2021/3/4 10:18:38 2021/3/4 10:08:53 2021/3/3 11:11:22 2021/3/3 9:34:41 2021/3/2 11:10:08 0.05). At 6 mo and 1 a postoperative, Km of anterior corneal curvature (48.54±2.57, 48.77±2.29 D) are decreased significantly, the first flatten width of corneal biomechanical parameters (1.52±0.21, 1.57±0.22 mm) were significantly lower (P < 0.05), The absolute value of the second flattening velocity (0.82±0.09, 0.82±0.18m/s) was significantly increased (all P < 0.05). CONCLUSION: Accelerated transepithelial-corneal collagen cross-linking surgery for progressive keratoconus can significantly improve the uncorrected visual acuity and corneal biomechanics postoperative, but the best corrected visual acuity was not significantly improved.]]> 2021/3/1 15:26:59 2021/3/1 14:40:54 2021/3/1 14:39:55 0.05).The RPR of the control group showed an increase in hyperopia.1 year later,there were statistical differences in the changes of AL and RPR between the two groups(p<0.001). There was a positive correlation between the changes of AL and RPR in the experimental group(p<0.001). Conclusion After wearing OK lens,the AL growth slowed down,while the RPR showed myopic drift and it was most obvious in 1 month. There was a correlation between the changes of AL and RPR.]]> 2021/2/26 9:24:13 2021/2/25 15:32:37 2021/2/25 14:33:42 2021/2/25 11:18:41 2021/2/25 9:15:04 2021/2/24 10:09:59 2021/2/24 9:31:25 2021/2/20 16:30:43 -6.00d), and high myopia group (≤-6.00d). All data were statistically analyzed using SPSS 16.0. RESULTS: Among 2760 new recruits,340 persons (12.3%) had undergone corneal refractive surgeries, which included corneal stroma surgery (89.7%) and corneal surface surgery (10.3%). In comparison of contrast sensitivity of three different diopter groups under natural light and glare conditions, there was no statistically significant difference between the low and moderate myopia groups. However, the difference between the high myopia group and the low, or moderate myopia group was statistically significant (P<0.05). The visual-related quality of life scores were statistically significant among the three groups (P<0.05). The scores of low (6.25? 8.61) and moderate myopia groups (6.87? 8.51) were significantly better than that of high myopia group (9.84 9.76). CONCLUSION: The Vision-related Quality of Life in new recruits after corneal refractive surgery in the unit is related with preoperative diopter of refractive error. And its cores in the mild and moderate myopia groups are better than in the high myopia group.]]> 2021/2/3 16:36:13 0.05). At 1 wk after surgery, VEGF-A, SDF-1 and PEDF in both groups were decreased (P<0.05), which were lower in combination group than surgery group (P<0.05). The incidence of iatrogenic tear and vitreous re-hemorrhage in combination group was lower than that in surgery group (P<0.05). There was no significant difference in the incidence of remaining complications between the two groups (P>0.05). Conclusion: The overall value of 23G minimally invasive vitrectomy combined with ranibizumab vitreous injection in the treatment of PDR is better than that of 23G minimally invasive vitrectomy alone, which can reduce surgical difficulty, shorten operation time, reduce intraoperative bleeding and instrument operation, promote recovery of postoperative visual acuity, inhibit retinal neovascularization, and reduce the risks of iatrogenic injury, with fewer complications, higher safety and effectiveness.]]> 2021/2/3 9:49:38 2021/2/3 9:08:42 0.05). Conclusion: The overall value of loratadine combined with diclofenac sodium eye drops in the treatment of allergic conjunctivitis is better than that of loratadine alone, which can improve symptoms, signs and tear film stability, reduce the concentrations of inflammatory mediators in tears, and promote recovery of tear film function. It is safe and feasible.]]> 2021/2/2 16:06:58 2021/2/2 14:38:19 0.05). After surgery, DES scores in both groups were significantly increased, BUT was decreased compared with that at 1d before surgery. At 3 months after surgery, SDES and BUT recovered to preoperative levels. At 1d and 1 week after surgery, DES score in group A was significantly lower than that in group B , while BUT was significantly higher than that in group B ( P<0.05). After surgery, BCVA LogMAR and ECD in both groups were significantly decreased, while SE and corneal diopter were significantly increased, without significant difference between the two groups (P>0.05). Conclusion The curative effect of phacoemulsification through clear corneal tunnel incision is reliable on cataract. The tear film function is better through 2.2mm micro-incision.]]> 2021/2/2 9:31:51 0.05).Intraocular pressure:Intraocular pressure in the two groups was within the normal range (10mmHg~21mmHg) at 7 ,30 and 60 days after surgery, and there was no statistically significant difference between the groups (P > 0.05),while the difference between the groups was not statistically significant. Corneal astigmatism:At 30 days after surgery, the corneal astigmatism of the two groups was both increased than before, at 60 days after surgery,the corneal astigmatism of the control groupwas increased than before,and the differences were statistically significant (P<0.05).The corneal astigmatism of research group at 30 and 60 days after surgery was significantly lower than control group (P<0.05).The tilt and decentration of the IOL: The tilt and decentration of the IOL of research group at 30 and 60 days after surgery was significantly lower than control group (P<0.05). Conclusion：Surgical respositioning of spontaneous in-the-bag intraocular lens dislocated into the vitreous cavity provides efficacy and predictability and is safe and reliable. Keywords：Intraocular lens;In-the-bag intraocular lens;Dislocation;Vitrectomy]]> 2021/2/1 16:29:19 2021/2/1 11:00:21 2021/2/1 10:28:16 0.05）. The value of central corneal thickness (CCT) was significantly increased on postoperative day 3 and day 6 compared with the preoperative parameter（P<0.05）. The value of CCT got the maximum value on the 3rd day after surgery, and recovered to the preoperative level on the day 30 after surgery. CONCLUSION Phacoemulsitication with 2.4mm corneal incision change the corneal biomechanical preoperties . The corneal biomechanical parameters are basically recovered in the post operative 30 days. Key words: Corneal biomechanics; Phacoemulsitication; Corneal visualization Scheimpflug technology]]> 2021/1/29 10:19:26 2021/1/28 17:08:26 0.05). The logMAR best corrected visual acuity (BCVA) was significantly better in the control group than that in the ROP group (0.07±0.10 vs 0.24±0.25, p=0.001). Conclusion：The development of eye anterior ganglion tissues of the ROP group had changed with steeper cornea, shallower anterior chamber ,Smaller angle of the anterior chamber and poor BCVA. All of the changes above might make it easier for the development of refractive errors and glaucoma.]]> 2021/1/28 13:48:37 2021/1/27 14:23:59 2021/1/27 14:13:44 2021/1/26 16:03:19 2021/1/26 9:54:26 2021/1/25 14:17:20 2021/1/25 11:42:20 2021/1/25 11:08:20 2021/1/25 10:57:26 2021/1/22 17:03:31 2021/1/22 10:02:40 2021/1/21 14:46:30 0.05). Conclusions: Yijing Buyang Huanwu Decoction combined with timolol maleate eye drop can effectively improve the blood supply, intraocular pressure and vision of patients with OAG, it can improve the efficacy, and it has the good safety, it’s worth for further clinical promotion.]]> 2021/1/7 9:51:57 2021/1/6 9:27:11 2021/1/6 9:17:33 2021/1/5 16:57:48 0.05). After 12 weeks of treatment, the proptosis degree and CAS scores decreased, the visual acuity was improved and the conscious diplopia was improved (P<0.05). The ocular apex distance, retrobulbar perimeter, area and volume were smaller than those in the same group before treatment (P<0.05). After 12 weeks of treatment, the proptosis degree and CAS scores of the glucocorticoid group and the cyclophosphamide group were lower than the octreotide group, and the grades of conscious diplopia was better than the octreotide group (P<0.05). The ocular apex distance, retrobulbar perimeter, area and volume were smaller than the octreotide group (P<0.05). After 12 weeks of treatment, the TRAb, TPOAb and thyroid volume in the glucocorticoid group and the cyclophosphamide group were lower than the octreotide group (P<0.05), without statistically significant difference between the glucocorticoid group and the cyclophosphamide group (P>0.05). The incidence rates of hypertension and weight gain and the total incidence of adverse reactions in the glucocorticoid group were higher than those in the cyclophosphamide group and the octreotide group (P<0.05), without statistically significant difference between cyclophosphamide group and the octreotide group (P>0.05). Conclusion: The overall curative effect of glucocorticoids and cyclophosphamide in the treatment of GO is better than octreotide, and the improvement of ocular signs and thyroid-related lesions is better than octreotide. However, the incidence of adverse reactions caused by cyclophosphamide is lower than glucocorticoids, and the safety is higher. It is first choice for treatment of GO.]]> 2021/1/5 15:35:11 0.05). ② At 6 months after surgery, the BUT in conjunctival transplantation group was longer than that in the amniotic membrane transplantation group [(11.11 ? 2.77) s vs (10.01 ? 2.41) s] (P<0.05), and the FL score was lower than the amniotic membrane transplantation group [(0.44 ? 0.10) points vs (0.50 ? 0.11) points] (P<0.05). ③ The conjunctival goblet cell counts in both groups were increased significantly after surgery (P<0.05). At 3 months and 6 months after surgery, the counts in conjunctival transplantation group were larger than those in the amniotic membrane transplantation group [(311.41 ? 58.45)/mm2 vs (285.46 ? 68.96)/mm2, (342.41 ? 66.89)/mm2 vs (314.41 ? 70.12)/mm2] (P<0.05). ④ The ODSI scores of both groups were significantly decreased after surgery (P<0.05), but there was no significant difference between groups (P>0.05). ⑤ There was no statistically significant difference in the overall curative effect between the two groups (P>0.05). The recurrence rates in the conjunctival transplantation group and the amniotic membrane transplantation group were 5.88% and 6.06%, respectively (P>0.05).Conclusion: Pterygium resection combined with autologous conjunctival flap transplantation is equivalent to amniotic membrane transplantation in terms of postoperative recovery and prevention of pterygium recurrence. Both can improve the stability of patients’ tear film function.]]> 2021/1/5 9:06:48 0.05).And also, there were no significant difference in VF-14-CN questionnaire score, degroscopy rate and satisfaction between the two groups (P>0.05). •CONCLUSION: Patients who accepted AT LISA tri 839MP in both eyes and who accepted AT LISA tri 839MP in one eye and an aspheric monofocal IOL in the other eye, share excellent bUCDVA、bUCIVA、bUCNVA.There was no significant difference in postoperative vision-related QoL, spectacle independency and satisfaction between the two groups. For patients who are not suitable for the implantation of trifocal IOL at one eye or who have had the aspheric single-focus IOL implanted at the previous eye, trifocal IOL implantation at another eye can be considered to meet the requirements of the whole binocular vision.]]> 2021/1/4 16:42:21 0.05). The dramatically reduced microvilli of RPE cells were also observed in experimental groups using TEM. Furthermore, residual microvilli were shortened. The expression of Tuj1 was decreased in ganglion cell layer (GCL), NFL and IPL, but no significant changes in the number of retinal ganglion cells were shown among three groups (P>0.05). In addition, the increased expression of 8-OHdG was observed in GCL and inner nuclear layer (INL) in experimental groups, but there was no significant difference between two experimental groups (P>0.05). CONCLUSION: E-cigarette can lead to the retinal damages in mice, which might be due to oxidative stress.]]> 2021/1/4 11:41:02 2021/1/4 11:33:05 0.05). The diopter of the two groups decreased gradually during the treatment, and the diopter of the children in the under correction group decreased significantly higher than that in the full correction group(F time = 500.299, P time = 0.000, F group = 6.949, P group = 0.010). The reduction of hyperopia in the under correction group was 1.215 ± 0.262D, and 0.612 ± 0.211D in the full correction group. The hyperopia reduction was significantly higher in the under correction group(t=-12. 068, P=0. 000). The corrected visual acuity of the two groups increased with the prolongation of treatment time. The improvement of visual acuity in the under correction group was significantly better than that in the full correction group(F time = 1138.526, P time = 0.000, F group = 14.206, P group = 0.000). Conclusion The hyperopia reduction and vision improvement of children with under correction were better than that with full correction. Suitably under correction of hyperopia can better promote the eye growth and vision improvement of children with high hyperopia and amblyopia.]]> 2021/1/4 10:53:49 2020/12/31 14:58:57 2020/12/31 10:42:17 2020/12/30 9:33:19 2020/12/30 9:23:16 0.05). The UCVA (LogMAR) was positive correlative to the RA (r = 0.350, P < 0.05) and IOL rotation (r = 0.369, P < 0.05), and was negative correlative to the MTF total value (r = -0.290, P < 0.05); the RA was positive correlative to the IOL rotation (r = 0.431, P < 0.05). Conclusion: The accuracy of the axis alignment was significantly higher in the FLACM group, which results in lower residual astigmatism and better visual outcome.]]> 2020/12/29 14:02:42 2020/12/29 10:57:03 2020/12/28 14:59:14 2020/12/28 14:46:38 2020/12/28 14:39:03 2020/12/24 10:17:04 180° before LPI and 9 eyes(40.9%) were ≤180° after LPI.The intraocular pressure of 21 eyes (95.5%) had significantly lower than postoperative (P<0.05). Postoperative anterior chamber parameters such as ACA,ACV and PACD were increased(P<0.05) except CACD (P>0.05).During the operation,15 eyes (68.2%) had iris cascade or silk hemorrhage and 5 eyes (22.7%) had corneal epithelial damage. Conclusion：LPI has high safety and can be implemented in the acute attack stage of drug-uncontrollable PACG.It can reduce intraocular pressure effectively and relieve symptoms,which has a significant effect in the patients.]]> 2020/12/24 10:16:32 2020/12/23 15:46:51 2020/12/23 15:39:12 2020/12/21 14:43:26 2020/12/21 14:29:30 0.05).MGE and LLT of both groups increased.The increase in the control group was slower than that in the experimental group.MGE of the experimental group was higher than that of the control group after the second and third treatment,with statistical significance(P<0.05).BUT of both groups increased.BUT of the experimental group was higher than that of the control group at the last follow-up,with statistical significance(P<0.05).Corneal staining in both groups decreased,and it decreased more in the experimental group than in the control group,with no statistical significance between the two groups(P>0.05).The visual quality in the two groups improved,but in improving visual quality the experimental group was much better than the control group.However,there was no statistical significance between the two groups(P>0.05).There was no significant change in tear secretion,incomplete blink ratio and meibomian gland loss rate in the two groups(P>0.05).There were no skin and visual impairment,intraocular pressure change,anterior segment inflammation and other complications in all subjects. Conclusion:IPL combined with meibomian gland expression and meibomian gland expression alone are both safe and effective.IPL,which has good,rapid effects and cumulative effects,works better after reaching a certain number of treatments.]]> 2020/12/9 13:48:37 0.05). There was significant difference in corrected visual acuity and the height of lacrimal river between the two groups after operation (P < 0.05)，and the control group was higher than the experimental group. There was no difference in intraocular pressure between the two groups after operation (P > 0.05). There were significant differences in corrected visual acuity and lacrimal river height between experiment group and before operation (P < 0.05)，and it was higher after operation than before. There was no significant difference in intraocular pressure in group A between preoperation and after operation (P > 0.05). There was no significant difference in corrected visual acuity, lacrimal river height and intraocular pressure between control group (P > 0.05). SPEE was observed in experiment group after operation, but not in control group and experiment group before operation. There was no significant difference in the scores of ocular symptoms before operation between the two groups (P > 0.05); there was significant difference in the scores of ocular symptoms after operation between the two groups (P < 0.05). The scores of ocular symptoms after operation in experiment group were significantly different from those before operation (P < 0.05)，and it was higher after operation than before; there was no significant difference in the changes of ocular symptoms in control group (P > 0.05). There was no significant difference in OSDI score, SIt and CSF score between the two groups before operation (P > 0.05); there was significant difference in OSDI score, SIt and CSF score between the two groups after operation (P < 0.05)，and OSDI and CSF scores were higher in the experimental group，SIt was lower. There were significant differences in OSDI score, SIt and CSF score in experiment group between between preoperation and after operation (P < 0.05)and OSDI and CSF scores were higher after operation，SIt was lower , while there was no significant difference in OSDI score, SIt and CSF score in control group between operation and preoperative (P > 0.05). Conclusion Vitreous injection of Conbercept in the treatment of diffuse diabetic macular edema can damage the ocular surface.]]> 2020/12/9 9:25:51 2020/12/7 14:40:16 2020/12/7 10:22:34 2020/12/7 10:17:15 2020/12/7 9:48:27 2020/12/4 11:25:29 2020/12/4 9:59:34 0.05).Follow up for 6 mons.: the effective rate of group A was 86% while group B was 71%; no difference presented between the two groups (P＞0.05); No nasal adhesion was found in group A while 12% incidence existed in group B, with no difference between the two groups (P> 0.05). Conclusion: Patients who have chronic dacryocystitis combined with mild or moderate NSD do not need to perform a septoplasty simultaneously if the symptom does not accompany by nasal dysfunction. Only by performing the EES-DCR can achieve a quite good result.]]> 2020/12/4 9:54:43 2020/12/4 9:48:43 0.05). In addition, the angle of the diseased eyes in the age group of 41-60 years [25.20°（17.90°，33.00°）] was significantly higher than that in normal eyes [21.60° (15.25°, 29.05°)] (P < 0.05). CONCLUSION: The angle between the long axis of lacrimal sac and bony nasolacrimal duct increased in patients with chronic dacryocystitis, which may be one of the factors causing the onset of chronic dacryocystitis in middle-aged and elderly women. KEYWORDS : Chronic dacryocystitis; Computed tomography dacryocystography; Bony nasolacrimal duct; Lacrimal sac; Lacrimal sac-BNLD angle]]> 2020/12/4 9:42:20 2020/12/3 17:08:51 0.05),CRT(2d VS. 1w,P>0.05),BCVA(2w VS. preoperation,P>0.05).There are four forms of EZ and ELM::9 eyes,intact ELM and EZ (EZ+ELM+);B:7 eyes,intact ELM with disrupted EZ:( EZ-ELM+);AC:6 eyes,intact EZ with disrupted ELM:(EZ+ELM-);D:8 eyes,disrupted ELM and EZ:(EZ-ELM-),the BCVA of the above four types are 0.15 ± 0.04,0.50 ± 0.06,0.54 ± 0.05 and 0.59 ± 0.09,there were significant difference in each groups except (C VS. B,P>0.05) and (C VS. D,P>0.05). The incidence of SRF was 86% 2 days after operation,46.6% patients had persistent SRF at 6 months after operation. Postoperative CRT was positively correlated with postoperative SRFH.Conclusion After scleral buckling,the macular microstructure showed dynamic changes. The effect of SRF may be manifested as BCVA delayed recovery. With the slow absorption of SRF, CRT decreased and BCVA increased.The intact ELM or EZ shows better vision,but the disrupted ELM means worse vision.]]> 2020/12/2 17:13:10 2020/12/2 15:56:47 2020/12/2 9:18:13 2020/12/2 9:05:23 2020/12/1 14:50:17 0.05). The rate of distant vision defecation and visual quality were significantly improved. Conclusion Pentacam can evaluate the corneal astigmatism more comprehensively and accurately, which is helpful to guide the accurate selection of Toric artificial lens model, and to improve the postoperative expected effect.]]> 2020/12/1 9:51:14 0.05). The main complications were: false passage formation(16eyes, 10.13%), loss of tube(14eyes, 8.86%), red eyes and irritated tears(18 eyes, 11.39%), punctums tissue adhesion(3eyes, 1.90%), punctum granuloma formation(1eyes, 0.63%). • CONCLUSION: Endoscopic-assisted RS silicone intubation has a higher effective rate and better safety in the treatment of congenital nasolacrimal duct obstruction after failed probing in children. The effective rate of surgery decreases with age, and decreases with the increase of the times of probing. Membranous nasolacrimal duct obstruction is more effective than complicated nasolacrimal duct obstruction.]]> 2020/11/27 9:33:50 2020/11/26 9:53:04 0.05).After treatment, the number of Demodex in the three groups were significantly reduced(P<0.05),and there were significant differences between group C, group A and group B(P<0.05).The scores of subjective symptoms and signs of the three groups were significantly improved after treatment (P<0.05),and the improvement of group C was more significant than that of group A and group B (P < 0.05).After treatment, tear break-up time of the groups B not significantly improved, tear break-up time that of group C was significantly longer than that of group A and group B(P<0.05);Fluorescent staining scores of three groups before and after treatment were significantly improved (P<0.05).The statistical results of group C were better than those of group A and group B,but there was no difference between the three groups.No obvious complications occurred in all patients. Conclusion：The effect of optimal pulse technology combined with tea tree essential oil in the treatment of acariasis blepharitis is significant,which is significantly better than that of single optimal pulse technology therapy and single use of tea tree essential oil.]]> 2020/11/26 9:44:27 2020/11/26 9:32:17 2020/11/25 9:30:02 2020/11/24 17:04:54 2020/11/24 9:23:50 0.05). The intraocular pressure in CM1 group was lower than that in CM2 group at 1 month, 2 months and 3 months after treatment (P<0.05). The average number of injections in CM1 group was larger than that in CM2 group, and the first injection interval of CM1 group was shorter than that CM2 group (P<0.05). During the follow-up period, no serious complications such as cataract exacerbation, retinal detachment or endophthalmitis occurred. Conclusion: The treatment of CRVO-ME with anti-VEGF drugs (ranibizumab) can significantly improve patients’ visual acuity, reduce CMT and intraocular pressure. The condition can be significantly improved within 1 month after injection. Compared with patients over 50 years old, patients under 50 years old have better results after treatment with ranibizumab. The improvement of visual acuity and thinning of CMT are more obvious in the latter, and the first injection interval is shorter.]]> 2020/11/11 14:01:55 0.05). Conclusion: Giemsa staining can accurately diagnose bacterial conjunctivitis in children, and is simple and convenient, HE and Giemsa staining both have good diagnostic effect on allergic conjunctivitis, it can provide evidence for improving the clinical diagnosis efficiency and early treatment regimen.]]> 2020/11/10 11:30:43 2020/11/10 9:23:47 2020/11/9 10:41:35 2020/11/6 10:51:26 2020/11/6 9:28:09 0.05). For criterion A: complete success rates in PXG group at 6 months, 1 and 2 years after surgery were 50%, 40% and 29.4% respectively, qualified success rates were 90%, 80% and 73.5% respectively, and complete success rates in POAG group were 84.8%, 63.6% and 61.4% respectively, qualified success rates were 91.3%, 86.4% and 81.8% respectively. The qualified success rates at 6 months, 1 and 2 years after surgery in PXG group were lower than that of POAG group (P > 0.05), while the complete success rates at 6 months, 1 and 2 years after surgery in PXG group were lower than that of POAG group (P < 0.05, P=0.001, 0.030 and 0.005). Criterion B: complete success rates in PXG group at 6 months, 1 and 2 years after surgery were 45%, 30% and 17.65% respectively, qualified success rates were 70%, 70% and 58.8% respectively, and complete success rates in POAG group were 78.3%, 61.4% and 54.5% respectively, qualified success rates were 80.4%, 79.5% and 75% respectively. The qualified success rates at 6 months, 1 and 2 years after surgery in PXG group were lower than that of POAG group (P > 0.05), while the complete success rates at 6 months, 1 and 2 years after surgery in PXG group were lower than that of POAG group (P < 0.05, P=0.001, 0.004 and 0.001). Conclusion: the combined glaucoma-cataract surgery in PXG and POAG patients can significantly improve visual acuity and reduce intraocular pressure. The short-term success rates of both types of glaucoma were similar, however the long-term success rates of PXG patients was significantly lower, and it was difficult to achieve a low level IOP.]]> 2020/11/5 16:50:18 2020/11/5 15:52:06 2020/11/5 14:11:50 2020/11/5 14:02:32 2020/11/5 9:13:46 2020/11/5 9:12:41 2020/11/3 16:03:02 0.05). The uncorrected near visual acuity (UCNVA) at 1 week and 1 month after surgery, distance-corrected near visual acuity (DCNVA), UCNVA and DCNVA at 3 months after surgery in observation group were significantly lower than those in control group (P<0.05). ②After surgery, number of corneal endothelial cells and astigmatism were decreased significantly. There was no significant difference in number of corneal endothelial cells, loss rate of corneal cells or astigmatism between the two groups (P>0.05). ③CS under daytime status in 1.5 c/d, and under daytime glare status in 1.5c/d, 3c/d and 6c/d in observation group was significantly lower than that in control group, while CS under daytime status in 12c/d was significantly higher than that in control group. CS under nighttime status in 3/d and 18c/d, and CS under nighttime glare status in 3c/d, 6c/d and 18c/d in observation group were significantly lower than those in control group. ④There was no significant difference in incidence of complications between the two groups(P>0.05), endoscope-off rate in observation group was significantly higher than that in control group (P<0.05). Results Phacoemulsification combined with filtered diffractive multifocal IOL implantation can obtain good full range of vision, with high endoscope-off rate and relatively low postoperative CS.]]> 2020/11/3 14:55:17 2020/11/3 14:08:17 2020/11/2 14:47:36 0.05).The OSDI scores were (8.02±4.25) and (7.50±4.28) (P = 0.557),TMH values were (0.22±0.05) mm and (0.20±0.04) mm (p=0.158),NIKBUTav values were (8.01±2.15)s and (8.02±1.53)s (p=0.971). Conclusion there was no statistically significant difference between the GDM group and the normal pregnant group in ocular surface indexes.GDM had no negative effects on ocular surface,which may be related to good controlling of The blood glucose.]]> 2020/11/2 11:22:44 2020/11/2 10:11:36 0.05). The adjusted RNFLT of temporal quadrant showed positively correlated with ocular axis length (r=0.220, P<0.01) and negatively correlated with SE(r=-0.386, P<0.001).The adjusted RNFLT of temporal quadrant Y=-2.402AL-3.673SE+118.307. The adjusted RNFLT of nasal quadrant showed positively correlated with ocular axis length (r=0.262, P<0.01) .The adjusted RNFLT of nasal quadrant Y=4.010AL+0.190SE-25.534. The adjusted values of RNFLT at 1-4 o'clock all showed positively correlated with AL(r=0.259, 0.356, 0.237, 0.335, all at P<0.01)and negatively correlated with SE(r=-0.276,-0.307, -0.254, -0.260, all at P<0.01); The adjusted RNFLT at 6, 7 o'clock showed negatively correlated with AL(r=-0.296,-0.327, all at P<0.01) and positively correlated with SE(r=0.245,0.295, all at P<0.01). CONCLUSION: Teenagers' eyeballs are still in the shaping stage. When judging RNFLT in myopic juveniles, effects of ocular magnification effect, AL and SE should be considered.When adjusted temporal RNFLT at 1-4 o'clock are thinner than normal, glaucoma should be considered. KEYWORDS:Myopia;Retina nerve fiber layer thickness;Spectral domain OCT]]> 2020/10/30 11:01:28 2020/10/30 9:16:13 0.05).Two years after the initial diagnosis,the blood flow density of deep retinal layer and choroidal capillaries layer in early AMD patients further increased than before(p=0.02),ISOS-BRM thickness increased further than before(all P<0.18).there was no significant change in the area of macular foveal,perimeter and acircularity index( P>0.05).In addition,the blood flow density of the choroidal capillary layer in early AMD patients was positively correlated with the blood flow density in superficial retinal layer and deep retinal layer at baseline and two years after frist definite diagnosis.Conclusion: Compared with the control group,the macular blood flow density of superficial retinal layer,deep retinal layer and choroidal capillary layer ,and the thickness of inner layer retina in the patients with early AMD decreased significantly,it is clinical reference significance for the early detection and intervention of AMD.]]> 2020/10/28 10:05:04 2020/10/28 9:54:04 2020/10/27 15:58:26 2020/10/14 11:37:01 2020/10/14 9:28:34 2020/10/14 9:18:36 2020/10/13 11:24:27 60 years (OR = 2.611, 95% CI: 1.142 to 5.970), duration of diabetes> 10 years (OR = 6.949, 95% CI: 1.903 to 25.375), history of hypertension (OR = 2.757, 95% CI: 1.037 to 7.330), history of glaucoma (OR=4.041, 95% CI: 1.379 to 11.842), lens core hardness IV to Ⅴ(OR=8.675, 95% CI: 2.622 to 28.702), Qian Qian Atrial (OR=3.755, 95% CI: 1.703 to 8.279) is a risk factor for postoperative corneal edema in patients with diabetic cataract. The risk weights were determined according to the regression coefficients of the risk factors to obtain corresponding scores, and a risk scoring system was constructed: age> 60 years old, history of hypertension, history of glaucoma, shallow anterior chamber corresponding to 1 point, duration of diabetes> 10 years and lens hardness Ⅳ～Grade V corresponds to 2 points, with a total score of 0-8 points. The risk score model predicts the area under the ROC curve of corneal edema in patients with diabetic cataracts at 0.848 (95% CI: 0.772 to 0.934), the optimal cut-off value was 5.84, and the sensitivity and specificity at this time were 85.3% and 80.2%, respectively. Conclusion: The risk score model based on the risk factors of postoperative corneal edema in diabetic cataract patients has great predictive value for postoperative corneal edema, and is simple and convenient, suitable for clinical application.]]> 2020/10/12 14:31:46 0.05). There was significant difference in IOP between pre-operation and post-operation (F=107.23, P < 0.05). There was no significant difference in BCVA between preoperative and postoperative (F=1.66, P > 0.05). The complete success rate was 65.8% and conditional success rate was 86.8%, the failure rate was 13.2%. The main cause of failure was filtering bleb scarring. CONCLUSION: The EX-PRESS miniature glaucoma device implantation has no effect on corneal endothelial cells in five directions and can effectively control intraocular pressure. It is a safe and effective method for primary open-angle glaucoma.]]> 2020/10/12 11:12:42 2020/10/12 9:25:37 2020/10/10 9:19:20 2020/10/9 11:14:00 0.05).In group A, the healing rate of macular hole was 91.3% (21 / 23), and the reoperation rate was 4.3% (1 / 23) before silicone oil removal. After silicone oil removal, no patients recurred to retinal detachment. During the follow-up period, silicone oil removal was completed in all eyes. In group B, the closure rate of macular hole was 65.2% (15 / 23), the rate of reoperation before silicone oil removal was 34.8% (8 / 23), the redetachment rate after silicone oil removal was 26.1% (6 / 23), and the rate of the silicone oil removal throughout the follow-up period was 73.9%(17/23). CONCLUSION：PSR can effectively improve the successful rate of pathological myopic macular holes with retinal detachment and reduce the recurrence and reoperation.]]> 2020/9/30 10:47:22 2020/9/30 10:35:09 2020/9/29 14:45:49 2020/9/29 10:14:03 0.05), and there was no difference in ACD, CRP and AL between the two groups (P > 0.05). At 3 months after operation, the actual SEQ value in the observation group (- 0.426 ± 0.146d) was significantly higher than that before operation (- 0.122 ± 0.037 D) and that of the control group (- 0.127 ± 0.050 D) (all P < 0.001). The refractive error of the observation group was -0.304 ± 0.142 D; the CFT value of the observation group (331.1 ± 67.2 μm) was significantly lower than that before operation (444.8 ± 72.1 μm), but higher than that of the control group (224.7 ± 16.6 μm) The change of CFT in observation group was 113.7 ± 32.2 μm. Correlation analysis showed that the refractive error was positively correlated with the change of CFT at 3 months after operation in the observation group (r = 0.447, P = 0.025). ·CONCLUSION: There was a positive correlation between myopic RE and CFT after Phacoemulsification and intraocular lens (IOL) implantation combined with 23g vitrectomy (PPV). ·KEYWORDS: age-related cataract; vitrectomy; anterior chamber depth; refractive error]]> 2020/9/29 9:35:27 2020/9/29 9:34:32 0.05), but the vitamin C level in the observation group was significantly lower than that in the control group (P<0.05). There was no significant difference in serum MDA level between the observation group and the control group (P>0.05), but the MDA level of aqueous humor in the observation group was significantly higher than that in the control group (P<0.05). Serum and aqueous humor IL-6、IL-8 levels in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in serum VEGF level between the two groups (P>0.05), but the VEGF level of aqueous humor in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: While serum vitamin C、 oxidative stress products and VEGF levels were similar in diabetic cataract patients compared with those in simple cataract patients, there were significant differences in vitamin C、 oxidative stress products and VEGF levels in aqueous humor.]]> 2020/9/28 17:55:19 2020/9/28 10:44:22 2020/9/28 9:45:54 2020/9/27 11:01:48 2020/9/27 10:44:50 2020/9/24 16:25:24 2020/9/23 11:00:55 2020/9/22 14:13:29 2020/9/21 11:45:13 2020/9/9 10:51:11 0.05).The BUT of group 1 was higher than group 2 at post-operative 3d、1wk and 2wk(P<0.05),while there was no difference between the two groups at 3wk postoperative (P>0.05);BUT returned to baseline by 2wk after surgery in group 1 and by 3wk after surgery in group 2.There were no differences between the NIBUT measured by sirius anterior segment analysis system and the BUT measured by traditional method before and after operation(P>0.05).The lowest incidence of dry eye was found at post-operative 2wk and 3wk in group 1(24%、18%).The lowest incidence of dry eye was found at post-operative 3wk in group 2(15%).Besides,the incidence of dry eye in group 2 was higher than that in group 1 at post-operative 2wk(52% vs 24%,P＜0.05). CONCLUSION: There was no obvious influence on the SIT after strabismus surgery;the surgical effect on tear film was mainly reflected in BUT.The fewer muscles operated,the lesser tear film was affected and the tear film was recovered faster.The incidence of dry eye decreased as time went by. KEYWORDS: Strabismus surgery;Tear film;Dry eye;Tear film break-up time;Anterior analysis system]]> 2020/9/7 16:57:06 0.05), and the recurrence rate was less in the cauterization group. There was no difference between the two groups (P>0.05). The family members of the cauterization group were satisfied. Degree (97.33%) is better than the traditional group of 86.67%, but the difference is not large (χ2=1.862.P>0.05). Conclusion: The use of cyst scraping plus povidone-iodine cotton burning can reduce the operation time and hematoma rate of children with meibomian gland cyst, and the curative effect is high, which is worthy of clinical application..]]> 2020/9/7 14:40:33 2020/9/7 10:34:39 2020/9/7 10:29:15 2020/9/7 10:17:18 0.05).Both groups of patients successfully completed the operation and the postoperative eye condition was stable without complications. Three months after the operation, the uncorrected intermediate visual acuity, uncorrected near visual acuity, distance-corrected intermediate visual acuity, distance-corrected near visual acuity of the observation group was significantly better than the control group (P<0.05).The contrast sensitivity of the four spatial frequencies (3c/d, 6c/d, 12c/d, 18c/d) under the conditions of dark, bright, dark dazzling and bright dazzling in the observation group was significantly higher than that in the control group (P<0.05).Compared with the control group, the modulation transfer function cutoff frequency, strell ratio, objective adjustment amplitude and simulated visual acuity under 100%, 20% and 9% contrast were significantly increased in the observation group (P<0.05).Compared with the control group, the VF-12-CN score was significantly decreased, while the glasses removal rate score and surgical satisfaction score were significantly increased in the observation group (P<0.05).Age >65 years old, illiteracy, good open-eye distant vision ≥0.1(LogMAR), and implantation of aspheric unifocal intraocular lens were the factors affecting the quality of life of cataract patients. Conclusion: Compared with aspheric unifocal intraocular lens, Oculentis regional refracting multifocus intraocular lens can provide good overall vision in the short term after operation, and the postoperative contrast sensitivity, visual quality, quality of life, glasses removal rate and satisfaction of cataract patients are significantly improved, which is worthy of clinical promotion.]]> 2020/9/4 16:47:17 0.05). At 1d, 7d, 1m, and 3m postoperatively, the intraocular pressure of experimental group were significantly lower than that of control group (P <0.05), but at 6m, 12m postoperatively, there was no significant difference on intraocular pressure between the two groups ( P> 0.05). At 6 months postoperatively, the vision improvement of experimental group was significantly better than that of control group (P <0.05). The total postoperative complication rate of experimental group and control group were27.27%(18/66) and 37.10%(23/62), respectively. There was no significant difference on the total postoperative complication rate between the two groups (P> 0.05). Conclusion: Conbercept intravitreal injection combined with Ex-PRESS glaucoma drainage device implantation for patients with NVG has significant effects, can effectively reduce intraocular pressure, improve vision, and with good security. It is worthy of clinical application.]]> 2020/9/3 15:50:01 2020/9/3 13:47:02 2020/9/3 10:56:31 2020/9/3 10:46:41 0.05）．The prevalence of myopia in 5 to 11 years old children was 46.3％in boys and 53．7％in girls．Among myopic children aged from 5 to 11 years old,40.5% children had advanced bone age,40.2% children had normal bone age difference, and 19.2% children had backward bone age, the difference was statistically significant（X2 =21.576，P<0.05）. Among the children with advanced bone age, the proportion of girls was much higher than that of boys, and the difference between bone age difference and gender was statistically significant （X2 =72.566，P<0.05）.Conclusions There was an association between the age and Height、weight、BMI、 SE、axis length．There are a lot of myopic children with advanced bone age, especially girls.]]> 2020/9/3 10:15:40 2020/9/2 10:44:44 2020/9/2 10:33:14 2020/9/2 10:05:15 2020/9/2 9:53:23 2020/8/31 18:23:21 2020/8/31 17:39:28 2020/8/31 17:02:51 2020/8/31 11:40:09 2020/8/28 17:33:09 2020/8/28 9:47:57 2020/8/27 14:34:07 0.05); (2) There was no statistical difference between the treatment group and the control group in terms of efficacy: the total effective rate was about 94.92% in the treatment group and 96.61% in the control group, and there was no statistical difference between the two groups (P > 0.05). Conclusion (1) Ultrasonic atomization combined with meibomian gland massage can improve the subjective symptoms and objective indexes of MGD related dry eyes. (2) Compared with the modern medical treatment, the therapeutic effect of this method is basically the same, safe and effective, but it is more convenient and economic, which is worth popularizing in clinical application.]]> 2020/8/25 14:53:33 2 quadrants". The clinical characteristics of these cases and the related conditions after intravitreal injection of ranibizumab were observed by the quadrant method. Results: 32 cases of retinopathy of 62 eyes of premature infants included in the study were distributed in only 2 eyes in 1 quadrant before surgery, and the efficiency of a single injection was 100%; distributed in 2 quadrants, a total of 25 eyes, a single injection The effective rate was 100%; a total of 35 eyes with a distribution> 2 quadrants had a single injection rate of 74.29% and a recurrence rate of 25.71%. Conclusion: The main lesions in most cases are distributed in 2 quadrants (supertemporal subtemporal), and the more the number of quadrants accumulated for the major lesions, the more serious the condition, and the recurrence rate of intravitreal ranibizumab treatment. high. If quadrant screening is used in clinical work, screening time can be significantly shortened, efficiency can be improved, and light stimulation for preterm infants can be reduced.]]> 2020/8/24 10:53:51 0.05). There was a statistically significant difference in corneal endothelial cell density(2 159.84±245.20/mm2 in the group A and 2 019.68±203.97/mm2 in the group B) between the two groups after 3mo of operation(t=2.289,P<0.05).There was no significant difference in corneal astigmatism between the two groups (group A 1.57D±0.74D and group B 1.39D±0.71D) after 3mo of operation (t=0.930,P>0.05).Conclusion: MSICS with long incision, long tunnel, thick scleral flap and trapezoidal internal incision has less damage, quicker recovery and better effect on patients with hard nucleus aged cataract than short incision, short tunnel and linear internal incision]]> 2020/8/10 10:22:20 2020/8/10 10:04:03 2020/8/10 9:46:26 0.05). The LogMAR of naked eyes of both groups decreased significantly at 1 day, 1week and 1 month after surgery (P<0.05), and the degree of astigmatism increased (P<0.05). The naked vision and astigmatism of the micro-incision group were better than those of the standard incision group at 1 day and 1 week after surgery (P<0.05). Endothelial cell density was significantly decreased at 1 day, 1week and 1 month after surgery (P<0.05). The coefficient of variation of corneal endothelial cells and the thickness of central cornea increased (P<0.05). There was no significant difference between the standard incision group and the micro-incision group at each time point (P>0.05). There were no severe complications in either group. There was one patient with transient high intraocular pressure in the standard incision group, and the intraocular pressure returned to normal after drug treatment. Conclusion: Both coaxial micro-incision phacoemulsification and standard small incision surgery have certain effects on the morphology and function of endothelial cells. Besides, there is no significant difference between them. However, coaxial micro-incision phacoemulsification can minimize the surgical incision and reduce the degree of surgically induced astigmatism, and patients can recover quickly after surgery. It is a relatively safer surgical procedure.]]> 2020/8/6 16:01:21 2020/8/6 15:20:18 2020/8/6 14:08:58 2020/8/5 16:08:47 2020/8/5 10:53:58 0.05).The degree of eyeball protrusion was 13-16mm, with an average of 14.4±0.8mm, and the degree of corrected eyeball protrusion was 2-4mm, with an average of 2.4mm (q=10.737，P<0.01).The degree of eyeball protrusion at 6 months after surgery was 13-15.5mm, with an average of 14.5±0.6mm, showing no significant difference from 1 month after surgery (q=0.624，P=0.173).1 month after surgery, the strabismus was 2-10△, with an average of 6.7±2.3△, all of which were under correction (q= 18.068，P<0.01). Before surgery, all the patients had diplopia at the first sight, and the first diplopia disappeared one month after surgery.All patients showed significant improvement in compensatory head position.The strabismus (undercorrection) of the patients at 6 months after surgery was 0-7△, with an average of 3.4±1.2△, and the difference was statistically significant compared with 1 month after surgery (q= 5.385，P=0.015).The patient had no diplopia at the first and lower transitory position.The mean intraocular pressure after surgery (17.12 ± 1.89)mmHg was lower than that before surgery, and the difference between preoperative and postoperative intraocular pressure was statistically significant (q=4.258，P=0.018）.The mean intraocular pressure at 6 months after surgery was 17.53± 1.67mmhg, with no significant difference from 1 month after surgery(q=0.729，P=0.154). Conclusion：Orbital fat resection can improve the protrusion of the eyeball, but has no significant influence on the surgical design and effect of restrictive strabismus.It is a kind of controllable operation scheme to treat the limited strabismus with exophthalmos of thyroid associated ophthalmopathy with rectus muscle release and recession combined with orbital fat resection.]]> 2020/8/4 14:44:49 0.05). The corneal edema and thickness change were observed in group B, C and D, and there were significant differences (P<0.05) compared with group A. CONCLUSION: Dexamethasone combined with hypertonic glucose solution has a good protective effect on rabbit corneal endothelial cells. And early application can effectively prevent rabbit corneal edema and this method can also prevent the progression of corneal endothelial decompensation.]]> 2020/8/4 14:42:06 2020/8/4 9:20:23 2020/8/3 11:10:01 2020/8/3 10:29:44 2020/8/3 10:25:45 0.05); ?CONCLUSION: After ICL V4c implantation, the anterior chamber angle parameters in the horizontal direction of 1d, 1mo, 3mo 6mo and 1a were smaller than those before ICL V4c implantation, and tended to be stable after 3mo.]]> 2020/8/3 10:04:43 2020/7/30 11:47:40 0.05) . Results of the study using frequency domain OCT (SD-OCT) showed that the thickness of macular fovea and the thickness of each zone in amblyopic eyes were greater than those of the contralateral non-amblyopic eyes, except for the central area of the macular fovea with diameter 1mm and the outer ring area below 3 to 6mm. In addition, the rest of the comparisons were different (P <0.05); the average thickness of RNFL and the thickness of each zone of the nose in amblyopic eyes were larger than those of the contralateral non-amblyopic eyes (P <0.05). CONCLUSIONS: Thickness of the macular area and RNFL of the amblyopic eye of monocular anisometropic amblyopia is higher than that of the contralateral non-amblyopic eye, and amblyopia mainly causes the thickness of the macular fovea to increase within 1 mm diameter.]]> 2020/7/30 11:29:44 2020/7/30 10:30:55 2020/7/28 9:50:17 2020/7/28 9:28:32 2020/7/27 11:38:20 2020/7/27 11:27:29 2020/7/27 10:50:11 2020/7/27 10:40:04 2020/7/23 9:53:13 2020/7/22 15:07:31 0.05).After treatment, all ocular parameters and distribution in the experimental group were significantly better than those in the conventional group (P<0.05).Compared with before treatment, IFN-γ level was decreased and IL-4 level was increased in both groups after treatment, with statistically significant difference (P<0.05). After treatment, IFN-γ level in the experimental group was significantly lower than that in the conventional group, and IL-4 level was significantly higher than that in the conventional group (P<0.05).Compared with the conventional group, the experimental group had a high total effective rate, a short cure time, a low recurrence rate within 1 year and a long recurrence interval, with statistically significant differences (P<0.05).Conclusion: CMV positive PSS patients had different ocular clinical points from negative patients, with higher intraocular pressure and more damage to corneal endothelial cells. Local points of 2% ganciclovir eye drops can effectively control the development of intraocular pressure and inflammation by resisting CMV infection, with significant clinical efficacy and short-term not easy to relapse.]]> 2020/7/10 14:11:31 2020/7/9 16:57:32 0.05). The corneal epithelial cells in group A was set as normal morphology, while the corneal epithelial cells in group B and group C showed filamentous separation of surface cells to varying degrees, and the number of conjunctival goblet cells was decreased. The lacrimal gland of group C was obviously atrophic. In conjunctival and corneal tissues, the expression of EGF, TNF-α and IL-6 were significantly increased in group B and group C, which was statistically significant compared with group A (P<0.05). The expression of EGF and TNF-α didn’t altered significantly between group B and group C (P>0.05), however, the expression of IL-6 in group B was much higher than that in group C (P<0.05). CONCLUSION: In this study, we proved that both lacrimal gland extirpation and lacrimal gland injection botulinum toxin A could construct a stable aqueous tear deficiency dry eye rat model. The appropriate animal model should be selected according to the experimental design and research purpose.]]> 2020/7/9 15:41:16 2020/7/8 16:49:52 2020/7/8 11:33:17 2020/7/7 16:21:52 0.05). The 95% consistent line (LoA) of offset value and offset orientation in the right eyes, left eyes and both eyes between the two instruments were -0.11~0.19mm and -157.01~135.35, -0.12~0.18mm and -150.16~158.22 °, -0.12~0.18mm and -154.30~147.10 °, respectively. Conclusion The pupillary offset measured by the Pentacam was smaller than that measured by the Keratron, but the difference was within the clinically acceptable range. The accurate pupillary offset can be obtained, and be the mutual reference, correction and supplement in the both instruments.]]> 2020/7/6 10:49:48 2020/7/3 16:06:50 2020/7/3 9:42:58 2020/7/2 17:22:25 2020/7/2 10:31:48 0.05). After treatment, the intraocular pressure in group A was lower than that in group B (P < 0.05). 6 months after treatment, the visual acuity, intraocular pressure control rate and neovascularization in group A were better than those in group B (P < 0.05). There was no significant difference in the incidence of complications between the two groups (P > 0.05). Conclusion It is safe and effective to treat NVG with intravitreal ranibizumab injection combined with vitrectomy,PRP and trabeculectomy, which can control intraocular pressure steadily and improve visual acuity of some patients.]]> 2020/7/1 15:19:11 2020/7/1 11:01:24 2020/6/30 14:15:47 2020/6/30 14:02:29 2020/6/30 11:00:17 2020/6/30 8:57:51 2020/6/29 9:46:01 0.05). The FA values of bilateral optic nerve and optic radiation decreased compared with the normal control group, and the difference was statistically significant (both P <0.05). There was no significant difference of optic chiasma, bilateral visual tract’s FA value, and bilateral visual pathway ADC value between the two groups (all P> 0.05). Conclusion 3D-OCT can obtain the thickness of CP-RNFL and the parameters of optic disc, DTI can reconstruct the intracranial visual pathway and can detect the microscopic changes of optic nerve, optic chiasma, optic tract, and optic radiation at early stage. Combining 3D-OCT and DTI technology can effectively understand the microscopic changes of the visual pathway and provide new models for clinical research of Ocular Hypertension patients.]]> 2020/6/29 9:25:25 2020/6/28 11:42:04 2020/6/28 11:05:41 2020/6/28 9:42:28 2020/6/23 10:56:32 2020/6/18 14:46:43 2020/6/12 8:40:31 2020/6/11 13:54:41 1, P<0.05). All of the above risk factors will significantly reduce the corrected vision of DR patients. The corneal thickness of patients with DR (550.82±34.73μm) was greater than those without DR (542.37±33.32μm) (P<0.05). The anterior chamber depth of patients with diabetes over 10 years (2.49±0.43mm) was less than those with diabetes less than 10 years (2.68±0.40mm) (P<0.05). Conclusions The course of diabetes, diabetic nephropathy and insulin use were the risk factors for DR. Patients with long duration of diabetes had a shallower anterior chamber depth.]]> 2020/6/11 9:47:18 2020/6/10 11:48:59 2020/6/10 9:48:38 2020/6/9 9:57:46 2020/6/8 14:45:22 0.05),and the mean corneal curvature measured by the two methods had no statistically significant differences (P > 0.05).There were no statistically significant difference of the mean corneal curvature measured by the two methods in the three axial eye groups (P > 0.05) and in the same axial eye group (P > 0.05).There were no statistical difference in the absolute error of the two IOL measurement formulas in the three eye axis groups (P > 0.05).The absolute error calculated by SRK-T formula for the short and the middle eye axis groups were smaller, while it calculated by Haigis formula for long eye axis group was smaller.Conclusion In our department,there are no statistical difference in the eye biometrics of han, yi and hani nationality. Corneal curvature measured by corneal topography and corneal keratometer have no significant difference.SRK-T and Haigis formula both have high predictive value for IOL degree, SRK-T formula has smaller predictive error for patients which with short and middle eye axis, and Haigis formula has better predictive value for the long ones.]]> 2020/6/8 11:30:38 2020/6/8 11:20:08 2020/6/8 10:37:42 2020/6/5 10:30:12 2020/6/5 10:03:43 2020/6/5 9:59:51 2020/6/4 10:33:41 2020/6/4 10:13:47 2020/6/2 16:20:58 2020/6/1 14:57:13 2020/6/1 11:54:12 2020/6/1 10:41:37 2020/5/29 17:06:27 2020/5/29 15:02:30 2020/5/29 10:19:48 2020/5/28 10:27:52 2020/5/28 9:55:56 2020/5/28 9:28:03 2020/5/14 15:22:20 0.05) in 3rd, 7th day between the two groups. There was no significant difference (P > 0.05) in the flash of anterior chamber of 1st, 3rd, 7th day and 1 month between the two groups. There was no significant difference (P > 0.05) in the changes of vision and the formation of filtering blebs between the two groups in 3rd month. Conclusion: Combined trabeculectomy and air filtration in the anterior chamber for chronic primary angle closure glaucoma can reduce the incidence of shallow anterior chamber, malignant glaucoma and unplanned reoperation, not aggravate the inflammatory reaction in the anterior chamber, safely retain the residual visual function of patients, shorten the length of stay in hospital and the total cost of hospitalization, and have no effect on the formation of intraocular pressure, vision and filtering bleb Obvious influence.]]> 2020/5/13 17:17:42 2020/5/13 9:48:55 2020/5/13 9:25:34 2020/5/12 16:59:05 0.05). Conclusion The accommodation function of anisometropic children in correcting anisometropia by monocular orthokeratology was significantly improved compared with that before wearing the lens and was consistent with the contralateral eyes without lens group. The refractive state of the group wearing orthokeratology lens was more stable, and the contralateral eyes without lens gradually showed mild myopia refractive state, but the accommodation did not change significantly.]]> 2020/5/12 16:47:37 2020/5/11 11:15:46 2020/5/11 10:44:11 2020/5/11 10:24:57 2020/5/9 11:42:40 0.05). Of the 30 eyes, 28 eyes underwent 1 laser ablation treatment, and 2 eyes underwent 2 laser ablation treatment. The average number of treatments was 1.06. After treatment, the autofluorescence of angiography shows that the vitreous opacity is significantly reduced or disappeared. and the difference between the two groups was statistically significant (P<0.01). No complications occurred during or after surgery. CONCLUSION: A/B ultrasound combined with autofluorescence confirmed that YAG laser is safe and effective in the treatment of physiological vitreous floaters. KEYWORDS：Nd：YAG laser; physiological vitreous floaters; A/B ultrasound; autofluorescence of angiography; Imege-J software]]> 2020/5/9 10:25:03 0.05).Significant difference was observed among other BCVA(P<0.05). 2.Negative accommodation: There were no significant difference between preoperative and postoperative negative accommodation(P>0.05). 3.Positive accommodation: Compared with preoperative date, the 1 day,1 week,1 mouth postoperative positive accommodation were no significantly different(P>0.05),but the 3 mouths,6 mouths,1 year postoperative positive accommodation were significantly different(P<0.05). 4.Accommodative acuity: There were no significant difference between preoperative and postoperative accommodative acuity(P>0.05). 5.Near point of convergence: Compared with preoperative date, the 1day,1 week postoperative near point of convergence were significantly different(P<0.05),the 6 mouths,1 year were no significantly different(P>0.05). Significant difference was observed among other near point of convergence(P<0.05). 6.Convergence scope: Compared with preoperative date, the 1day,1 week,1 mouth postoperative convergence scope were no significantly different(P>0.05),the 3 mouths,6 mouths,1 year were significantly different(P<0.05). 7.AC/A: Compared with preoperative date, the 1day,1 week postoperative date decreased significantly(P<0.05).There was no significantly difference between the 6 mouths and 1 year postoperative date(P>0.05). Significant difference was observed among other AC/A(P<0.05). 8.Visual stereoacuity: Compared with preoperative date, the 1day,1 week,1 mouth postoperative visual steroacuity were no significantly different(P>0.05),the 3 mouths,6 mouths,1 year were significantly different(P<0.05). Conclusion The BCVA of patients of cataract with high myopia which underwent standard femtosecond laser assisted phacoemulsification and intraocular lens implantation improved obviously and early, but the visual function improved slowly. Having an adequate understanding of the contents and significance of visual function was helpful to the improvement of cataract surgery techniques and postoperative visual acuity.]]> 2020/5/8 13:59:07 2020/5/8 10:41:03 2020/5/7 11:34:06 2020/5/6 10:30:06 2020/5/6 9:41:41 2020/4/30 10:45:15 2020/4/30 10:18:24 2020/4/29 15:26:50 2020/4/29 9:53:57 2020/4/28 14:29:09 0.05).In patients with severe chronic sinusitis combined with chronic dacryocystitis, the efficiency of phased operations was higher than that of the simultaneous surgery(P<0.05), and the complications were lower than that of the simultaneous surgery(P< 0.05）.Conclusion: According to Lund-Mackay score,patients with mild to moderate chronic sinusitis and chronic dacryocystitis are advised to undergo simultaneous surgery, while patients with severe rhinosinusitis are advised to undergo phased surgery.]]> 2020/4/28 10:28:22 2020/4/28 9:23:38 65 years old). The majority of patients (79, 75.2%) came from townships. The nature of IFB was mainly metals (62 cases, 59.0%). The entrance of IFB of 78 cases (74.3%) located at Zone I of the eye. There were 17 patients with BCVA≥0.1 before surgery, 88 patients with BCVA<0.1. And 43 patients gained BCVA≥0.1 after operation, and 62 patients with BCVA<0.1. Postoperative BCVA was significantly improved compared with preoperative BCVA (P<0.05). Retinal detachment, endophthalmitis, IFB size and retained position were found negatively correlated with final BCVA levels (all P<0.05). Other parameters, like age, gender, entrance site, hyphema, traumatic cataract, vitreous hemorrhage, and time to visit were not correlated with outcomes (P>0.05). Conclusion: PPV for treatment of IFB can achieve a better outcome. The poor prognosis of visual acuity is related to retinal detachment, endophthalmitis, and the position and size of IFB. KEY WORD: intraocular foreign body; 25G minimally invasive vitrectomy; clinical observation; visual prognosis]]> 2020/4/20 9:32:24 0.05). Compared with that those of before intervention, in both of the 2 groups, after treatment strabismus decreased, naked vision, best corrected vision and FBUT increased, diopter deepened, and the proportion of patients with excellent visual quality increased; And the after treatment naked visual acuity, best corrected visual acuity, FBUT, diopter and visual quality in the study group were better than those in the control group (P < 0. 05). There was no significant difference in therate of adverse reactions and complications such as orbital and orbital pain, eye distention, headache, blepharoconjunctival vascular congestion between the two groups (P > 0.05). Conclusion: On the basis of triangular prism orthophotic training, the wearing of orthopaedic keratoplasty lenses can improve the tear film, refraction and visual quality of intermittent exotropia, and its safety is good, which is worthy of clinical application.]]> 2020/4/17 14:09:42 2020/4/17 9:08:02 2020/4/15 10:10:37 2020/4/15 9:48:55 0.05).Theaverage operation time of group A was lower than that of group B (73.19±22.78minvs 91±31.36min,P<0.05),There were no significant difference in thenumber of intraoperative bleeding,electrocoagulation,iatrogenic retinal tears, omental incision eyes, silicone oil-filled eyesbetween the two groups (P>0.05).One week after PPV,The incidence of high intraocular pressure in group A was lower than that in group B (group A :4 eyes vs group B:9eyes,P<0.05).6-month post-operative follow-up,No recurrent vitreous hemorrhage occurredin either group, there were no significant difference in the incidence of secondary glaucoma and recurrent retinal detachment between the two groups (P>0.05). Conclusion:PDR patients who received IVC2-3days prior to PPVhad shorter operation timethan patients who received IVC 7-8days prior to PPV. Both groups can improve postoperative visual acuity, and the long-term clinical efficacy and safety are basically the same. Key words: proliferative diabetic retinopathy; vitrectomy;Conbercept; timing]]> 2020/4/15 9:23:00 0.05). CONCLUSION: Intravitreal injections of Conbercept can effectively reduce the subretinal fluid and retinal fluid in patients with wet age-related macular degeneration, and improve the patient's visual acuity. Patients with the integrity of the outer layer of the retina (especially the ellipsoidal zone) and SRF responded well after treatment, while patients with IRF responded poorly after treatment.]]> 2020/4/14 16:59:00 2020/4/14 15:13:55 0.05)；a positive correlation between axial length and anterior chamber depth (r= 0.433, P < 0.05), a negative correlation between axial length and corneal curvature (K1, K2, Km) (P < 0.05)；a negative correlation between total higher-order aberrations and diopter （r=-0.189，p＜0.05），With the increase of myopia degree, the total higher-order aberrations increased, which was negatively correlated with the axial length（r=-0.228，p＜0.05）. There was no correlation between the higher-order aberrations and the sphericity (P > 0.05), but with the cylinderc, equivalent spherical and corneal curvature. RMS5 was positively correlated with age (r = -0.218, P < 0.05), Z40 was positively correlated with the corneal curvature (K1, K2, Km) (P < 0.05), and no higher-order aberrations was found The difference was related to CCT, ACD and ACA. Conclusion With the change of diopter and axial length the eye, the corneal curvature changes. With the increase of the axial length of the eye, the corneal curvature tends to flatten. Most of the high-order aberrations are related to the corneal curvature. The total high-order aberrations increase with the increase of the degree of myopia, and are negatively related to the axial length the eye. The increase of the axial length of the eye may be a compensatory way to reduce the high-order aberrations and promote the development of myopia.]]> 2020/4/14 11:06:07 2020/4/14 9:27:48 2020/4/13 15:32:22 2020/4/13 9:50:18 2020/4/10 9:34:19 2020/4/9 17:23:22 0.9 have high diagnostic value. There was no statistical difference between among the parameters (P>0.05). The diagnostic efficacy of inside disc capillary density (%) and inside vascular density (%) is significantly lower than that of other parameters AUC of 0.85 and 0.88 respectively, and the paired comparison P<0.05 has statistical difference. Conclusion:Compared with the positive control group, the vascular density in POAG group decreased significantly and became more serious with the progress of the disease. Vascular density in optic disc region is a good indicator for evaluating structural damage in POAG patients, and is of great significance in diagnosis and follow-up of POAG. However, the diagnostic efficiency of inside disc vascular density and capillary density for POAG is obviously lower than other vascular parameters .]]> 2020/4/9 17:04:13 0.05). At 7 and 30 days postoperatively, the OSDI score and FL score of the study group were significantly lower than the control group, and the BUT and SIt of the study group were significantly higher than the control group, the difference was statistically significant (p < 0.05). Conclusion: Application of artificial tears before phacoemulsification combined with intraocular lens implantation can significantly relieve early dry eye symptoms, restore tear film function, and prevent postoperative dry eye aggravation. Key words: preoperative; artificial tears; dry eye syndrome; cataract; phacoemulsification]]> 2020/4/8 9:43:01 2020/4/7 14:54:06 2020/4/7 10:36:57 2020/4/7 9:52:39 2020/4/7 9:35:23 2020/4/3 11:45:27 2020/4/3 11:02:33 2020/4/1 16:11:32 2020/4/1 11:47:06 2020/4/1 10:23:19 2020/4/1 9:40:25 2020/3/19 9:32:11 2020/3/18 14:01:19 2020/3/18 9:31:55 2020/3/17 9:59:15 2020/3/17 9:40:24 2020/3/16 13:53:02 0.05). However, after 3 months, the OSI value of the FS-LASIK group was higher than the SMART group (0.88 ± 0.28 vs 0.70 ± 0.27, P <0.001), whereas the SR was lower than SMART group (0.21 ± 0.05 vs 0.24 ± 0.05, P = 0.002). Conclusion: Both FS-LASIK and SMART caused an increase in the intraocular scattering index and a decrease in objective visual quality. However, the visual quality of the SMART group was generally better than that of the FS-LASIK group, and long-term visual quality was more dominant.]]> 2020/3/16 11:15:22 0.05). However, SE and axial length showed trendency to greater myopic shift in the Zhu Jingfang groupand the saline group (P<0.05). The effect began to appear on the first day after administration, achieved the maximum effect after three days, and faded completely until seven days. On the first day after administration, the diopter and the axial length in ranibizumab group showed the lowest among three groups (P<0.05), and choroid thickness showed the thickest among three groups (P<0.05).. At 3 days after administration, the diopter and the axial length in the saline group showed the lowest among three groups, and choroid thickness showed the thickest among three groups (P<0.05). There was no significant difference in the parameters among the three groups at 1 week after administration (P>0.05). Conclusion There is a temperary choroidal thickening of the form deprivation myopia recovery period .Theranibizumab inhibited the thickening of the choroid in the whole recovery period of form deprivation myopia, zhuJingfang slight inhibited the thickening at 3 days,and the all change persisted only for a week.]]> 2020/3/13 16:38:21 2020/3/6 9:04:03 2020/3/5 11:47:02 0.05), and there was significant difference in the incidence of side-effect between young men and women (2=7.856, P = 0.005 < 0.01).There was significant difference in the incidence of side-effect in different fundus diseases after retinal laser photocoagulation(F ≤ 14.167, P ≤ 0.019). There was significant difference in the side-effect between PDR and retinal detachment ((2=5.211, P=0.022＜0.05). There was no significant difference in the other diseases. difference. Conclusions The probability and severity of side-effect in the treatment of different fundus diseases by retinal laser photocoagulation is different.We should know the patient's medical history and mental state in detail before operation, prepare for patients with high risk factors and possible serious reactions, so as to ensure the life safety of patients]]> 2020/3/5 9:27:26 0.05). There was no difference in preoperative SIt between Ec group and Ey group (P>0.05). Compared with Ec group, Ey group had 1mo (4.12?1.08) and 3mo (9.43?1.29) postoperatively. The increase of SIt value was more significant (P<0.05). There was no difference in preoperative TBUT between Ec group and Ey group (P>0.05). Compared with Ec group, 1mo (5.78?1.17), 3mo after operation. (7.15?1.81) The TBUT value of Ey group was significantly increased (P<0.05). The preoperative CFS scores of Ec group and Ey group were compared (P>0.05). Compared with Ec group, Ey group was 1mo after operation (3.12?1.25). 3, (0.49 ? 0.21) CFS value decreased (P<0.05); Ec group, Ey group eye surface temperature were (33.78 ? 1.32, 33.84 ? 1.51) ? C, there was no significant difference between the groups (P > 0.05), the dry eye syndrome score was significantly lower in the Ey group than in the Ec group (P<0.05), and the dry eye symptoms in the Ey group were milder. Conclusion: Autologous conjunctival flap transplantation is superior to simple tendon resection, which can promote the recovery of tear film stability in patients with pterygium, and the dry eye symptoms of patients are significantly improved.]]> 2020/3/2 20:42:07 2020/2/28 15:17:39 0.05). The BCVA and CMT in all groups were improved at different time after surgery (P<0.05). The BCVA and CMT in group D were better than those in group A and group B (P<0.05). The BCVA and CMT in group D were better than those in group C at 1 week, 1 month and 3 months after surgery (P<0.05). ②There was no significant difference in intraocular pressure among groups at different time points (P>0.05). ③The laser energy, number of light spots, laser energy density and frequency of laser treatment in group C and group D were lower/smaller than those in group A (P<0.05). The laser energy, number of light spots and laser energy density in group D were lower/smaller than those in group C (P<0.05). The frequencies of injection in group C and group D were fewer than that in group B (P<0.05). ④There was no significant difference in the incidence of complications among the four groups (P>0.05). Conclusion: The curative effect of delayed laser photocoagulation after intravitreal injection of anti-VEGF drug is better than simple photocoagulation, simple intravitreal injection or delayed intravitreal injection after laser photocoagulation in the treatment of DR. It can improve the BCVA, relieve macular edema, reduce laser energy, frequency of laser treatment and injection frequency of anti-V-EGF drug, with safety.]]> 2020/2/28 15:09:45 2020/2/28 9:16:52 0.05). The latency of P1, N1 wave of ring 1 and ring 2 were significantly decresed from baseline, while the amplitude density of P1 wave was increased (P<0.05). Pearson correlation analysis shows that age, baseline BCVA, VLD, VPD, FAZ were significantly correlated with changes in visual acuity before and after treatment (P<0.05). Conclusion In patients with BRVO-ME, ranibizumab therapy can reduce CMT, improve BCVA and improve the structure and function of macular area. Age, BCVA before treatment and microstructure parameters of macular area can be used as predictors of vision improvement. Keywords branch retinal vein occlusion(BRVO), Anti-VEGF therapy, optical coherence tomography angiography(OCTA), Multifocal electroretinogram (mf-ERG).]]> 2020/2/25 17:10:42 2020/2/25 17:09:39 2020/2/24 15:21:25 0.05). Blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte aggregation index were significantly lower than those before treatment and lower than those in control group (P<0.05), while the levels of erythrocyte deformability index was significantly higher than that before treatment and higher than that in control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (3.22% VS. 6.45%) (P>0.05). Conclusion Compassip can effectively improve the visual acuity of patients with PCV, alleviate the clinical symptoms such as macular edema, and it has high safety, no effect on intraocular pressure, so it has high clinical popularization value.]]> 2020/2/21 18:05:29 2020/2/21 10:55:10 2020/2/19 11:42:05 2020/2/18 14:43:58 2020/2/18 14:36:01 0.05). Conclusions: Using MCI in SSB operation could shorten the operation time and significantly reduced postoperative pain and discomfort level.]]> 2020/2/17 9:25:36 2020/2/17 9:12:14 2020/2/14 18:51:30 2020/2/14 15:31:31 2020/2/14 13:38:15 0.05). Cost-effectiveness analysis showed that the cost-effectiveness ratio (C/E) of SHSI group was 13.57, which was much lower than that of En-DCR group (121.50). Conclusion Endoscopic SHSI and En-DCR are both effective surgical methods for NLDO. SHSI has more clinical value because of its relatively lower difficulty and obvious cost-benefit advantages.]]> 2020/2/14 13:37:24 0.05). Compared with CON group, the number of retinal ganglion cells in group D and CON group decreased, with statistically significant difference (P<0.01). Retinal ganglion cells were slightly reduced in N group, with no statistically significant difference (P>0.05). Compared with group N, retinal ganglion cells decreased in group D, and the difference was statistically significant (P<0.01). The mean optical density of PEDF in retinae of rats showed that compared with CON group, the expression of PEDF in group D was decreased, and the difference was statistically significant (P<0.01). PEDF expression was slightly decreased in N group, and the difference was not statistically significant (P>0.05). Compared with group N, the expression of PEDF decreased in group D, and the difference was statistically significant (P<0.01). Conclusion: The protective effect of antioxidant NAC on retinal tissue in early diabetic rats may be due to the upregulation of PEDF levels in the retina.]]> 2020/2/14 12:34:54 2020/2/12 16:48:04 2020/2/12 16:47:05 2020/2/12 15:43:20 2020/2/12 10:44:50 2020/2/11 17:00:21 2020/2/11 16:59:08 2020/2/10 16:39:08 2020/2/10 9:48:39 0.050). Conclusion Qiming granule can alleviate the degree of laser photocoagulation damage to the retina, promote the rapid repair of laser damage, and reduce diabetic macular edema. It is worthy of popularization and application in the clinic.]]> 2020/2/7 10:08:12 2020/2/6 18:31:51 2020/2/6 10:47:18 2020/2/6 9:46:27 2020/2/6 9:14:23 2020/2/6 9:12:16 2020/2/3 15:21:33 2020/2/2 17:07:58 2020/1/21 11:12:15 2020/1/21 10:28:34 2020/1/7 10:24:10 2020/1/6 15:40:01 2020/1/6 10:47:51 2020/1/6 10:19:14 2020/1/4 13:48:31 0.05). Before treatment, retinal fibrosis accounted for 26.09% (6/23) and increased to 39.13% (9/23) one month after treatment. After treatment, the area of CFT, PMT and CNV decreased significantly (P < 0.05). Conclusion Conbercept is effective in the treatment of wAMD. OCT can noninvasively evaluate the changes of macular retinal structure after the treatment of conbercept, which provides convenience for clinical workers.]]> 2020/1/4 9:06:31 0.05).No statistically significant difference was found in anterior corneal curvature of the group A and B at postoperation 1wk,1mo and 3 mo(P>0.05).One week postoperation,the anterior corneal astigmatism of the group A was statistically significant from that of one month postoperation(P<0.05),there were no significant differences at 1mo,3mo after operation (P>0.05). No statistically significant difference was found in anterior corneal astigmatism of the group B at postoperation 1wk,1mo and 3mo(P>0.05). CONCLUSION:Whether to correct low and high astigmatism, no significant changes of posterior corneal curvature and anterior chamber depth was found after Femtosecond Laser-Assisted LASIK for correct myopic astigmatism.The anterior corneal curvature of low and high astigmatism group was stable from 1wk to 1mo.The astigmatism of high astigmatism group was stable from 1mo to 3mo.The astigmatism of low astigmatism group was stable from 1wk to 3mo.]]> 2020/1/3 15:29:35 2020/1/3 15:10:16 2020/1/2 15:25:56 0.3 in the combined group was higher than that in the glucocorticoid group, and the incidence of patients with visual acuity of < 0.02, 0.02-0.05 was lower than that in the glucocorticoid group (P<0.05). The effective rate of combined group was higher than that of glucocorticoid group, and the recurrence rate of combined group was lower than that of glucocorticoid group (P<0.05).Conclusion:Cyclosporin A combined with hormone treatment of Mooren's corneal ulcer has significant effect, can reduce inflammation, improve the quality of life of patients, improve their clinical symptoms, reduce recurrence, and promote visual recovery of patients.]]> 2020/1/2 15:13:27 2020/1/2 10:09:28 2019/12/31 11:16:18 2019/12/31 11:02:48 2019/12/31 10:37:41 2019/12/31 10:28:06 2019/12/30 10:00:24 0.05).Conclusion:Puerarin combined with lecithin complex iodine tablets has a significant effect in the treatment of patients with fundus hemorrhage. It can improve the related indexes of plasma viscosity, hemostasis effect is good, and improve the treatment efficiency.]]> 2019/12/27 17:17:02 0.05）. CONCLUSION：The red-green duochrome test does not affect optometric results.]]> 2019/12/27 15:00:13 2019/12/27 14:13:44 2019/12/27 10:24:16 2019/12/26 9:39:04 2019/12/26 9:01:46 0.05). According to Logistic analysis, TG(OR=4.132), TC(OR=2.194), TG/HDL(OR=2.184) and TC/HDL (OR=2.007) were risk factors for pterygium. CONCLUSIONS: Dyslipidemia is an im-portant factor in the pathogenesis of pterygium. It is very necessary for the patients with pterygium to control the level of blood lipids because it has important clinical significance for the attack and treatment of them.]]> 2019/12/25 16:29:05 2019/12/25 16:13:15 0.05).However, central PCE,ACV and central ACD at 1 week, 1 year and 3 years postoperatively were all decreased (P < 0.01). Except for the anterior peripheral ACD at 3 years after SBK, other peripheral ACD at any time point postoperatively were all decreased (P < 0.01).]]> 2019/12/25 16:03:36 2019/12/25 15:32:16 2019/12/25 13:51:59 2019/12/25 11:53:36 2019/12/25 9:43:36 2019/12/24 16:12:25 2019/12/19 8:50:12 2019/12/18 21:15:01 2019/12/16 11:34:12 2019/12/16 10:54:11 2019/12/16 10:52:52 2019/12/5 10:12:48 0.05).Morphologically,only the 15-days’ tail-suspended mice showed FFA with microvascular dilation and tortuosity.Rhodopsin and cone-opsin were almost normal and no apoptotic-positive signals were detected in the retinas of the three tail-suspended groups. •CONCLUSION:Simulating cephalad shifting of bodily fluids as under microgravity, using short-term tail-suspension can affect rodent ERG and retinal microcirculation; however, the change is reversible with no obvious permanent injury observed in the retinas.]]> 2019/12/5 9:46:43 0.05), and the other differences were significant difference (all P< 0.05). 【Conclusion】Pathophysiological changes in macular retinal thickness and volume occurred in early diabetic patients without significant visual impairment. Using 3D OCT to measure and analyze the thickness and volume of macular retina, to understand the structure and morphological changes of macular retina in early diabetic retinopathy, to provide basis for early diagnosis and treatment of diabetic retinopathy, and to provide help for early prevention and development of diabetic macular edema.]]> 2019/12/5 9:06:42 0.05), but the visual acuity of the control group decreased (P < 0.05). There was no significant difference in temporal RNFL thickness after treatment (P > 0.05). RNFL thickness in other directions and average RNFL thickness were thinner than those before treatment (P < 0.05). After photocoagulation, the changes of MS in the corresponding visual field of temporal nerve fibers were not significantly different from those before photocoagulation (P > 0.05), while the other directions and average MS were lower than those before photocoagulation (P < 0.05). After treatment, there was a weak positive correlation or no correlation between RNFL and the corresponding visual field of RNFL at nasal, nasal superior, temporal superior, temporal, temporal superior, temporal inferior and average RNFL in the photocoagulation group. Conclusions PRP can effectively control the further development of severe NPDR and PDR and maintain the visual acuity of patients, but the damage of PRP to RNFL and visual field can not be ignored.]]> 2019/12/4 13:43:43 2019/12/4 9:42:14 2019/12/3 11:11:48 0.05). There were significant differences in vertical shift and horizontal shift of intraocular lens among the three groups at 1 month and 3 months after surgery (P<0.05), and the vertical shift and horizontal shift of intraocular lens at 1 month and 3 months after surgery in group A were lower than those in groups B and C (P<0.05), and there were no significant differences in vertical shift and horizontal shift between group B and group C (P>0.05). The incidence rate of posterior capsule wrinkle in group A after surgery was obviously higher than that in group B and group C (P<0.05). Conclusion The intraocular stability and safety of Phaco single-piece IOL are better than those of Phaco three-piece IOL, but Phaco three-piece IOL has deeper ACD after surgery and can prevent the forward shift of IOL, and they have their own advantages and disadvantages.]]> 2019/12/3 10:54:33 2019/12/3 10:15:43 2019/12/3 9:36:14 2019/12/2 17:07:42 2019/11/29 15:07:20 2019/11/29 14:52:57 2019/11/29 14:43:05 2019/11/29 14:21:24 2019/11/29 9:23:33 2019/11/27 17:30:32 2019/11/27 16:43:43 2019/11/27 11:12:42 2019/11/27 10:36:15 2019/11/26 10:28:28 2019/11/26 9:52:34 0.05). The visual acuity of both groups after surgery was significantly better than that before surgery (P<0.05). After surgery, visual acuity improvement of study group was better than that of control group (P<0.05), the differences between the two groups were significant. The anterior chamber depth in both groups after surgery was higher than that before surgery, while intraocular pressure was lower than that before surgery, the differences were statistically significant before and after surgery (P<0.05). After surgery, anterior chamber depth of study group was significantly higher than that of control group (P<0.05). There was no significant difference in intraocular pressure between the two groups after treatment (P>0.05). The cell area variation coefficient, hexagonal cell ratio, average cell area and corneal center thickness in control group after surgery were significantly higher than those before surgery (P<0.05), while CECs density was significantly lower than that before surgery (P<0.05). There was no significant difference in CECs related indexes in study group before and after surgery (P>0.05). After surgery, changes levels of CECs related indexes in study group were significantly lower than those in control group (P<0.05). The incidence rates of postoperative complications in study group and control group were 5.08% and 20.37%, respectively (P<0.05). Conclusion: The application of phacoemulsification and intraocular lens implantation in treatment of glaucoma combined with cataract can improve visual acuity and intraocular pressure of patients, maintain structural integrity of CECs, with relatively better safety.]]> 2019/11/25 21:35:38 2019/11/25 21:16:43 2019/11/25 11:52:55 2019/11/25 11:10:06 2019/11/22 14:42:34 2019/11/22 13:09:07 2019/11/22 12:17:03 2019/11/22 11:39:56 2019/11/21 11:00:26 2019/11/21 10:05:52 2019/11/21 10:05:12 2019/11/11 11:23:50 2019/11/8 13:57:21 0.05). Conclusion：Glare degree had no relationship with SE but mid-frequency contrast sensitivity.]]> 2019/11/8 9:10:57 2019/11/7 14:44:39 2019/11/7 14:43:31 2019/11/7 13:57:17 2019/11/6 22:12:08 0.05).In terms of re-examination compliance and persistence on wearing lens,significant difference was observed in educational stage,studying way and parents' education level(P<0.05),,no significant difference was observed in gender,area,family economic status, vision before and after wearing lens and myopia control effect (P>0.05). Multivariate Logistic regression analysis showed that educational stage,studying way and parents' education level were correlated with re-examination compliance and persistence on wearing lens(P>0.05). •Conclusions Compliance of orthokeratology lens in the treatment of teenagers' and children's myopia in Dongguan was correlated with educational stage,studying way and parents' education level, to improve the compliance of orthokeratology lens in the treatment of teenagers' and children's myopia, Standardize fitting,standardize care,normative propaganda and education, review on time and regular return visits were important.]]> 2019/11/6 21:14:18 0.05). While, no statistically differences were observed in the Schirmer I test comparing the two groups(P>0.05). CONCLUSION: OK wearing may increase the OSDI and the Oxford scores mildly, and decrease the stability of tear film. Special attention must be paid to the OK wearers with baseline and follow-up ocular surface, tear film condition, and discomfort symptoms.]]> 2019/11/6 16:41:00 ? 6D), 56 eyes in the high myopia group (? 6D ≥ SE > ? 9D), and 25 eyes in the ultra-high myopia group (SE > ? 9D).The mean retinal nerve fiber layer thickness of the optic disc and the nerve fiber layer thickness of the four quadrants were analyzed, as well as the peripapillary atrophy area (PPA), optic disc ovality index (OI), and horizontal optic disc tilt (HOT). Results: The thickness of nerve fiber layer in each quadrant was significantly different among the four groups (P < 0.01). The mean thickness of nerve fiber layer, the thickness of superior nerve fiber layer and the thickness of nasal nerve fiber layer were significantly higher in the control group than in the three myopic groups (all P < 0.05). The thickness of temporal nerve fiber layer in the control group was significantly lower than that in the high myopia group and the super high myopia group (P < 0.001, P = 0.002), and also significantly lower in the low myopia group than that in the super high myopia group (P = 0.043); the PPA of the four groups was statistically different (P < 0.001), in which the super high myopia group and the high myopia group was significantly greater than that in the low myopia group and the control group (P < 0.01); the HOT of the four groups was statistically different (P = 0.020), in which the high myopia group and the super high myopia group was significantly higher than that in the control group (P < 0.001, P < 0.001). The nerve fiber layer thickness in the upper and lower quadrants was negatively correlated with OI, HOT, and PPA (all P < 0.05), while the nerve fiber layer thickness in the temporal side was positively correlated with OI, HOT, and PPA (all P < 0.05). Conclusions：Mean and superior and inferior nerve fiber layer thickness was thinner in myopic patients, with temporal thickening and no change in the nasal side. The tilt of optic disc and the area of peripapillary atrophy were increased in high myopia, which were closely related to the thickness of nerve fiber layer.]]> 2019/11/6 16:11:07 2019/11/6 16:03:23 2019/11/6 14:42:30 0.05). The peripapillary RNFL thickness in OSAS group, especially in severe OSAS patients, was significantly lower than that in control group (P = 0.047).]]> 2019/11/6 8:43:33 2019/11/5 18:04:44 2019/11/5 15:11:43 2019/11/5 14:39:47 2019/11/5 14:20:49 2019/11/4 17:02:45 2019/11/4 16:31:44 2019/11/4 10:54:52 2019/11/4 9:58:12 0.05). The total effective rate of treatment in group A at 6 months after surgery was obviously higher than that in group B (97% vs.71%, P=0.013). There was no difference in visual field between the two groups during the follow-up period (P=1.000). The incidence rates of corneal edema and hyphema in group A were lower than those in group B (P<0.05). Conclusion Intravitreal injection of ranibizumab combined with trabeculectomy for treating NVG can effectively decrease and maintain intraocular pressure and reduce the incidence of postoperative complications, with marked curative effect.]]> 2019/11/4 9:30:56 2019/11/1 11:28:43 0.05). There was no significant difference in data between the two groups before treatment (P > 0.05).Indexes except NITMH and MGP each time point after treatment in the two groups were significantly improved compared with those before treatment, and the difference was statistically significant (P < 0.05). There was no significant difference in each index between the experimental group and the control group at 1 week after treatment (P > 0.05); at 4, 7 and 12 weeks after treatment, the experimental group was superior to the control group except for NITMH and MGP, and the difference was statistically significant (P < 0.05). From the change trend of the indicators, the therapeutic effect of the experimental group continued to improve after the first treatment, and was the best at the 12th week, while that of the control group was the best at the 7th week after the first treatment, and then the curative effect was weakened. There were no obvious complications in both groups after treatment. Conclusion:Both intense pulsed light combined with palpebral gland massage and eyelid fumigation massage are convenient, safe and effective for MGD-related dry eyes, and the curative effect and maintenance time of intense pulsed light combined with palpebral gland massage are better than that of eyelid fumigation massage.]]> 2019/11/1 11:02:38 2019/10/31 18:17:40 0.05). Conclusion: SFCT and LCVT in patients with early active Graves ophthalmopathy are thickened, and MCVT has no obvious change, suggesting that EDI-OCT measurement of SFCT and LCVT has certain reference value for evaluating early active Graves ophthalmopathy.]]> 2019/10/30 13:43:38 2019/10/29 9:20:05 2019/10/29 9:05:29 0.05）. There was no significant difference in the c visual acuity, incidence of epiphora among 3 groups（p>0.05）. The recurrence rate of C group were significantly higher than A group and B group（p<0.05）. The incidence of postoperative complications of C group were significantly higher than A group and B group（p<0.05）. Conclusion Compared with 12 weeks after tube implantation, 6 weeks and 9 weeks after tube implantation on patients with chronic dacryocystitis after lacrimal drainage tube implantation h CMV-positive possess the better clinical benefits.]]> 2019/10/28 9:49:51 2019/10/25 14:14:31 2019/10/24 10:32:49 2019/10/11 17:39:51 0.05). In terms of complications, group A was significantly superior to group B. CONCLUSION:Trabeculectomy combined with dexamethasone iontophoresis or peribulbar injection of methylprednisolone can effectively control postoperative intraocular pressure and anterior chamber inflammation in patients with acute angle-closure glaucoma complicated with diabetes mellitus.Among them, the effect of combined dexamethasone iontophoresis in reducing complications is better and patients suffer less pain. KEYWORDS:Trabeculectomy; Iontophoresis; Week of ball injection; Acute angle-closure glaucoma; Diabetes]]> 2019/10/11 16:48:12 0.05). After surgery, level of VEGF, IL-6 and intraocular pressure in both groups all decreased, and the PEDF water in the research group was lower than that in the control group, while the PEDF water in the two groups was increased, and the research group was higher than that in the control group (P<.0.05). The visual acuity improvement rate in the research group was higher than that in the control group (P<0.05). The rate of drainage tube obstruction and anterior chamber bleeding in the research group was lower than that in the control group (P<0.05), and there was no statistical difference between the two groups in corneal edema, anterior chamber exudation, eyeball pain, shallow anterior chamber and low intraocular pressure rate (P>0.05). Conclusion: Ahmed glaucoma drainage valve implantation combined with rezuzumab can effectively regulate the expression of cytokines, reasonably control the intraocular pressure, and improve the visual function of patients, which is a safe and effective treatment for patients with NVG.]]> 2019/10/11 11:07:11 2019/10/11 10:43:10 2019/10/11 10:28:49 2019/10/11 8:51:46 0.05). The difference of SphA, k1, k2 and CA between iTrace and pentacam was close to 0, the consistency was good because of the narrow 95% confidence interval. Conclusion: There is no significant difference of the measurement result between iTrace and pentacam, the consistency is good, and both can be used as a mutual reference in clinical.]]> 2019/10/10 14:08:21 0.05). (3) SE was negatively correlated with ALand ACD ( P＜0.01), but had no correlation with ACD,LT and K. CONCLUSION: The ?change? of AL plays an important role affecting the refractive state of preschoolers with hyperopia ametropia, which is manifested as higher the hyperopia diopter,the shorter AL and the ?shallower vitreous cavity, which are co-involved in the change of refractive state, while the hyperopic degree has no correlation with ACD, LT and K. The axial refractive error is the main refractive error in preschoolers.]]> 2019/10/10 12:46:26 0.05). The central corneal ECDs statistically decreased at 1 week postoperatively in three groups， compared to preoperatively (all p = 0.000), while the ECDs recovered at 1 year postoperatively. The changes of CVs and the percentage of hexagonal endothelial cells at 1 week, 1 year after operation were not statistically significantly different compared with preoperative results in the three groups (all p > 0.05). The differences of ECD, CVs, and the percentage of hexagonal endothelial cells among three groups at preoperatively and postoperatively were not statistically significant (all p > 0.05). Conclusion The SBK, FS-SBK and SMILE used to treat myopia were safe for the corneal endothelium. The central corneal ECDs decreased slightly at early period after operation, and recovered 1 year later in all groups. The CVs and percentages of hexagonal endothelial cells in three groups do not change at short-term and long-term postoperatively. The differences of ECD, CVs, and the percentage of hexagonal endothelial cells among three groups were not found at postoperatively.]]> 2019/10/9 16:49:50 2019/10/9 16:45:34 0.05). The intraocular pressure and PNFLT in the observation group were significantly lower than those in the control group at 3 months after operation (P < 0.05). The incidence of complications in the observation group and the control group were respectively 12.50% and 25.00% without significant difference (P > 0.05). T The success rates of operation in the observation group and the control group was respectively 95.83% and 75.00% with significant difference (P < 0.05). Conclusion: The treatment of with P50 EX-PRESS drainage nail combined with biological amniotic membrane implantation in patients with POAG is satisfactory. It can improve the condition of filtering blebs, reduce intraocular pressure and RNFLT. It is safe and has a high success rate, which is worth popularizing.]]> 2019/10/9 10:53:09 2019/10/9 10:18:01 2019/10/9 10:14:12 0.05). There was no significant difference in BCVA at different time points within the three groups and between the groups (P>0.05). There were no significant differences in the spherical degree, cylindrical degree and spherical equivalent degree among the three groups at different time points (P>0.05). There was a statistically significant difference in the vector change value of subjective optometry refractive power (F=7.404, P<0.05), and the vector change value of subjective optometry refractive power in low curvature group was lower than that in middle curvature group and high curvature group (t=6.158, 4.886, P<0.05). Multivariate linear regression equation showed preoperative spherical equivalent was the related factor affecting the refraction state of corneal center (6 mm) after SMILE (P<0.05). Conclusion: SMILE can better improve the visual acuity of patients with different curvature myopia, and it is safe and effective, but there is postoperative refractive error in patients with low curvature myopia, and the preoperative spherical equivalent is the factor affecting the refraction state of corneal center (6 mm) after SMILE.]]> 2019/9/30 10:03:33 2019/9/30 8:34:32 2019/9/29 14:44:42 2019/9/29 14:35:59 2019/9/29 14:20:22 2019/9/29 14:11:46 2019/9/29 14:07:23 2019/9/29 14:00:46 700μm) underwent vitrectomy in our hospital from March 2016 to March 2018 were retrospectively analyzed, in which group A (17 patients) underwent vitrectomy and internal limiting membrane peeling generally, group B (18 patients) underwent vitrectomy and internal limiting membrane transplantation. The best corrected visual acuity(BCVA) and macular hole closure rate were performed pre-operation and 3 months post-operation. Results：The macular hole closure rate in group A was 65% at 3 months after surgery, and macular hole closure rate in group B was 100% at 3 months after surgery(P<0.05).The rate of BCVA of A group which w ere significantly improved at 3 months post-operation(Increase by 2 lines or more) compared pre-operation is35%, and the rate of BCVA of B group is 78% (P<0.05). Conclusion：Internal limiting membrane transplantation can improve the closure rate of large macular hole and visual function after surgery in a certain extent. It is a safe and effective surgical method.]]> 2019/9/27 10:30:37 2019/9/25 16:37:55 2019/9/25 9:52:29 2019/9/25 8:37:10 2019/9/23 11:29:40 0.05).There was no significant difference in blood glucose level of T2DM rats after saline injection (P > 0.05).After dexamethasone was injected in different ways, the concentration of T2DM rats in subconjunctival bulbar＞bulb reached its peak in the experimental group.Dexamethasone concentration of aqueous humor in rats after dexamethasone injection in different ways was statistically significant (P < 0.05).Conclusion Dexamethasone injection through the three approaches had no significant effect on blood glucose in T2DM rats, while subconjunctival dexamethasone injection was simple and could reach higher drug concentration in a short time than the peribulbar and post-bulbar approaches.For dexamethasone route, subconjunctival injection route is superior to peribulbar and retrobulbar route.]]> 2019/9/23 8:09:35 2019/9/19 18:26:41 2019/9/18 11:25:06 2019/9/11 9:26:36 2019/9/10 15:51:57 2019/9/10 10:43:18 2019/9/10 9:20:21 2019/9/9 11:01:59 2019/9/6 14:45:44 2019/9/6 8:56:35 2019/9/5 16:48:03 2019/9/5 16:38:49 2019/9/5 16:32:49 2019/9/5 16:16:31 2019/9/5 10:37:22 2019/9/4 12:13:37 2019/9/4 12:03:12 2019/9/4 10:25:32 2019/9/3 18:32:45 2019/9/3 16:07:09 0.05). The total success rate was 87%(20/23) in the low-power group while 83%（19/23）in the conventional parameter group (P=1.000).The overall incidence of complications of the low-power group(39%) was lower than that of the conventional parameter group（78%）(P=0.007) at post-operative 3 mo . The early postoperative pain score of the low-power group was significantly lower than that of the conventional parameter group(P=0.007). Conclusion：Compared with conventional parameters,TSCP with lower power may reduce IOP similarly with less pain and fewer complications.]]> 2019/9/2 15:32:19 45 years) who participated in the physical examination in ophthalmology clinic of Yuncheng First Hospital during Feb 2018 to Feb 2019 were included in the cross-sectional study. The clinical information (including sex, age, family history of ARMD, etc.) and biochemical indices (including 25-hydroxyvitamin D [25(OH)D], etc.) were collected. The correlations between serum 25(OH)D level and clinical information, as well as biochemical indices, were analyzed. The outpatients were divided into ARMD group (231 cases) and non-ARMD group (192 cases) according to the ARMD situation in the study. The correlation between Vit-D deficiency and ARMD was analyzed. RESULTS：Serum 25(OH)D level was positively correlated with the male, duration of outdoor light exposure(P<0.05),and negatively correlated with age, smoking and drinking (P<0.05).Binary logistic regression analysis showed that Vit-D deficiency was a risk factor associated with ARMD(OR=1.980,95% CI:1.829-2.201,P<0.01). Other associated factors included age, sex, hypertension, diabetes, low-density lipoprotein cholesterol(LDL-C), and duration of outdoor light exposure>5h,which were also risk factors associated with ARMD. CONCLUSIONS：Nutritional imbalance due to Vit-D deficiency might be associated with the occurrence of ARMD. Appropriate sun exposure or vitamin D supplements could contribute to preventing the development of ARMD.]]> 2019/9/2 15:23:36 2019/9/2 11:37:50 2019/9/2 10:53:34 2019/8/27 10:22:11 2019/8/27 10:07:28 2019/8/26 14:06:59 2019/8/26 11:42:33 2019/8/22 16:22:34 2019/8/22 16:21:26 2019/8/22 16:21:04 1.0D)were enrolledandacceptedphacoemulsificationcombinedwithimplantation of intraocularlens(IOL)in our hospitalduringDecember 2017 and December 2018.Fortycases(56eyes)weredividedintotwogroupsaccordingto whichIOLthey chose,multiple focal astigmatism(909M)groupincluded23cases(35eyes),single focal astigmatism(709M)groupincluded 17cases(21 eyes), Three monthspostoperatively,thevisualacuity，defocuscurve, residual astigmatism degree, rotationalstabilityof the IOL, postoperative visual quality analysis and patient satisfactionwereevaluated. RESULTS：At3monthspostoperatively,uncorrected distance visual acuity (UDVA)andcorrected distanceacuity in the two groups were significantly improved (P<0.05).The defocus curve showed that 909Mgrouphad two visual acuity peaks at 0D and -2.5D, and a low peak at -1D—-2.5D, 709Mgroup had the visual peak only at 0D.Spectacle independency was achieved by 91%（21/23）of patients in the 909M group and 18%（3/17）in the 709M group. CONCLUSION：Both ofthe909M and 709M had good correction effect for cataract combined with astigmatism,Itprovidedbetter rotational stability. In addition,909M providedexcellentdistance,nearvisualoutcomes,and acceptable intermediate vision.Atthesametime,it improved thespectacle independencyand satisfaction of cataract patients combined with astigmatism.]]> 2019/8/13 10:52:48 2019/8/13 10:22:44 2019/8/12 21:21:25 0.05).In terms of patients' scores of conscious symptoms and signs, degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion, the experimental group was significantly improved 7 days after treatment, and the effect was more significant with the prolonged treatment, while the control group was gradually improved 14 or 28 days after treatment. At the same treatment time point, the efficacy of the experimental group was significantly better than that of the control group, and the difference was statistically significant (P<0.05).With the improvement of the condition after treatment, the anxiety or depression symptoms of the patients were improved. The experimental group was significantly improved 7d after treatment, while the control group was gradually improved 14d or 28d after treatment. At the same treatment time point, compared with the control group, the anxiety and depression degree of the patients in the experimental group were significantly reduced (P<0.05). Conclusion: Praprofen eye drops has a quick onset and significant curative effect in the treatment of xerophthalmia. Patients' self-consciousness symptoms and signs are significantly improved, conjunctival congestion and corneal fluorescein staining are reduced, tear breakup time is prolonged, tear secretion is increased, and anxiety or depression are significantly improved.]]> 2019/8/12 14:12:37 0.05). The levels of HbAlc and FPG in the group with good prognosis and the group with poor prognosis were significantly higher than those in the control group (P < 0.05), and the group with poor prognosis was significantly higher than that in the group with good prognosis (P < 0.05). The serum levels of microRNA93 and microRNA21 in patients with poor prognosis were significantly higher than those in patients with good prognosis and controls (P < 0.05); COX regression analysis showed that the serum levels of microRNA93 and microRNA21 were independent risk factors affecting the progression of DR patients; ROC curve analysis showed that the area under the combined detection curve of microRNA93 and microRNA21 was 0.946, specificity was 95% and sensitivity was 96% higher than that of single detection. The difference was statistically significant (P < 0.05). Conclusion: The abnormal increase of serum levels of mi93 and mi21 in patients with diabetic retinopathy is an independent risk index affecting the progress of DR. The combined detection of mi93 and mi21 has high diagnostic value for early DR.]]> 2019/8/12 11:52:03 2019/8/12 11:41:12 2019/8/12 11:36:50 0.05).There were no serious complications in the UCP group,four eyes appeared conjunctival hyperemia and one eye appeared superficial punctuate keratitis;but there were 16 eyes (80.00%) in the cyclocryotherapy group:ten eyes appeared conjunctival hyperemia and six eyes appeared anterior chamber hemorrhage. Conclusion UCP is safe and convenient surgery for refractory glaucoma,and has significant effect on reducing intraocular pressure,alleviating ocular pain and decreasing complications.]]> 2019/8/9 11:21:53 0.05). There was a statistically significant difference in the clinical efficacy of mild, moderate and severe amblyopia (P<0.05). The total clinical effective rate of children with mild and moderate amblyopia was higher than that of children with severe amblyopia (P<0.05), and there was no significant difference in the total clinical effective rate between children with mild amblyopia and children with moderate amblyopia (P>0.05). There was a statistically significant difference in the perception level of eye position among strabismus group, amblyopia group and control group (P<0.05). The perception level of eye position before treatment in strabismus group and amblyopia group was higher than that in control group, and the perception level of eye position before treatment in strabismus group was higher than that in amblyopia group (P<0.05). The perception level of eye position after treatment of children with strabismus or amblyopia was significantly lower than that before treatment (P<0.05). The poor visual acuity of children with strabismus or amblyopia after treatment was significantly improved compared with that before treatment (P<0.05). The difference of poor visual acuity was positively correlated with difference of perceptual eye position before and after treatment among children with strabismus or amblyopia (r=0.371, P<0.05). Conclusions Visual perception impairment training can effectively improve the visual representation and binocular vision function of children with strabismus or amblyopia, and it is suitable for the clinical treatment of children with strabismus or amblyopia.]]> 2019/8/9 11:03:47 2019/8/8 16:16:33 2019/8/8 14:10:36 2019/8/8 13:34:38 2019/8/8 13:33:37 2019/8/7 16:20:45 0.05). And compared with 1 month postoperatively, there was a significant decrease in corneal subepithelial dendritic cell density (P<0.05) and a significant increase in corneal epithelial nerve density(P<0.05) at 3 month postoperatively; while there was no significant difference in uncorrected visual acuity, OSDI, corneal fluorescence staining, corneal epithelial thickness, full corneal thickness and corneal endothelial cell density (P>0.05). Conclusion: ASP was effective for CED. Corneal confocal microscopy was essential for the evaluation of ASP efficacy, which can guide the clinical work better and establish the termination of intervention.]]> 2019/8/7 16:11:07 2019/8/7 9:51:23 2019/8/6 10:54:59 2019/8/2 8:58:54 2019/8/1 14:02:02 2019/8/1 13:49:18 0.05) with respect to in age, sex, duration of disease, best corrected visual acuity (BCVA), the mean intraocular pressure (IOP) and the mean central macular thickness (CMT). Patients in the control group received the surgical procedure of laser photocoagulation while the combination therapy of both laser photocoagulation and ranibizumab were used to treat patients in the experimental group. BCVA, IOP and CMT were assessed at 1 week and 3 months after treatment, and the collecting data of these two groups were compared and examined by analysis of variance (ANOVA) with repeated measures, LSD-t test, χ2 test and independent sample T-test. • RESULTS: Before treatment (t=-0.31), 1 week (t=-1.43) and 3 months (t=-0.8) after treatment, there was no significant difference of IOP between the control group and the experimental group (P>0.05). 1 week (t= -7.83), along with 3 months after treatment (t=-8.80), the CMT in the experimental group was significantly lower than that in the control Group (P<0.05). 1 week (t=-3.76) and 3 months after treatment (t=-4.09), the BCVA in the experimental group was significantly higher than that in the control group (P<0.05). The BCVA of the experimental group was significantly increased after the treatment for 1 week (LSD-t=1.97, P<0.05). The recurrence rate of the experimental group was significantly lower than that of the control group (χ2=4.59, P<0.05). There were no significant differences in the incidence of early elevated intraocular pressure between the two groups (χ2=0.03, P>0.05). No retinal detachment or intraocular inflammation occurred in both groups. • CONCLUSION: Compared with the single treatment of laser photocoagulation, the combination therapy of laser photocoagulation and ranibizumab could significantly lower the CMT after surgery, bring the improvement and early improvement of the BCVA and decrease the recurrence rate as well.]]> 2019/7/31 19:31:33 2019/7/31 14:33:26 0.05)）The BCVA was increased significantly in both groups（F25G=55.23,P25G<0．01；F27G=52．79，P27G<0．01）．but there was no significant difference in terms of visual improvement between the two groups((F=9.222, P>0.05)．The mean surgical time in the 25G group was(44.13±5.9)min,which was no significant difference than that of 27G group (46．07±6.1)min(t=0．028，P=0．412).The primary anatomical success rate after a single operation was 91％and 93％for 25 G and 27G group respectively(=0.015,P=0.902).There was no significant difference about hypotony(<6mmHg,1mmHg=0.133kPa)between the 25G group(15.2%) and the 27G group (10%)，(=0.376，P=0．540).No serious complication such as choroidal detachment and endophthalmitis was observed in both groups． CONCLUSION：This study finds no significant differences in the surgical time, the rate of reattachment of retina,improvement of BCVA and complications between the 25G or 27G vitrectomy for rhegmatogenous retinal detachment with air tamponade. 27G vitrectomy with air tamponade seems to be a safe, economical and effective surgery for RRD.]]> 2019/7/31 11:04:39 0.05).The corneal endothelial cell density after operation for 3 months in the observation group was significantly higher than that in the control group (P < 0.05).There was no significant difference in the best corrected visual acuity (BCVA) and uncorrected visual acuity (UCVA) between the two groups (P > 0.05).The BCVA and UCVA after operation for 3 months in the observation group were better than those in the control group (P < 0.05).There was no significant difference in complications between the two groups (P > 0.05). Conclusion: The effects of femtosecond laser-assisted phacoemulsification combined with multifocal intraocular lens implantation in treatment of cataract are significant,which can reduce the cumulative release of ultrasound energy, reduce corneal endothelial damage, and promote visual recovery of patients,thus it is safe and it is worthy to be promoted.]]> 2019/7/31 10:46:13 0.05). CONCLUSIONS：The average BCVA and the mean CMT of patients with macular edema secondary to RVO after treatment was significantly better，and it is not progressive macular ischemia in the short-term after a single intravitreal injection of an anti-VEGF agent]]> 2019/7/31 9:17:37 0.05). Compared with the baseline values before surgery, the thickness of corneal epithelium in the three areas was significantly thickened 1 week after surgery, 1 month after surgery and 6 months after surgery (P < 0.05).The changes of corneal epithelium thickness in the three areas showed a significant decreasing trend from the central corneal area to the peripheral area, that is, the corneal epithelium thickened in the shape of a convex lens. The values of corneal epithelium thickness in the central and para-central areas were positively correlated with the equivalent sphericity and ablation depth, but there was no significant correlation with the optical zone. CONCLUSIONS: The corneal epithelial thickness increases after SMILE in different regions, and the thickening value was positively correlated with the spherical equivalent、ablation depth. Key words: Myopia; SMILE; Epithelial thickness]]> 2019/7/30 16:06:26 2019/7/30 14:09:16 2019/7/30 9:12:43 2019/7/29 13:46:55 2019/7/29 10:30:24 0. 05). There was no significant difference between the two groups before treatment in eye axis (orthokeratology group 24.84 ±0.90mm, glasses group 24.78 ±0.86mm, t = 0.550, P > 0. 05). PRA in the orthokeratology group (-2.27 ±0.37)D was significantly higher than that in the pre-treatment group(-0.83±0.23)D（t=37.070,P<0.05). There was no significant difference in PRA (-0.83 ±0.24)D at the end of 6 months compared with that before treatment (-0.77±0.24)D，(t = 1.565, P > 0. 05). The eye axis of the orthokeratology group (24.86 ±0.91)mm was significantly higher than that of the control group(24.84±0.90)mm，(t = 2.453U, P < 0. 05) at the end of 6 months. The eye axis of the glasses group (24.97±0.86) mm was significantly different from that before treatment(24.78±0.86)mm， (t=39.135,P<0.05).There was no significant difference in the eye axis between the orthokeratology group and the glasses group after 6 months (t=-0.932 P>0.05). Conclusion: the corrected visual acuity of juvenile myopia by orthokeratology was significantly higher than that by using glasses 6 months after treatment, but there was no significant difference between the two groups in eye axis during 6 months.]]> 2019/7/26 10:00:04 2019/7/25 13:53:45 2019/7/25 13:47:15 2019/7/12 14:13:38 2019/7/10 17:17:18 2019/7/10 16:37:24 2019/7/9 16:00:21 0.61). The positive rate of diabetic retinopathy was significantly higher in patients with diabetes mellitus over 10 years, the difference is significant(p<0.05). Conclusion Routine retinal examination in hospitalized diabetic patients is an effective method for early detection and early intervention. It is of great significance to reduce the blindness rate of diabetic retinopathy.]]> 2019/7/9 15:44:25 2019/7/9 8:54:33 2019/7/8 11:45:53 0.05). Two weeks after treatment, the total score of symptoms and signs in the observation group was lower than that in the control group (P<0.05), and the clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions Olopatadine eye drops combined with autologous serum in the treatment of artemisia pollen allergic conjunctivitis has a definite clinical effect, and can effectively improve the clinical symptoms and signs of patients with high safety.]]> 2019/7/8 10:50:37 0.05). Conclusion: The phacoemulsification under corneoscleral limbus incision can improve postoperative visual acuity of elderly cataract patients, reduce the corneal astigmatism, reduce the influence on the tear film function, and promote postoperative rehabilitation .]]> 2019/7/5 16:03:41 2019/7/5 15:53:25 2019/7/5 10:54:15 0.05）. In terms of intraocular pressure, it is not significant at the last follow-up. Postoperative complications included anterior chamber reaction, transient intraocular pressure, corneal edema, and macular edema. The incidence rate was significantly higher in group B (87.50%) than in group A (55.88%) (P=0.034<0.05). The retinal thickness of foveal was higher in group B than in group A, and higher postoperative than preoperative, and the postoperative thickening was more obvious in group B than in group A, and the differences were statistically significant (P<0.05). Conclusion In diabetes patients ,the preoperative HbA1C level is related to the complications after cataract surgery and the retinal thickness of foveal. The higher the HbA1C, the more postoperative complications, the higher the retinal thickness of foveal, and the worse the postoperative visual acuity.]]> 2019/7/5 10:48:18 2019/7/5 10:36:18 2019/7/5 10:20:23 0．05)．The BCVA at 1 month after surgery was0.36±0.35，which was improved compared with the preoperative one, but the difference was not statistically significant(P>0．05)．At 3 month after surgery, the UCVA was 0.42±0.34, the BCVA was 0.34±0.36(p>0．05 ). Three cases had transient intraocular hypertention postoperatively. One case had vetrious hemorrhage. One case had moderate anterior chamber inflammatory response. There were on serious complications, such as cystoid macular edema，choroidal detachment ,retinal detachment during the follow up period． Conclusion Ciliary sulcus suture fixation of intraocular lens through reverse partial-thickness scleral flap is a effective and safe method for aphakia.]]> 2019/7/5 10:10:10 0.438).The intervention factors and time of the experimental group and the control group had influence on postoperative intraocular pressure (F group =8.67, P<0.01).F time =127.58, P<0.01);There was an interaction between the two groups (intergroup * time =7.5, P<0.01).Intervention factors in the experimental group and the control group had no effect on postoperative visual acuity (F group =0.48, P=0.49), and the improvement of postoperative visual acuity in the two groups was statistically significant (F time =72.03, P<0.01).There was no interaction between the two groups (time between F groups * =0.96, P=0.45). Conclusion: Phaco-ExPress for the refractory open-angle glaucoma combined with cataract is safe and effective, and the operation time is shorter, so it can be used as a conventional combination surgery. Keywords: Phaco-ExPress;Refractory open-angle glaucoma;Cataract;Intraocular pressure;Postoperative complications]]> 2019/7/4 14:43:15 2019/7/4 10:06:34 2019/7/3 10:00:49 0.05). None of subjects developed cataract, glaucoma and decompensation of corneal endothelium. The degree of postoperative satisfaction was 100%. Conclusion ICL V4c implantation is a safe and effective method for the correction of low to moderate myopia. The visual acuity stabilized 1month after operation..]]> 2019/7/1 11:23:47 0.05). But 3 months after surgery, BUT and SIT of the stem cell group was higher than the membrane group (P<0.05). OSDI of the stem cell group was better than the membrane group (P<0.01). (2) Compared within group, BUT, SIT and OSDI were no significant differences between before operation and 1 month after surgery (P>0.05), but there were significant differences between 3 month after surgery and 1 month after surgery, before operation(P<0.05). Conclusions The function of tear film was restored by Pterygium excision combined with amniotic membrane transplantation or combined with autologous limbal stem cell transplantation, and the later was better than the former in effect.]]> 2019/7/1 11:16:51 0.05), while the high and medium and low groups showed statistical difference (P < 0.05).Non-oppression whitening (WWP) showed that there was a statistical difference between the low, medium and high groups (P < 0.05), while there was no statistical difference between the medium and high groups (P=0.815 > 0.05).There was no significant difference between the moderate, low and high STD groups (P > 0.05), and the low and high STD groups (P=0.017 < 0.05).SD, WWP and CD showed that there was no statistical difference between middle school, primary school and high school (P > 0.05), while there was statistical difference between primary school and high school (P < 0.05).LD, STD, and RP showed statistical difference between primary school, middle school and high school (P < 0.05), while there was no statistical difference between middle school and high school (P > 0.05).There was no significant difference in DRP between junior high school, primary school and senior high school (P > 0.05), while there was significant difference between primary school and senior high school (P < 0.05). Conclusions:The prevalence of peripheral retinal degeneration of myopia was positively correlated with diopter and segment.]]> 2019/7/1 11:07:21 2019/7/1 9:53:32 2019/6/28 11:27:38 2019/6/28 11:08:06 2019/6/25 11:14:25 2019/6/25 9:45:45 0.05).The MTF cut off, OSI and OV9% values of the ICL group were better than those of the FS-LASIK group at 3mo postoperatively, with statistically significant differences (P<0.05).The MTF cut off and OSI of 3mo in the ICL group were better than those before implantation, and the differences were statistically significant (P<0.05). •CONCLUSION: Both ICL implantation and FS-LASIK can effectively improve the visual acuity and diopter of patients, After ICL implantation, the MTF cut off value and OV9% value are higher than FS-LASIK, the postoperative OSI value is lower than FS-LASIK. •KEYWORDS: Implantable collamer lens; High myopia；femtosecond; Keratomileusis laser in situ; double-pass optical quality analysis system；visual quality]]> 2019/6/21 9:10:16 T in exon 11 of PAX6 was exclusively observed in all affected individuals but not in any of the unaffected family members or unrelated controls, which results in the truncation of encoding protein（R331X）. Conclusions: We identified a novel mutation in the PAX6 R331X, which may be responsible for the pathogenesis of congenital aniridia and cataract.]]> 2019/6/20 15:07:07 2019/6/19 15:16:20 2019/6/6 14:38:33 2019/6/6 14:13:17 0.05). At the last follow-up, no serious eye complications occurred in this group, and the total satisfaction was 94%. Conclusion: Non-astigmatic posterior chamber implantable intraocular lens is a safe and effective solution for high myopia with moderate astigmatism. Key words: posterior chamber implantable intraocular lens, high myopia, moderate astigmatism]]> 2019/6/6 10:53:40 2019/6/6 10:47:43 0.05).The blood flow parameters of OA, CRA and RCA in the severe stenosis group were lower than those in the other three groups (PSV and EDV), and the difference was statistically significant (P<0.05).Correlation analysis showed that PSV and EDV in the blood flow parameters of OA, CRA and PCA were significantly negatively correlated with severe intracranial internal carotid artery stenosis, and PCA was more sensitive to severe intracranial artery stenosis under the same index, while no correlation was found between other parameters and severe intracranial internal carotid artery stenosis.The area under the ROC curve of PCA PSV and PCA EDV was 0.722 and 0.761, respectively, which had high diagnostic value. The optimal critical values were 11.26cm/s and 5.21cm/s, respectively.Conclusion There was no correlation between retinal vascular morphology and intracranial internal carotid artery stenosis. Severe internal carotid artery stenosis was significantly negatively correlated with ocular ultrasound parameters PSV and EDV. The most sensitive to severe stenosis under the same index was PCA PSV and PCA EDV. Can be used as an indicator of severe stenosis.]]> 2019/6/6 10:31:51 2019/6/5 14:13:26 0.05). BCVA in group A 6 months after operation was significantly lower than that in group B at the same time (P < 0.05). There was no significant difference in central and paracentral scotomas before operation between group A and group B (P > 0.05). Compared with group B at the same time, the central dark points in group A were significantly less at 6 months after operation (P < 0.05). The incidence of complications in group A was 11.36%, compared with 9.09% in group B, there was no significant difference (P > 0.05). Conclusion: In the clinical treatment of MCHI < 0.7 IMH, enlarged internal limiting membrane dissection is more effective than standard internal limiting membrane dissection. The former has better effect on the recovery of retinal function and is worthy of clinical application.]]> 2019/6/4 14:34:10 2019/6/4 10:32:15 2019/5/31 11:16:58 2019/5/31 11:07:54 2019/5/30 15:39:27 0.05). Conclusions: Retinal photocoagulation combined with conbercept can effectively reduce the aqueous humor VEGF and SDF-1 in patients with DR, which is conducive to improving the therapeutic effect of patients, and it is safety, it’s worth for further clinical promotion.]]> 2019/5/30 14:52:14 2019/5/30 10:35:19 30mmHg.The uncorrected distance visual acuity(UDVA), corrected distance visual acuity（CDVA）, diopter, intraocular pressure and corneal endothelial cell density were observed at 1 day, 1 w, 1 m, 3 m, 6 m, 1 Y and 2 Y after operation.SPSS 22.0 was used for statistical analysis. Paired t-test and one-way ANOVA with repeated measures were used for data comparison. The difference was statistically significant when p < 0.05. Results: ICL V4c was implanted successfully in all patients by this improved skills and fine clinical results were achieved.About spherical equivalent refractive error,101 eyes(74.2%)were within ±0.5D 6 months after the operation.123 eyes (87.2%)postoperative UDVA reached the preoperative CDVA.17 eyes (12.1%) had elevated IOP >30 mmHg at 2 hours after operation,and 21 eyes (14.9%)at 4 hours, while 6 eyes (4.3%) at 6 hours after operation had IOP between 21 and 29 mmHg .135 eyes (95.7%) had normal IOP 6 hours after operation.The postoperative IOP was stable within 2 years follow-up period. there was no significant difference between preoperative and postoperative intraocular pressure at 1w, 1m, 3m, 6m, 1Y and 2Y. The cumulative corneal endothelial loss rates of 6M, 1Y and 2Y were 4.70%, 7.59% and 9.63% respectively.There was no subcapsular cataract and no complications such as endophthalmitis during the follow-up period. Conclutions: The improved skills used in our study is safe and feasible that can reduce the wounds and the use of viscoelastics. The skill clearing viscoelastics during the operation is simple and practical.]]> 2019/5/30 10:05:14 2019/5/30 9:47:43 2019/5/29 19:53:20 2019/5/29 15:10:43 4.65?0.67mmol/L,P=0.006; 1.57?0.95mmol/L>1.29?0.55mmol/L, P=0.011; 3.31?0.92mmol/L>2.86?0.62mmol/L, P=0.035; 0.98?0.26g/L>0.86?0.15g/L, P=0.021). HDL-C and APOA1 levels were lower in pterygium group than control, but there were not significance (P>0.05). Statistically significant differences were present for the LDL-C levels among pterygium groups graded clinically (2.76?0.57mmol/L, 3.40?0.96mmol/L and 3.85?1.16mmol/L, P=0.036), but were not present all for TC, TG, HDL-C, APOA1 and APOB levels (P>0.05). Comparing the groups, LDL-C values were significantly higher in group3 than in group1 (3.85?1.16mmol/L>2.76?0.57mmol/L, P=0.012) , while there was no significant difference between Group3 with Group2 and Group2 with Group1 (P>0.05), respectively. Conclusions: Hyperlipidemia has close relationship with bilateral primary pterygium and may be one of its risk factors.]]> 2019/5/29 15:04:19 2019/5/28 16:10:14 2019/5/28 14:53:43 2019/5/28 9:45:57 2019/5/28 9:05:00 2019/5/27 9:58:29 2019/5/24 10:45:00 2019/5/24 10:14:35 2019/5/24 10:00:02 2019/5/24 9:33:28 2019/5/24 9:15:25 2019/5/22 9:08:21 0.05). In the ocular factors of the two groups, whether there was proliferation of fibrovascular membrane in the fundus, the status of the lens, whether there was hemorrhage in the optic disc neovascularization, and whether the intravitreal injection of anti-vascular endothelial growth factor was compared before surgery (P<0.05). The other eye factors were compared (P>0.05). After Logistic regression analysis, fibrovascular membrane proliferation and hemorrhage of optic disc neovascularization were independent risk factors for early vitreous hemorrhage. CONCLUSIONS: In patients with proliferative diabetic retinopathy treated with 23G vitrectomy, early postoperative hemorrhage mainly occurred in severe retinal lesions, and fibrovascular membrane proliferation and optic disc neovascular hemorrhage were independent risk factors for early vitreous hemorrhage. It will increase the risk of early bleeding.]]> 2019/5/8 9:29:43 0.05). At the postoperative 1wk and 1mon, BCVA and intraocular pressure of the observation group were lower than those of the control group (P<0.05). The preoperative VEGF had no difference (P>0.05). At the postoperative 1mon, VEGF and macular fovea thickness of the observation group were lower than those of the control group (P<0.05). The total complication rate of the observation group was lower than that of the control group (10.7% vs 28.4%, P<0.05). Conclusion The application of ranibizumab combined with vitrectomy can reduce the operation difficulty, as well as promote the recovery of visual acuity and intraocular pressure level for diabetic retinopathy patients accompanied by neovascular glaucoma.]]> 2019/5/7 9:49:34 0.05). Noninvasive tear film break-up time（NI-BUT）in the conventional group was shorter 1 week, 1 month and 3 months after operation（P＜0.05），while it was shorter in 1 week and 1 month after operation in femtosecond laser group(P < 0.05). There was significant difference between conventional group and femtosecond laser group at 3 months after operation in NI-BUT (P=0.003，P=0.000）. Tear meniscus hight (TMH) and the thickness of lipid layers of the two groups all decreased in 1 week and 1 month after operation (P < 0.05) . CONCLUSION: Whether femtosecond-assisted or conventional LASIK will affect tear film stability and cause dry eye symptoms. The degree of influence decreases gradually with the time after operation, but femtosecond laser group can recover more quickly.]]> 2019/5/7 9:23:11 60 years old). Routine mydriasi was carried out in every patient. sThe operation time of patient interface, docking time, nucleus radius and pupil diameter before, during and after interface operation, best corrected visual acuity before and after surgery were recorded. The psychological and self-made questionnaire were filled out. RESULTS: ① The age of patients with femtosecond laser assisted cataract surgery was significantly negatively correlated with the diameter of the pupil before, during and after the interface operation, the radius of the nucleus, and the state anxiety（SAI） score. The interface operation time and the patient's SAI score were significantly negative correlation. ② The pupil diameters of the middle-aged and young patients were significantly greater than those of the elderly group before, during and after the interface operation. There was a statistically significant difference in pupil diameter between the two groups (P<0.01). ③ Forty-nine patinets (48.51%)with positive anxiety symptoms: 27 patients (26.73%)with mild state anxiety, 18 patients (17.82%) with moderate state anxiety, and 4 patients(3.96%) with severe state anxiety. ④ The interface operation time was 147.09±42.55 seconds and the docking time was 104.96±37.55 seconds in the group of middle-aged and young patients. In the old age group, the interface operation time of 140.89±28.60 seconds and the docking time of 98.64±16.69 seconds. There was no significant difference (P>0.05). The total effective rate of treatment in the young and middle-aged group and old group was 95.66% and 94.55% separatively. The difference was not statistically significant (P>0.05). Conclusion: The pupillary changes in young and middle-aged femtosecond laser-assisted cataract patients are more sensitive and these patients are prone to anxiety, which has certain influence on the progress of the surgery. We should pay more attention to the pupillary changes of patients of different ages and their emotional state, formulate effective measures, and implement effective management, so as to improve the patient's surgical cooperation and reduce surgical complications.]]> 2019/5/7 9:14:04 6.00D) who were examined in Hunan people’s hospital from August 2015to August 2016 were collected. SIRIUS system was used to measure WTW and HACD while UBM was used to measure S-S. SPSS20.0 was used for analysis. Bland-Altman method was used to analyze consistency of measurement methods.Results:WTWand HACD measured by SIRIUS system were （11.91?0.37）mm and （12.45?0.43）mm, while S-S measured by UBM was （11.78?0.46）mm. Correlation comparison on age-related factors: there were significant correlation between HACD, S-S and age (r=-0.423, -0.386, all P values were <0.05); Correlation comparison on anterior chamber depth (ACD) factors: Correlation analysis of group ACD≤3.5mm suggested that there were correlations between horizontal corneal diameter, anterior chamber diameter and ciliary sulcus diameter; Correlation analysis of group ACD＞3.5mm suggested that there were not any correlation between horizontalcorneal diameter, anterior chamber diameter andciliary sulcus diameter.Conclusion:1. The correlation between WTW and S-S is better, but is affected by ACD and age，when age ≥40years or ACD＞3.5mm, suggested using UBM to measure S－S ; 2.SIRIUS system is safe, simple and accurate in measurement of WTW and HACD.]]> 2019/5/6 15:38:54 0.05). Conclusion: Non-contact comprehensive ocular surface analyzer can observe the ocular surface characteristics of the patients non-invasively and provide relatively objective quantitative examination results. Ocular stability in patients with T2DM is lower than in patients without T2DM and hypertension, and ocular surface homeostasis of these patients is more likely to be broken. Key words Type-2 Diabetes Mellitus；Hypertension；Ocular surface；Tear film]]> 2019/5/6 9:27:01 2019/5/5 14:42:46 2019/5/5 11:45:35 2019/5/5 11:22:40 0.05).There was a statistically significant difference in retinal reattachment rate after removal of silicone oil-filled eyes (P<0.05). Conclusion: Non-posterior retinal multiple-tear detachment are mostly caused by extensive retinal degeneration or combined with vitreous traction. Vitrectomy should be chosen in complex cases, but multiple operations are required, while the long-term result of scleral buckling is stable. The choice between vitrectomy and scleral buckling needs comprehensive consideration, and it should be avoided to enlarge the indications for vitrectomy blindly. However, scleral buckling should be preferred if possible, for younger or special groups such as those with one eye.]]> 2019/5/5 11:18:50 0.05). The best corrected visual acuity was improved, Ops wave amplitude was increased and the central macular thickness was decreased in the three group after 1 month, 3 months and 6 months of treatment. Compared with the same group before treatment, there were statistically significant differences (P<0.05). The improvement of visual acuity at different time and the increase of Ops wave amplitude were better in group B than group A, better in group C than group B, while the decrease of central macular thickness was greater in group B than group A, greater in group C than group B (all P<0.05). There was no statistically significant difference in the total effective rate among the three groups (P<0.05), but the total effective rate of group C was better than that of group B and group A (P<0.05). Conclusion Epalrestat combined with compound anisodine is effective in the treatment of DR. The combined treatment can significantly improve the visual acuity, relieve macular edema and promote the recovery of retinal function.]]> 2019/4/30 10:20:23 2019/4/30 9:44:31 0.05.In PBL LBL group, the final scores of basic examination, operation skills and case analysis were significantly improved, t were 6.82, 5.78, 8.13, respectively, P<0.05.Compared with LBL group, the final scores of basic examination, operation skills and case analysis in PBL LBL group were significantly higher, t were 4.42, 5.88, 7.10, respectively, P<0.05.The interest and satisfaction of students in PBL LBL group were significantly higher than those in LBL group, z were 2.10, 1.98, respectively, P<0.05.In self-perception assessment of students in PBL LBL group, thepercentages who felt making progress in active learning, communication, teamwork, self-study and problem-solving ability were significantly higher than those in LBL group, χ2were 5.68, 4.44, 4.11, 5.03, 4.29,respectively, P<0.05.Conclusion The combination of PBL and LBL can effectively improve the teaching effect of ophthalmic nursing for higher vocational students and lay a solid foundation for clinical work.]]> 2019/4/30 9:33:10 2019/4/29 14:23:15 2019/4/29 13:38:17 2019/4/29 10:05:18 2019/4/28 16:00:23 0.05). Conclusion: The nasal mucosal incision with the middle turbinate axillary region as the base was associated with more bleeding during the operation, while the nasal mucosal incision with the maxillary line as the base was less bleeding during the operation, and there was no significant difference in the postoperative treatment effect.]]> 2019/4/28 14:51:09 2019/4/28 10:59:24 2019/4/28 10:29:35 0.05). After treatment, the change trend of intraocular pressure was different between the two groups, and the intraocular pressure was more stable in group B (P < 0.05). Six months after treatment, the intraocular pressure in group B was lower than that in group A (P < 0.05), but there was no significant difference in visual acuity, intraocular pressure control rate, the disappearance of neovascularization and the incidence of complications between the two groups (P > 0.05).Conclusion Intravitreal injection of Conbercept combined with Ahmed glaucoma valve implantation and Conbercept combined with trabeculectomy for NVG are safe and effective, but the former is more effective in reducing intraocular pressure and stabilizing intraocular pressure after operation.]]> 2019/4/26 10:41:45 2019/4/26 10:29:01 2019/4/26 10:18:37 2019/4/26 9:39:54 0.05), and compare with 1m after treatment, there was no significant difference between the two groups (P >0.05). During the follow-up period, there were no obvious complications or recurrence observed. Conclusion：Both SML(577 nm) and PDT were effective and safe in the treatment of cCSC, but the theraputic effects of PDT was slightly quicker than SML. Further, with the prolongation of recovery time, the curative effects of these treatments were similar. Additionally, SML(577 nm) costs was much cheaper than PDT and had no risk of injury or allergy for patients,and patients with cCSC could also be treated repeatedly using it. Keywords：Chronic central serous chorioretinopathy;577nm subthreshold micropulse laser; photodynamic therapy;central macular thickness;OCT]]> 2019/4/26 9:28:58 2019/4/24 11:40:18 2019/4/10 13:56:40 2019/4/10 10:05:46 2019/4/9 16:03:29 8.0), group B (28 eyes, OSI ≤ 8.0), and group C (11 eyes, OSI could not be detected due to severe lens opacity).The effect of surgery was predicted by Predicted VA100%　and preoperative BCVA. RESULTS: In group A, 26 eyes (93%) comply with the standard in 28 eyes, and in group B, 24 eyes (86%) comply with the standard in 28 eyes. There was no significant difference between the two groups (P=0.669, P＞0.5). Besides,no correlation was found between PredictedVA100% and postoperative BCVA (r=0.103, P＞0.5). CONCLUSION:The OQASTMⅡ system can objectively, accurately and intuitively predict qualitatively the effect of cataract surgery.]]> 2019/4/8 11:52:21 2019/4/8 10:06:35 0.05), but the visual quality of SMART group was better than that of TransPRK group at 5 days after operation (P < 0.05), and with the prolongation of time, the visual quality of the two groups gradually improved. There was a significant difference in pain scores between the TransPRK group and SMART group (3.56 ±0.96 vs 3.07 ±1.07; 1.22 ±0.61 vs 0.84 ±0.59) on the 1st day and 3rd day after operation (P < 0.01). 5 days after operation, the complete recovery rate of corneal in TransPRK group was lower than that in SMART group (69.2% vs 83.3%, P < 0.05). At 1st and 3 mo after operation, there was no difference in haze between the two groups (5.0% vs 5.0% and 8.3% vs 10.0%) (P > 0.05). Conclusion: There is no significant difference between SMART and TransPRK in the speed and stability of visual acuity recovery, but the early postoperative pain of SMART is lighter, the corneal epithelium is healed faster, and the visual quality is better. Key words: Myopia; Transepithelial photorefractive keratectomy; SmartPulse Technology; double-pass optical quality analysis system]]> 2019/4/4 11:41:33 2019/4/4 11:10:13 2019/4/3 11:50:47 0.05). The average tear film rupture time was significantly lower than that of the non-infected group (P<0.05), and the infection group was significantly lower than the non-infected group (P<0.05). The results of the basic tear secretion test showed that the two groups were based. The amount of tear secretion was lower than the normal level, and the infection group was significantly lower than the control group (P<0.05). The corneal staining score and the meibomian gland secretion function score were significantly lower in the non-infected group than in the infected group (P<0.05). Conclusion: Patients with tarsal gland dysfunction are more likely to have itching, dry and astringent symptoms, eye pain and other symptoms after infection by Demodex, which increases the damage of corneal and conjunctival epithelium. It is of great significance to pay attention to demodex infection test for patients with tarsal gland dysfunction and is worth popularizing.]]> 2019/4/3 11:12:48 0.05), and it was gradually increased in the control group (P<0.05), and the myopic refraction after 1 year of treatment in the observation group was significantly lower than that in the control group (P<0.05); The change value of average annual refraction in the observation group was significantly lower than that in the control group (P<0.05). The best corrected visual acuity (BCVA) after 6mo and 1 year of treatment in the two group was significantly higher than that before treatment (P<0.05), and the BCVA after 1 year of treatment was significantly higher than that after 6mo of treatment (P<0.05), and the difference was statistically significant within-groups at different time points and between-groups after treatment (P<0.05). The difference in the incidence rate of eye redness and swelling between the two groups was not statistically significant (P>0.05), and the recurrence rate of amblyopia after 1year of treatment in observation group was significantly lower than that in control group (2.13% vs 8.89%) (P<0.05). Conclusions Red light flashing therapeutic instrument combined with short-range visual function training for children patients with myopic amblyopia can effectively reduce the change value of average annual refraction, correct the best visual acuity, and reduce the risk of amblyopia recurrence, and it is safe and effective in clinical application.]]> 2019/4/2 13:48:58 2019/4/1 14:16:54 72h, hypoxic-ischemic encephalopathy and mechanical ventilation in non-ROP group and ROP group were statistically significant (P=0.034; p=0.001; p=0.007); However, the significant difference had not been found with other systemic diseases of the premature infants and maternal health during pregnancy between the two groups (P > 0.05). Conclusion The incidence of ROP in Sichuan province is 14.71％. The gestation age, birth weight, oxygen inhalation >72h, hypoxic-ischemic encephalopathy and mechanical ventilation are high risk factors for the occurrence of ROP.]]> 2019/4/1 10:31:32 2019/4/1 10:25:35 0.05). The BCVA of the observation group was significantly better than that of the control group at 3 months after operation (P<0.05). One week after operation, the observation group The thickness of the fovea was lower than that of the control group (P<0.05). There was no significant difference in the thickness of the foveal between the observation group and the control group at 3 months after operation (P>0.05). Before surgery, the two groups of patients The levels of serum VEGF, GAS6 and SDF-1 were not statistically significant (P<0.05). The levels of serum VEGF, GAS6 and SDF-1 in the observation group were lower than those in the control group (P<0.05). The complication rate was 7.14% lower than 26.19% of the control group (P<0.05). Conclusion Intravitreal injection of ranibizumab in patients with proliferative PDR can significantly reduce macular thickness, serum VEGF, GAS6, and SDF-1 levels, improve postoperative visual acuity, and reduce surgical complication rate.]]> 2019/4/1 10:20:41 2019/4/1 10:03:53 2019/4/1 9:54:32 2019/3/29 11:11:21 0.05). The occurrence rate of postoperative hypertension, electric coagulation hemostasis during the surgery, iatrogenic retinal holes, postoperative intraocular tamponade such as silicone oil or gas in the study group was significantly lower than that of the conventional group (χ2=14.249, χ2=32.175, χ2=13.713, χ2=16.338, P<0.05). The thickness of macular center in the study group was significantly lower than that of the conventional group, and the difference was statistically significant (t=2.486, P<0.05). The total incidence of complications in the study group was 5% significantly lower than that of the conventional group (16.67%), and the difference was statistically significant (χ2=4.227, P<0.05). ConclusionRanibizumab assisted 25g vitrectomy ia an effective and safe way to shorten the operation time, ameliorate macular edema, reduce the incidence of postoperative bleeding and complications for PDR patients.]]> 2019/3/29 10:24:15 2019/3/29 10:23:11 2019/3/29 9:41:01 2019/3/28 14:09:37 2019/3/28 14:02:12 2019/3/27 9:49:17 group. All of them were treated with VEC regimen, and the efficacy was evaluated by reference to the efficacy criteria established by the international union against cancer. Indirect ophthalmoscope and ultrasound were used to measure the thickness and diameter of tumor and tumor base before treatment and after 6 courses of treatment, and toxic and side effects were recorded during treatment. Results: The remission rate of the group less than 1 year old was 75.00%, and that of the > group at 1 year old was 92.42%. The difference in remission rate between the two groups was statistically significant (P < 0.05). In the group with less than 1 year old, 5 eyes developed, while in the group with > and 1 eye developed, all eyes underwent enucleation. The mean tumor thickness and mean basal diameter of the remaining eyes were significantly lower than those before treatment, and the difference was statistically significant (P < 0.05). After treatment, the mean tumor thickness and mean basal diameter of the 1-year old > group were less than or equal to that of the 1-year old group, and the difference was statistically significant (P < 0.05). Two groups of children had mild nausea, vomiting and other gastrointestinal symptoms and hair loss, 1 case of mild bone marrow suppression and liver function damage in the group less than 1 year old, 2 cases of mild bone marrow suppression and 1 case of mild liver function damage in the > 1 year old group, there was no statistically significant difference in toxic and side effects between the two groups (P > 0.05). Conclusion: VEC regimen is safe and feasible for the treatment of children in the intraocular phase of Rb, and the efficacy of > is better than that of children less than 1 year old.]]> 2019/3/26 10:33:32 0.05). Conclusion Serum PDGF-BB level was observed to rise with severity of DR and relevant to macula edema. It was also positively correlated to FPG, TG and stages of Diabetes. PDGF-BB could be recommended as diagnostic biomarker for DR.]]> 2019/3/25 10:18:25 0.05), and the safety index in group A was higher than group B, with statistically significant difference (P<0.05). After surgery, the visual acuity in two group was all improved, and the diopter was decreased, and there was no difference between the groups (P>0.05). After surgery, bright, dark without glare and glare contrast sensitivity values in A group was no significant change (P>0.05), bright, dark without glare and glare contrast sensitivity values in group B was all decreased, there were statistically significant differences between groups and groups (P<0.05). complications arise in two group was no statistically significant difference (P>0.05). Conclusion: PPCIOL and femtosecond laser lasik can effectively correct the vision of patients with high myopia, but the effect of PPCIOL on high order aberration and contrast sensitivity is less, and it has more advantages in visual quality after surgery.]]> 2019/3/13 10:22:41 2019/3/12 11:00:30 2019/3/12 10:24:04 0.05). At 3 months after operation, the corneal astigmatism and naked eye visual acuity decreased significantly compared with preoperative, and the corneal astigmatism and naked eye visual acuity were observed in the 3 months after operation. Comparing, P>0.05, IOL axial deviation was compared between 1 day and 3 months after operation, P>0.05; and 3 months after operation and 1 day after operation, P>0.05.Conclusion Toric intraocular lens implantation has a good application value in the treatment of cataract patients with OPD-Scan III labeling method and slit lamp horizontal narrow band labeling method. However, OPD-Scan III labeling method is non-invasive and easy to be used without using sharps. The patient accepted.]]> 2019/3/11 14:09:42 2019/3/11 10:40:35 2019/3/6 13:43:26 2019/3/6 9:09:40 2019/3/5 16:46:52 2019/3/5 9:41:59 2019/3/1 11:15:24 2019/3/1 10:17:13 0.05). The axial length of the eyes in the study group was slightly lower than that in the control group, but the difference was only statistically significant in the 5～6 years age group (P<0.05). Horizontal corneal curvature and vertical corneal curvature were higher in the study group than in the control group (P<0.05). After multiple regression, the equivalent spheroscopy degree =-10.491-0.442*age 0.765*gestational age 5.860*birth weight -1.529*axial axis 0.547*corneal curvature (R2=0.823, P<0.001). Conclusion: the tendency of myopic refractive error and astigmatism in children with low birth weight at the age of 3-6 years is higher than that in children with normal birth weight. The refractive error is closely related to age, gestational age, birth weight, eye axis and corneal curvature, which requires early monitoring and intervention.]]> 2019/2/28 13:43:25 2019/2/28 10:16:48 0.05).The subfoveal choridal thickness(SFCT) of three groups were (338.50±70.44)μm,(357.00±89.16)μm,(319.53±74.37)μm,which was no significant difference (P>0.05).There was a statistically significant difference in nasal choroid thickness between the three groups (P< 0.05). The choridal thickness in nasal area to fovea in the patients with decompensated cirrhosis was increased than that in healthy people(P<0.05). CONCLUSIONS:The choridal thickness in nasal area to fovea in the patients with decompensated cirrhosis is thicker than that in healthy people. There are no significant differences in retinal thickness or retinal volume in macular area between healthy people and patients with liver cirrhosis.]]> 2019/2/28 9:45:33 2019/2/27 9:40:27 0.05). SE and CE at T3 and T4 baselines in the research group were higher than those in the control group (P < 0.05). There were no significant changes in total higher order aberration RMS, vertical coma and horizontal coma in the research group (P > 0.05), but significant increases in higher order aberration such as RMS, spherical aberration, horizontal coma and coma in the control group(P < 0.05). The higher order aberration RMS and coma of T2-T4 in the research group were lower than those in the control group (P < 0.05), while the spherical aberration and horizontal coma of T2-T4 in the study group were lower than those in the control group (P < 0.05). There was no significant change in IOP after operation in the two groups (P > 0.05), but corneal endothelial cell count decreased slightly (P < 0.05).There was no significant difference in IOP and corneal endothelial cell count between the two groups (P > 0.05). Conclusion: ICL V4c implantation is effective, safe and stable in the correction of moderate and high myopia, and has little effect on high order aberration.]]> 2019/2/26 14:55:54 2019/2/25 15:19:35 0.05). None of subjects developed cataract, glaucoma and decompensation of corneal endothelium. The degree of postoperative satisfaction was 100%. Conclusion ICL V4c implantation is a safe and effective method for the correction of high myopia. The visual acuity stabilized 1month after operation..]]> 2019/2/22 9:23:20 2019/1/25 11:59:27 2019/1/23 9:11:23 2019/1/17 10:58:12 0.05). Conclusions There was no effect in the balance function between the improvement of the visual acuity on dominant eye and the non-dominant eye in the age-related cataract with a three months follow-up.]]> 2019/1/17 10:45:34 2019/1/17 9:48:02 2018/12/25 9:25:55