RESULTS: The pooled odds ratio values and 95% CI of age(≥70), diabetes, vitreous overflow, operative time(≥10min), common operating room and control of using time of topical anesthetic were 1.81(95% CI: 1.43-1.69),3.66(95% CI: 1.64-8.16),2.21(95% CI: 1.46-3.32),3.54(95% CI: 2.47-5.06),2.77(95% CI: 2.07-3.72),2.09(95% CI: 1.53-2.86).

CONCLUSION: The main risk factors of endophthalmitis were the age(≥70), diabetes, vitreous overflow, operative time(≥10min), common operating room and control of using time of topical anesthetic.]]> 2016/6/29 17:05:28 Fei Wen, Bin Li and Fa-Wen Li 80true METHODS: We performed a comprehensive search for studies reporting vitreous surgery with intraocular implants randomized controlled and a retrospective controlled clinical trials from China Hownet(CNKI), Wanfang database, and VIP literature database. Studies obtained from those database were filtered according to the criteria, and data were retrieved from eligible studies for further analysis. Then we performed a meta-analysis to evaluate the efficacy and safety of intraocular implants using comprehensive Meta-analysis software version 2(Biostat, Englewood, NJ).

RESULTS: In total 36 studies were recruited for our Meta-analysis, including 5 092 cases. Meta analysis showed: 1)regarding the efficacy of repairing the retinal detachment, silicone oil was a better intraocular implants than C₃F₈(OR=1.76; 95% CI: 1.19-2.60, P=0.0047)and SF₆(OR= 4.68; 95% CI: 1.48-14.81, P=0.0087); 2)regarding the risk of postoperative cataract, silicone oil showed significant higher risk than BBS(OR=3.24; 95% CI: 2.10-4.99, P=1.09 e-7), and C₃F₈(OR=3.03; 95% CI: 1.50-6.10, P=0.0019); 3)regarding the risk of postoperative intraocular pressure, silicone oil showed significant higher risk than BBS(OR=6.74; 95% CI: 3.38-13.41, P=5.67 e-08), and C₃F₈ also showed a higher risk than BBS(OR=4.79; 95% CI: 2.37-9.68, P=1.29 e-05). In addition, silicone oil showed significant lower risk as compared with heavy silicone oil(OR=0.16; 95% CI: 0.08-0.53, P=0.0026).

CONCLUSION: The intraocular implants for the treatment of retinal detachment in vitreous retinal surgery are mainly divided into two major categories, liquid and gas implants. The silicone oil, a major liquid implant, shows higher efficacy in terms of treating retinal detachment than the gas implants. However, the silicone oil is associated with a higher risk of postoperative cataract and intraocular pressure as compared with gas implants.]]> 2016/6/29 17:05:28 Ren-Liang Huang, Xue-Lai Li and Xian-Hua Chen 79true METHODS: Such databases as PubMed(1980-Sep 2015),CBM(1990-Sep 2015),VIP(1989-Sep 2015),CNKI(1990-Sep 2015)and WanFang Data(1990-Sep 2015)were searched to collect the randomized controlled trials(RCTs)about AcrySof 3-piece IOL vs Sensar 3-piece IOL for PCO or incidence of Nd:YAG laser capsulotomy.According to the inclusion and exclusion criteria,two reviewers independently screened the literatures,extracted data and assessed the quality of the included studies,then Meta-analysis was conducted using RevMan 5.2 software.

RESULTS: A total of 5 RCTs involving 1 036 eyes(AcrySof group: 553 eyes, Sensar group: 483 eyes)were included, with a follow-up duration of 6mo～2a.The results of Meta-analysis showed that:(1)the incidence of PCO was significantly lower in AcrySof group than that in Sensar group(OR=0.67,95%CI:0.45～0.99,P=0.04);(2)the incidence of Nd:YAG laser capsulotomy after surgeries was similar between AcrySof group and Sensar group(OR=0.57,95%CI:0.32～1.02,P=0.06);(3)in an above 2a long-term follow-up subgroup analysis, AcrySof group indicated a significantly lower incidence of PCO(OR=0.60,95%CI:0.40～0.91,P=0.02), while the Nd:YAG laser capsulotomy incidence was similar between the two groups(OR=0.60,95%CI:0.33～1.09,P=0.09).

CONCLUSION: AcrySof 3-piece IOL seems to have a stronger preventive effect on PCO than Sensar 3-piece IOL. For the quantity limitation of the included studies,this conclusion still needs to be further proved by more high-quality RCTs.]]> 2016/3/28 15:32:19 Yi Zhu,Dai Li,Si-Cong Wang,Jing Yuan and Xiao-Jun Cai 78true METHODS: Such databases as PubMed, EMbase, CBM, CNKI, VIP, and WanFang Data were searched. The retrieval time was from inception to September 2015, and the language was in both Chinese and English. After extracted the data and assessed the quality of the included studies, the Meta-analysis was performed by using RevMan 5.3 software.

RESULTS: A total of 6 studies involving 909 eyes were included. The results of Meta-analysis showed that, compared with that before wearing orthokeratology, the visual acuity improved in orthokeratology group at 1wk, 1, 3, 6mo and 1a \〖1wk: MD=-0.34, 95%CI(-0.55, -0.14), P=0.001; 1mo: MD=-0.50, 95%CI(-0.69, -0.30), P<0.01; 3mo: MD=-0.54, 95%CI(-0.70, -0.37), P<0.01; 6mo: MD=-0.49, 95%CI(-0.50, -0.47), P<0.01; 1a: MD=-0.46, 95%CI(-0.64, -0.29), P<0.01\〗. After wearing orthokeratology 1a, diopter also be effectively controlled \.

CONCLUSION: Orthokeratology is an effective control method to correct high myopia and high myopia development. But further studies are still required for its long-term effect.]]> 2016/3/28 15:32:20 Yang-Yang Wu 77true METHODS:The results of 17 studies on the main risk factors of cataract were analyzed by Meta-analysis method.

RESULTS:The pooled odds ratio values and 95%CI of age, hypertension, diabetes, smoking, presence of merging other eye diseases and long-term exposure to sunlight were 2.48(1.82～3.36),1.88(1.28～2.75),3.55(2.41～5.24),2.58(1.45～4.56),2.39(1.50～3.82),1.82(1.08～3.06).

CONCLUSION:The main risk factors of cataract were age, hypertension, diabetes, smoking, presence of merging other eye diseases and long-term exposure to sunlight.]]> 2016/3/2 8:19:50 Fei Wen,Bin Li,Fa-Wen Li and Mei Li 76true METHODS: Databases including PubMed, CBM, CNKI, VIP and WanFang Data were electronically searched for all randomized controlled trials(RCTs)about comparing the efficacy and safety between bevacizumab and MMC in augmenting trabeculectomy for glaucoma before the date of Jun.2016. Two reviewers independently screened literatures according to the inclusion and exclusion criteria, and evaluated the included studies. Then, Meta-analysis was performed.

RESULTS: A total 4 RCT involving 286 eyes(143 for bevacizumab group, 143 for MMC group)were included. The results of Meta-analysis showed that there was no significant difference between bevacizumab and MMC in the last follow-up after surgery in IOP(WMD=2.21, 95%CI: -0.17 to 4.58, P=0.07), complete success rate(OR=0.69, 95%CI: 0.26 to 1.81, P=0.45)and the numbers of anti-glaucoma medicine(OR=0.12, 95%CI: -0.15 to 0.39,P=0.39). And there was no significant difference between bevacizumab and MMC in postoperative complications:hypotony(OR=0.7, 95%CI: 0.12 to 4.05,P=0.69), bleb leak(OR=1, 95%CI: 0.21 to 4.74,P=1), encapsulated bleb(OR=1.15, 95%CI: 0.38 to 3.44, P=0.81), choroidal detachment(OR=1.22, 95%CI: 0.29 to 5.22, P=0.78)and cataract(OR=1.15, 95%CI: 0.38 to 3.44, P=0.81).

CONCLUSION: Bevacizumab and MMC in augmenting trabeculectomy for glaucoma have similar efficacy and safety. Bevacizumab can't result in better outcome in term of IOP reduction. Clinicians should choose suitable solution according to disease characteristics.]]> 2016/10/25 14:35:36 Yue Wang, Min Ke and Wen-Huan Wang 75true METHODS: A Meta-analysis. A comprehensive retrieval was conducted using the database including EMbase, the Cochrane Library, Pubmed, CBM, WanFang Database, CNKI and so on. The retrieval time was limited from the building time of database to Jan. 2017. The randomized controlled trial was adopted with no requirements on languages. The Jadad scale and Cochrance cooperation were used as the tool of the risk and bias evaluation to analyze the literature quality. Quality estimation of evidence-based medicine on the parameters of each evaluation index was made via GRADEpro Software. The publishing biases of enclosed documents were inspected with funnel plot. At last, the Meta analysis was conducted with Review Manager 5.3.

RESULTS: Totally 16 literatures published from 2008-2016 were finally put into randomized controlled trial. A total of 923 cases were included, among which 493 cases were grouped as intravitreal injection of anti-VEGF before the combined operation of PPV group(the experimental group), and 430 cases were involved in simple PPV group(the control group). The results of Meta-analysis show:(1)The probability of intraoperative bleeding was remarkably lower than the control group \〖OR=0.06, 95%CI(0.02, 0.15), P<0.01\〗, with statistically significant differences.(2)The duration of operation was obviously shorter than that of the control group\〖WMD=-29.13, 95% CI(-36.95, -21.30), P<0.01\〗, with statistically significant differences.(3)The probabilities of both early and late postoperative vitreous hemorrhage were lower than those of the control group\〖OR=0.34, 95%CI(0.20, 0.58), P<0.01\〗, with highly statistically significant differences.(4)The best corrected visual acuity after surgery was no better than that of the control group, \〖WMD=-0.51(LogMAR), 95%CI(-1.10, 0.08), P=0.09\〗 with no statistical significance.(5)The occurrence of iatrogenic retinal rupture was lower than that of the control group\〖OR=0.24, 95%CI(0.14, 0.40), P<0.01\〗, with statistically significant differences.(6)Among the 493 patients included in the 16 literature, no case of ocular and general adverse effects due to anti-VEGF injections was reported.

CONCLUSION: It is effective and safe for the patients with proliferative diabetic retinopathy to inject anti-VEGF drugs into vitreous cavity before vitrectomy. And it can reduce the occurrence of complications during and after surgery, improving the general treatment effects. However, the specific implementation plans, such as the injection does, the interval between the injection and the operation and so on, still need further exploration and perfection.]]> 2017/7/24 10:38:38 Jun Li and Guo-Xing Xu 74true METHODS: We performed a comprehensive search for the randomized controlled trials(RCTs)about the olopatadine eye drops and other therapies vs. olopatadine eye drops monotherapy for treating allergic conjunctivitis published by April, 2016 from PubMed, EMbase, Cochrane Library, VIP Chinese periodical Database, CNKI and Wan Fang Chinese periodical Database. Studies obtained from eligible database were filtered according to the criteria, and data were retrieved from those studies for further analysis. Then we performed a Meta-analysis using RevMan 5.3 software.

RESULTS: A total of 28 RCTs were included. Among all 3568 patients involved in, 1 799 were in the treatment group, while the other 1 769 were in the control group. The results of Meta-analysis showed that the olopatadine eye drops and other therapies was superior to monotherapy for patients with allergic conjunctivitis in clinical effects \〖OR=3.54,95%CI(2.71,4.61),P<0.001\〗.

CONCLUSION: The existing evidence supports that the prognosis of the olopatadine eye drops and other therapies is better than olopatadine eye drops monotherapy for treating allergic conjunctivitis. For the quality and quantity limitations of the included studies, more well-designed and double blind RCTs are required to further prove this conclusion.]]> 2017/1/20 0:00:00 Jian Zhang and Yi-Lin Yang 73true METHODS:The PubMed, Cochrane Library, SciVerse, WanFang Data and CNKI databases were searched for Meta-analysis of literature comparing FS-LASIK and SMILE outcomes.

RESULTS:A total of 5 literatures met the inclusion criteria of this study, a total of 689 cases(999 eyes). Meta-analysis showed: SMILE and FS-LASEK myopia treatment effectiveness \〖OR=0.83, 95%CI=(0.52, 1.33)\〗, predictability \〖OR=0.54, 95%CI=(0.22, 1.29)\〗 and security \〖OR=1.10, 95%CI(0.80, 1.51)\〗 no statistically significant difference.

CONCLUSION:SMILE and FS-LASIK correction of myopia is safe, effective, have good vision correction effect. However, due to the low quality of the included studies and the instability of the statistical results, the above conclusions need to be further validated by more rigorous randomized controlled trials.]]> 2016/12/21 10:42:29 Shan Liu and Xiang-Long Yi 72true METHODS:We searched Pubmed, EMBASE, Cochrane Library Central Register of Controlled Trials(CENTRAL), Google scholar, ClinicalTrials.gov, CNKI, VIP and wanfang database for studies which published between January 1 2012 and July 1 2017, on the comparison of conbercept with ranibizumab for the clinical effect of secondary macular edema. The primary endpoints were visual acuity(VA)and central macular thickness in this study to assess the efficiency of the drugs. Review Manager 5.3 and Stata 12.0 were used for data analysis with the pooled odds ratios(OR), mean difference and 95% confidence interval(CI).

RESULTS: Eleven RCTs involving 812 patients met inclusion criteria and included in this meta-analysis, including 414 eyes in conbercept group and 398 eyes in ranibizumab group. Macular edema in this study were secondary to age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. No significant differences in improvement of vision acuity(P=0.09)or reduction of CMT(P>0.05)were noted at the end of 3mo between two groups. Compared to ranibizumab, conbercept showed a better effectiveness in macular edema alleviation in the end of 6mo in the present study(OR=-58.50, 95%CI: -108.04 to -8.95; P=0.02).

CONCLUSION: Despite evidence from the meta-analysis of the RCTs suggesting a strong difference of the effectiveness for macular edema between conbercept and ranibizumab, more clinical trials are still needed to confirm our results because of the heterogeneity in the collected data.]]> 2017/11/20 16:09:09 Rui Shi, Le Yang, Yun Qi, Feng Wang, Hai-Yan Zhou and Yu-Shun Xue 71true METHODS: The Cochrane Library, PubMed, BMC, National Knowledge Infrastructure(CNKI), and VIP databases were searched to identify the clinical randomized controlled trials of comparing effects of NSAIDs administered at different time points on the incidence of CME and the central foveal thickness following phacoemulsification. The experiment group received topical NSAIDs preoperatively and postoperatively, while the control group received topical NSAIDs postoperatively. The RevMan software 5.2 and Stata software 12.0 were used in the Meta-analysis.

RESULTS: Six studies were included in this Meta-analysis. No statistically differences were observed in the incidence of CME after 1wk postoperatively(OR=1.58, 95%CI: 0.48-5.18, P>0.05), in the incidence of CME after 1mo postoperatively(OR=0.78, 95%CI: 0.30-2.00, P>0.05), in the central foveal thickness after 1wk postoperatively(WMD=-7.20, 95%CI: -15.17 to 0.77, P>0.05), and in the central foveal thickness after 1mo postoperatively(WMD=-3.98, 95%CI: -14.05 to 6.08, P>0.05). However, statistically significant differences were found in the incidence of CME after 3mo postoperatively (OR=0.22, 95%CI: 0.11-0.43, P<0.01)and in the central foveal thickness after 3mo postoperatively(WMD=-18.25, 95%CI: -33.80 to -2.70, P<0.05).

CONCLUSION: A combination of NSAIDs administrated preoperatively and postoperatively can reduce the incidence of the CME and the thickness of the macular centrall. Thereby, the effects of administrating NSAIDs both preoperatively and postoperatively have more advantages than that of administrating NSAIDs postoperatively alone.]]> 2017/10/19 16:49:01 Li-Jun Wang, Yi Zhang, Xiao Xiao, Lin Zhao and Jian-Ming Wang 70true METHODS: We searched in Pubmed, Medline, Embase, Elsevier, Cochrane Library, Wangfang database, CNKI, VIP database, Sinomed database, and gray literature were performing manual. The efficiency, intraocular pressure, adverse reactions and extract valid data were evaluated.

RESULTS: Totally 8 controlled trials were enrolled, including 970 patients. Compared with control groups, the efficiency and the intraocular pressure in experiment group had a statistically significant increase(RR=1.75, 95%CI=1.29-2.37, P=0.0003; SMD=1.30, 95%CI=0.85-1.75, P<0.00001), and there was no statistic difference in adverse reactions(RR=1.64, 95%CI=0.86-3.10, P=0.13).

CONCLUSION: Tobramycin and dexamethasone ointment in treatment of blepharitis is effective with no adverse effects. Due to the quality of the literature is low, there is still need high quality randomized controlled trials.]]> 2017/10/19 16:49:01 Lan Ke and Yan-Ning Yang 69true METHODS: Databases including CNKI, CBM, WangFang, VIP, Medline, EMBASE, Cochrane library were searched to collect randomized controlled trails(RCTs)about phacoemulsification combined with intraocular lens implantation versus trabeculectomy. Cochrane collaboration's tool were used to assess the risk of bias of included studies and the meta-analysis was conducted by Revman 5.3 software.

RESULTS: Nine eligible studies involving 696 patients were included. The results of meta-analysis shows that: there were no significant differences between two groups in postoperative intraocular pressure(P>0.05). While phacoemulsification combined with intraocular lens implantation has lower complications rate(Z=4.32, P<0.0001).

CONCLUSION: Current evidence shows that phacoemulsification combined with intraocular lens implantation and trabeculectomy may has the similar efficacy for angle-closure glaucoma with cataract. But the former operation are more safer for patients.]]> 2018/8/17 17:07:07 Jin-Hua Wang, Fan-Fan Su, Qiao Chen, Yao Chen and Zhi-Qin Wu 68true METHODS: All randomized controlled trials(RCTs)of ganciclovir combined with TCM for HSK were searched in CNKI, VIP, Wanfang, PubMed, Cochrane Library and EMbase database. The clinical endpoints of the total effective rate, relapse rate, heal time, and adverse reaction rate were collected to assess the drugs' efficacy and safety. The improved Jadad Scale was used to evaluate the methodological quality of included literatures. The RevMan5.3 software and Stata 12.0 were applied for meta-analysis.

RESULTS: We finally included 15 RCTs involving 1 285 patients. As for the total effective rate, relapse rate and heal time, significant differences were noted between ganciclovir combined with TCM group and ganciclovir alone group. For the total effective rate, RR and 95%CI were 1.23(1.15～1.31)according to the number of patients and 1.18(1.02-1.38)according to the number of diseased eyes. For relapse rate, RR and 95%CI were 0.25(0.17-0.36). For heal time, MD and 95%CI were -7.58(-10.89 to -4.26). No statistic difference of adverse reaction rate between the two groups was observed \〖RR=0.53, 95%CI(0.23-1.22)\〗. The side effects in the two groups were mild and could be relieved by themselves.

CONCLUSION: The ganciclovir combined with TCM can improve the total efficacy, reduce the relapse rate, and shorten the course of treatment for HSK with good safety.]]> 2018/6/27 10:52:30 Xiu-Wen Zhang, Ling Li, Feng-Jiao Bu and Nian-Zu Chen 67true METHODS: According to the Cochrane evaluation system method, we searched Medline(January 2013 to October 2017), EMbase(2013-2017), Cochrane Library(2017), Wanfang database(2013-2017), VIP(2013-2017), and CNKI(2013-2017)for studies published. We included randomized controlled trials conducted the TCM in the treatment of dry eye. RevMan 5.0 statistical software data extraction and Meta analysis were conducted.

RESULTS: A total of 10 studies were identified, nine were from Chinese literature and one was from English literature, of which including 1 229 eyes. Nine of these studies performed BUT measurements at the end of the course of treatment. The results showed a statistically significant difference(P<0.00001). Nine studies performed tear flow measurements at the end of the course of treatment and the results showed a statistically significant difference(P<0.0001). Two studies performed FL measurements after the end of the course of treatment; the results showed no statistically significant difference(P=0.25). Three studies performed dry eye symptoms after the end of the course of treatment; the results showed that the differences were statistically significant(P=0.0003); the overall efficacy comparison, the difference between the two groups was statistically significant(P<0.00001).

CONCLUSION: TCM treatment can significantly prolong BUT and increase tear flow, and has more advantages in the treatment of dry eye.]]> 2018/5/25 15:46:39 Peng-Fei Jiang, Jun Peng, Ya-Sha Zhou, Xiao-Fang Peng, Xiang Li, Yi-Chen Li, Qing-Hua Peng and Xiang-Dong Chen 66true METHODS:We performed a comprehensive search for the randomized controlled trials(RCTs)about conbercept trail group vs control group in the treatment of eAMD published by November, 2017 from PubMed, Cochrane Library, CNKI and Wanfang Database. Studies obtained from eligible database were filtered according to modified Jadad scale, and data were retrieved from those studies for further analysis. Then, we performed a Meta-analysis using RevMan 5.3 and Stata 12.0 statistical software.

RESULTS:A total of 12 RCTs were included, involving 924 patients. The results of Meta-analysis showed that the central macular retinal thickness(CMT)markedly decreased at 1, 3, 6 and 12mo after treatment; visual acuity at 3 and 6mo and quality of life(QOL)at 6mo were significantly improved; total effective rate of treatment at increased, which was statistically different to control group(P<0.05), but rate of adverse reaction was similar(P>0.05). The long-term effect was better than control group.

CONCLUSION:The existing evidence supports that conbercept has good therapeutic efficacy and safety for eAMD. It can significantly reduce the CMT, improve the visual acuity, the quality of life and the total efficiency of treatment, and the long-term effect is better than control group.]]> 2018/5/25 15:46:39 Chun-Xing Li and Hua Liu 65true METHODS: We collected randomized controlled trials from CNKI, CBM, Wanfang database, PubMed, EMBASE and Cochrane Library in 2000-2015, and the improved Jadad scale was used to evaluate the methodology of the literature, and the data was extracted. The Review Manager 5.3 statistical software was used for meta analysis.

RESULTS: A total of 5 articles were included in the analysis, with a total sample size of 836 cases. The curative effect of experimental group on pseudomyopia was better than that of control group, and the differences are statistically significant(Z=6.39, P<0.01).

CONCLUSION: Compared with topiramine eye drops alone, combined with traditional Chinese medicine therapy for treating pseudomyopia in children and adolescent is more effective, and is safe and reliable.]]> 2018/4/24 14:27:16 Dan Li, Ling Shen and En-Li Deng 64true METHODS: Seven databases, including the Cochrane Library, Medline, EMbase, CBM, CNKI, VIP, and WanFang Data, were searched. The published languages were limited to English and Chinese. The risk bias tool provided by Cochrance cooperation and methodological index for non-randomized studies(MINORS)scale were used to assess the risk bias of included studies(randomized controlled trials and controlled trials). The published biases of included studies were assessed with funnel plot. Meta-analysis was performed with Review Manager 5.3.

RESULTS: Seven eligible studies, including 478 children, were included, 250 cases in ortho-k group, 228 cases in control group. The Meta-analysis indicated that change in axial length of ortho-k group was significantly less than the control group \〖WMD=-0.31, 95%CI(-0.35, -0.26), P<0.001\〗. Five studies observed adverse effects which all included the effect of positive staining of corneal fluorescein. One study reported chalazion in one child. None of the studies reported severe adverse events.

CONCLUSION: The overall findings suggested that orthokeratology might slow the progression of myopia in children of Asia.]]> 2018/1/19 9:47:42 Zuo-Jie Zhang, Zhi-Qiang Hu, Min Shu, Ling-Li Zhang and Ke Lan 63true METHODS:We performed a comprehensive search via Pubmed, Embase, Cochrane Library, VIP Chinese Science and Technology Journal Database, CNKI and Wan Fang Chinese periodical Database for the randomized controlled trials(RCTs)at home and abroad about effects of the domestic deproteinized calf blood extract eye gel for corneal epithelial repair after laser corneal refractive surgery with retrieval time from January 2007 to December 2016. According to the inclusion and exclusion criteria, 2 medical researchers independently screened documents, extracted data and evaluated the quality. Review Manager 5.3 software was used for Meta analysis.

RESULTS: Seven RCTs involving 1 042 eyes, including 523 eyes in the treatment group and 519 eyes in the control group, were selected for this Meta-analysis. The results showed that the clinical efficacy in the treatment group was better than that in the control group(OR=1.81, 95%CI: 1.39～2.35; P<0.001). And the corneal injury symptom score in the treatment group was superior to that in the control group(WMD=-0.33, 95%CI: -0.45 to -0.21; P<0.001). And the corneal healing time in the treatment group was shorter than that in the control group(WMD=-1.26, 95%CI: -1.56 to -0.97; P<0.001).

CONCLUSION: The domestic deproteinized calf blood extract eye gel can relieve the patients' symptoms after laser refractive surgery, improve the corneal epithelial recovery and the efficiency of treatment. Due to the limited quality and quantity of the studies these conclusions should be further validated by more well-designed randomized double blind controlled trials.]]> 2017/12/18 10:32:19 Jian Zhang, Yi-Lin Yang and Hai-Fan Huang 62true METHODS:We performed a comprehensive search for the randomized controlled trials(RCTs)about Conbercept trail group vs control group in the treatment of DR published from PubMed, Cochrane Library, CNKI and Wanfang Database. Studies obtained from eligible database were filtered according to modified Jadad scale, and data were retrieved from those studies for further analysis. Then, we performed a Meta analysis using RevMan 5.3 statistical software.

RESULTS:A total of 22 RCTs were included, involving 1 878 patients. The results of Meta-analysis showed that visual acuity at 1 and 3mo, the central macular retinal thickness(CMT), operation time, the level of vascular endothelial growth factor(VEGF)and the implicit time of N1 wave were markedly decreased after treatment; the scores of self-care ability, social ability, activity ability, and psychological ability and response rates after treatment were significantly improved; and which were statistically different to control group. As for safety, the incidences of anterior chamber inflammation reaction, corneal edema, ocular hypertension, bleeding in operation, vitreous hemorrhage, iatrogenic visual hiatus and retinal detachment, complication incidence were more significantly decreased than control group. The same results were gained in subgroup.

CONCLUSION:The existing evidence supports that conbercept has good therapeutic efficacy and safety for DR.]]> 2018/9/14 16:29:45 Chun-Xing Li and Hua Liu 61true METHODS: Comprehensive computer search database according to Cochrane systematic evaluation method. Randomized controlled trials of glaucoma after NGF treatment in the past 5a were included, the data extraction and Meta-analysis were performed by using Revman 5.3 statistical software.

RESULTS: A total of 6 cases randomized controlled trials were included, all of which were in Chinese, totally 513 cases. At the end of the treatment period, visual acuity was detected in 5 of the studies and 6 studies were performed with intraocular pressure, the difference among cases and normal were not statistically significant \〖MD=0.10,95%CI(-0.05,0.25),P=0.19; MD= -0.90, 95%CI (-1.92, 0.11), P=0.08\〗; 5 studies were performed on the visual field and 3 studies performed visual evoked potential(VEP), included P100 wave latency and P100 wave amplitude, the difference was statistically significant \〖MD= -2.49, 95%CI (-4.02, -0.96), P=0.001; MD= -12.13, 95%CI (-17.30, -6.97), P<0.001; MD=1.34, 95%CI (0.93, 1.74), P<0.001\〗.

CONCLUSION: NGF can improve the visual field of patients with glaucoma, and also can improve image visual evoked potential P100 wave latency and P100 wave amplitude. However, the effect of improving visual acuity and reducing intraocular pressure is not obvious. In a word, the NGF can ameliorate the optic neuropathy.]]> 2019/8/23 9:51:22 Hui-Yu Qin, Qing-Hua Peng, Chen Ou and Peng-Fei Jiang 60true METHODS: Found a randomized controlled trial for the treatment of xerophthalmia with Thunder-Fire Moxibustion and massage acupoints around eyes by the retrieval from Pubmed, Embase, Cochrane Library, China Science and Technology Journal Database, CNKI and Wanfang Data. After two researchers independently screened the literature, extracted the data and evaluated the quality according to the inclusion and exclusion criteria, Review Manager 5.3 was applied to process Meta-analysis.

RESULTS: Finally, seven RCT were selected for this Meta-analysis, a total of 530 patients,including 265 patients in the treatment group and 265 patients in the control group. The results showed that the clinical efficacy in the treatment group was better than that in the control group(OR=2.44, 95% CI: 1.74-3.43; P<0.001). And the SⅠt in the treatment group was superior to that in the control group(WMD = 0.87, 95% CI: 0.46-1.27; P<0.001). And the BUT in the treatment group was longer than that in the control group(WMD= 1.44, 95% CI: 1.01-1.86; P<0.001).

CONCLUSION: Thunder-Fire Moxibustion and massage acupoints around eyes can improve the SⅠt and BUT of xerophthalmia. The therapy is not only safe and effective, but suitable for wider use as well.]]> 2019/7/25 14:32:57 Lei Zhao, Tao Zuo, Fang-Yuan Wang and Kai-Yao Chi 59true METHODS:The literature was retrieved from China Knowledge Network(CNKI), VIP, Wanfang Database, PubMed, EMbase, Cochrane Library, European PMC, and Natural database. The search time was built until September 2018. The 6-month follow-up time was used to observe the macular hole closure, primary retinal detachment and BCVA. Meta-analysis was performed using Review 5.3 and Stata 15.1 software.

RESULTS: In this study, a comparative analysis of 266 eyes in 8 studies was included. Statistically, the effect of ILM reversal tamponade in the macular hole closure rate is better than ILM stripping, the difference was statistically significant(RR=2.05, 95% CI 1.69 to 2.49, P<0.00001), there was no statistically significant difference in the efficacy of primary retinal detachment rate(RR=1.04, 95% CI 0.98 to 1.12, P=0.21), the BCVA of the two groups was significantly higher than that before surgery at 6mo after surgery, the difference was statistically significant(RR=0.44, 95% CI 0.33 to 0.55, P<0.00001; RR=0.29, 95% CI 0.10 to 0.48, P=0.003). The results of the extent of BCVA improvement between the two groups are heterogeneous, and the conclusions may be unstable, and more reliable data are needed.

CONCLUSION: PPV+ ILM flap insertion is more effective in treating patients with high myopia macular hole retinal detachment.]]> 2019/3/22 14:50:41 Zhi-Hua Huang, Wei Tan, Ying Zhang and Yue-Ling Cui 58true METHODS: Search literatures in PubMed, Web of Science, Cochrane library, OVID, Chinese biomedical literature database, Weipu, Wanfang and CNKI database from the establishment of the database to May 30, 2018. The main contents included randomized controlled trials and cohort studies about comparing the postoperative complications of orbital blowout fracture through the transconjunctival approach and subciliary approach. Meta-analysis of the incidence of complications was performed using Review Manager 5.3 statistical software.

RESULTS: A total of 7 cohort studies were included. The Newcastle Ottawa Scale(NOS)score showed that the quality of the included literature was above 6 points. Meta-analysis showed no significant difference in odds ratio(OR)between the transconjunctival approach group and subciliary approach group \〖OR=0.74, 95% CI (0.44-1.24), P=0.25\〗. Sensitivity analysis showed that the results of the Meta-analysis were stable and reliable. Funnel plot analysis showed that there might be publication bias in the included literature.

CONCLUSION: The effect of skin approach and conjunctival approach on the incidence of postoperative complications of orbital blowout fractures is not significant. The two approaches have their own advantages and disadvantages. It is necessary to combine the clinical practical considerations to select the most suitable surgical approach.]]> 2019/3/22 14:50:41 Jin-Hai Yu, Hong-Fei Liao, Hao Luo, Meng-Lin Shi and Qi-Hua Xu 57true METHODS: According to the Cochrane systematic review method, the computer searched Medline, EMbase, Cochrane Library, Wanfang database, Weipu database, China Knowledge Network database, and included in the randomized controlled study of pranoprofen combined with sodium hyaluronate in the treatment of dry eye in 2014-2018, RevMan5.3 statistical software for data extraction and Meta-analysis.

RESULTS: A total of 8 randomized controlled trials, all in Chinese, totally 1 008 patients. Meta-analysis showed that compared with the use of sodium hyaluronate alone, prano fraction combined with sodium hyaluronate significantly improved the BUT, SⅠt, FL, dry eye symptoms and overall efficacy of the patients, the difference was statistically significant.

CONCLUSION: The efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye was better than that of sodium hyaluronate alone.]]> 2019/1/17 14:38:59 Peng-Fei Jiang, Qing-Hua Peng and Jun Peng 56true METHODS:A literature review using the MEDLINE, EMBASE, The Cochrane Library, Web of Science, Clinical Trial, CBM, Wanfang Databases and paper collections of conferences was performed. Randomized controlled trials comparing the effects of BLR and R & R for basic intermittent exotropia with a duration of follow-up at least half a year were eligible for inclusion. The methodologic quality of included studies was evaluated independently by 2 authors. Statistical analysis was performed by using the STATA 14 software(StataCorp Texas USA).

RESULTS:Five prospective random controlled clinical trials involving 529 patients were included. Compared with R & R procedure,the BLR procedure group showed lower successful rate(RR:0.85; 95% CI:0.72-0.99; P=0.043)and postoperative undercorrection(RR:3.975; 95% CI:2.097-7.537; P<0.01). The P value of long-term postoperative corrected rate in Meta analysis was decreased near to 0.05 when the included references increased. There was no significant difference in overcorrection rate between the BLR and R & R procedures(RR:0.336; 95% CI:0.049-2.294; P=0.266).

CONCLUSION:Current evidences suggested that BLR procedure is related to lower successful and higher undercorrection rates for basic intermittent exotropia compared to conventional R & R procedure.]]> 2018/12/17 9:54:35 Ya-Tu Guo, Lu Tian and Wei Zhang 55true METHODS: Computerised search was conducted to retrieve studies from PubMed, CBM, WanFang Data, VIP, and CNKI databases, from the establishment of the databases to April 2019. The search yieldedrelevant studies on the use of orthokeratology to control the development of myopia in teenage patients. After two researchers independently conducted literature screening, data extraction, and methodological quality evaluation, a Meta-analysis was performed using RevMan 5.3 software.

RESULTS: Finally, 8 relevant studies were selected, which included 1 136 teenage patients with myopia. The Meta-analysis revealed that after wearing orthokeratology lens for 1wk, keratometry results changed without statistical significance \〖1wk: MD=0.91, 95% CI(-0.01-1.83), P=0.05\〗. However, after using orthokeratology lens for 1, 3, 6, and 12mo, keratometry results decreased \〖1mo: MD=0.82, 95% CI(0.12-1.53), P=0.02; 3mo: MD=1.31, 95% CI(0.63-2.00), P<0.05; 6mo: MD=1.35, 95% CI(0.62-2.09), P<0.05; 12mo: MD=1.41, 95% CI(0.68-2.41), P<0.05\〗. Further, after 12mo of using orthokeratology lens, the increase in dioptre was effectively controlled \〖12mo: MD=2.61, 95% CI(1.52-3.71), P<0.05\〗, and the uncorrected visual acuity improved \〖12mo: MD=-0.81, 95% CI(-0.84--0.79), P<0.05). The ocular axis did not show a statistically significant increase \〖12mo: MD=-0.06, 95% CI(-0.21-0.09), P=0.44\〗.

CONCLUSION: The use of orthokeratology lens cannot only reducekeratometry values, but also control the growth of the ocular axis. However, these results can be achieved only after long-term wear.]]> 2019/10/23 0:00:00 Sha Liu, Jing Dong and Bin Wang 54true METHODS:According to the Cochrane systematic review method, we searched three databases(Pubmed, Web of Knowledge and CNKI). The change of intraocular pressure was used to assess the effect of ripasudil, WMD with 95% confidence intervals(CI)were used to report the outcome. Subgroup analysis was performed according to different types of glaucoma.

RESULTS:A total of 9 trials all in English, totally 3446 patients, Meta-analysis showed that compared with before-treated groups, after-treated groups have significant lower IOP(Test of WMD= -2.96 95% CI: -3.48 to -2.45, P<0.001), which indicates that ripasudil has great efficacy of curing glaucoma.

CONCLUSION:Ripasudil have significant efficacy in reducing IOP, which can be used as a treatment for glaucoma.]]> 2019/9/20 14:45:20 Lan Ma, Ruo-Lan Qian 53true 99Tc-MDP)with methylprednisolone to treat thyroid-associated ophthalmopathy(TAO).

METHODS: We retrieved from 9 databases, from their foundation to March 2019, including Pubmed, the Cochrane Library, EMbase, ClinicalTrial.gov, Web of Science, CNKl, VIP database, China Biology Medicine disc, Wanfang database and collected the randomized controlled trail(RCT)of ⁹⁹Tc-MDP combined with methylprednisolone for treatment of TAO. According to inclusion and exclusion criteria, two researchers retrieved the literature independently, extracted data and evaluate methodological quality. Meta analysis was performed by Review Manager 5.3 software.

RESULTS: A total of 8 RCTs were identified with 644 patients. There was significant difference in the overall clinical effective rate between ⁹⁹Tc-MDP combined with methylprednisolone and methylprednisolone alone(RR=1.14, 95% CI: 1.03-1.26, P=0.01). Significant difierence was found in the effective rate of proptosis between intravenous injection of ⁹⁹Tc-MDP with methyprednisone and methyprednisone only(RR=1.28, 95% CI: 1.16-1.41, P<0.00001). Meanwhile, great improvement was seen in diplopia(RR=1.64, 95% CI: 1.04-2.58, P=0.03), but there was no significant difference in disturbance of ocular dyskinesia(P=0.37).

CONCLUSION: Applying ⁹⁹Tc-MDP combined with methylprednisolone is better than methylprednisolone alone for TAO with less adverse reaction, which appears to be an effective treatment for TAO.]]> 2019/9/20 14:45:20 Ya-Ru Du and Xue-Xi Li 52true METHODS: Retrieved Chinese and English databases such as Weipu, WanFang, PubMed, EMBASE etc, and carried out relevant clinical research on the use of OCT to examine macular area and RNFL of adolescents and children with monocular anisometropic amblyopia from 1995-01-01/2019-12-08 screening, evaluation and data extraction, including the thickness of central fovea, central area of macular fovea with diameter 1mm, the inner ring area with 1-3mm, the thickness of the outer ring area with 3-6mm, and the RNFL of monocular anisometropia amblyopia patients into studies, then do Meta-analysis with the RevMan 5.3 software.

RESULTS: Results of the time-domain OCT(TD-OCT)study showed that the thickness of macular fovea in the amblyopic eyes and the thickness of the central area of the macular fovea with diameter 1mm were greater than those of the contralateral non-amblyopic eyes(P<0.05), and the average thickness of RNFL in amblyopic eyes was thicker in the contralateral eye(P>0.05). Results of the study using frequency domain OCT(SD-OCT)showed that the thickness of macular fovea and the thickness of each zone in amblyopic eyes were greater than those of the contralateral non-amblyopic eyes, except for the central area of the macular fovea with diameter 1mm and the outer ring area below 3-6mm. In addition, the rest of the comparisons were different(P<0.05); the average thickness of RNFL and the thickness of each zone of the nose in amblyopic eyes were larger than those of the contralateral non-amblyopic eyes(P<0.05).

CONCLUSION: Thickness of the macular area and RNFL of the amblyopic eye of monocular anisometropic amblyopia is higher than that of the contralateral non-amblyopic eye, and amblyopia mainly causes the thickness of the macular fovea to increase within 1mm diameter.]]> 2020/8/19 19:18:39 Yang-Yang Wu, Hong Luo and Jiao Li 51true METHODS: Databases such as CNKI, Wanfang, Weipu, China Biomedical, PubMed, Web of Science, OVID, Cochrane Library, and ClinicalTrial.gov were searched. From the establishment of the database to December 31, 2019 on rituximab clinical studies on the treatment of thyroid associated ophthalmopathy. The clinical activity score of thyroid associated ophthalmopathy before and after treatment was used as the main judgment index of curative effect. The retrieved clinical studies were analyzed using RevMan 5.3 statistical software.

RESULTS: Six studies were included, two were randomized controlled trials, and four were cohort studies. Meta analysis showed that the application of rituximab in the treatment of moderate to severe thyroid associated ophthalmopathy can significantly reduce the clinical activity score of patients, and has statistical significance \〖SMD=-5.04, 95% CI(-7.08 to -3.01), P<0.00001\〗.

CONCLUSION: Rituximab can significantly reduce the clinical activity score of patients with moderate to severe thyroid associated ophthalmopathy, and has a good effect on disease control.]]> 2020/7/22 11:15:58 Jin-Hai Yu, De-Quan Dai, Ping Zhang, Hong-Fei Liao, Yao Qin and Yao-Hua Wang 50true METHODS:Retrieved from PubMed, Embase, Cochrane Library, Web of Science, CBM, CNKI, CQVIP, and CECDB databases, randomized controlled trials(RCT)and retrospective clinical control trials(CCT)about the difference between the efficacy of 577nm subthreshold micropulse diode laser and conventional laser in the treatment of diabetic macular edema were collected. The search time was from the establishment of the library until August 2019. Meta-analysis was performed by using RevMan 5.3/Stata 14.0 software after screening the literature, extracting the data, and evaluating the quality of the literature by two researchers.

RESULTS: A total of 7 studies, 6 RCTs and 1 CCT involving 401 patients and 545 eyes were included. The results of Meta-analysis showed that the best corrected visual acuity(BCVA)measured values in the 577nm subthreshold micropulse diode laser group were higher than the conventional laser group \〖95% CI(0.02, 0.08), P=0.002\〗. The macular retinal thicken measured values in the 577nm subthreshold micropulse diode laser group was significantly lower the conventional laser group \〖95% CI(-26.96 to -10.88), P<0.00001\〗. The mean sensitivity within macular 10° examination measured values in the 577nm subthreshold micropulse diode laser group was significantly higher than that conventional laser group \〖95% CI(1.56 to 2.39), P<0.00001\〗.

CONCLUSION: 577nm subthreshold micropulse diode laser can not only better improve the visual function of patients with DME, but also have a higher safety in treatment. 577nm subthreshold micropulse diode laser has good research value for the treatment of DME, it's worthy of application and promotion in clinical practice.]]> 2020/5/25 15:43:00 Fan Hang, Wei Tan and Zhi-Hua Huang 49true METHODS: RCTs on the use of trypan blue for capsular staining in phacoemulsification were retrieved from China Knowledge Network(CNKI), Wanfang Database, Weipu Database, SinoMed, PubMed, SpringerLink, Clinicalkey, Medline, Cochrane Library, Web of Science, OVID, Embase. The search time was from the establishment of the databases to April 2019.The Meta-analysis of the included literature was made by Revman 5.3 and R 3.7.

RESULTS: Eight trials included 378 eyes were selected. Meta-analysis showed that the number of corneal endothelial cell loss between 0.02%, 0.06% or 0.1% trypan blue capsule staining group(193 eyes)and non-stained or placebo staining group(185 eyes)changed without statistical significance \〖Within 1mo after operation(WMD=-10.47, 95% CI=-26.44-5.61, P=0.20); 1mo after operation(WMD=-60.72, 95% CI=-170.92-49.49, P=0.28)\〗. The percentage of corneal endothelial hexagonal cell loss at 1mo after operation changed without statistical significance(WMD=0.50, 95% CI=-2.09-3.09, P=0.71). The central corneal thickness(CCT)at 1mo after operation changed without statistical significance(WMD=3.10, 95% CI=-5.77-11.98, P=0.49). The coefficient of variation(CV)changed without statistical significance(WMD=-1.00, 95% CI=-2.86-0.86, P=0.29).

CONCLUSION: 0.02%, 0.06% or 0.1% trypan blue capsule staining in phacoemulsification have no significant effect on the number and function of corneal endothelial cells.]]> 2020/5/25 15:43:01 Yang Su, Min Fu and Guo-Guo Yi 48true METHODS: The Cochrane Library, Embase, Web of Science, and CNKI, Wanfang data, and VIP database were comprehensively searched for studies comparing conbercept versus ranibizumab in patients with RVO-ME. Best-corrected visual acuity(BCVA), central macular thickness(CMT), intraocular pressure(IOP), mean number of intravitreal injections and adverse events were extracted from the final eligible studies. RevMan 5.3 software was used for relevant index data analysis. Random and fixed effect models were employed to evaluate heterogeneity and the publication bias.

RESULTS: A total of 14 randomized controlled trial(RCT)studies, involving 1 350 eyes. There was no significant difference in BCVA improved between the two groups after treatment 2wk, 2mo, 3mo and 6mo, but there was significant difference in BCVA improved after treatment 1wk [WMD=-0.03; 95% CI(-0.05, -0.02); P<0.0001] and 1mo [WMD=-0.03; 95% CI(-0.04, -0.01); P=0.001]. The conbercept treatment group had higher CMT reduction compared with ranibizumab treatment group after 6mo treatment, and there was a significant difference [WMD=-28.77; 95% CI(-54.23, -3.31); P=0.03], and there were no significant difference between two groups in others period of time. There were no significant difference in intraocular pressure(IOP)and adverse events between the two groups [OR=0.95; 95% CI(0.57, 1.57); P=0.84]. However, the use of conbercept had a fewer mean number of injections.

CONCLUSION: CMT and BCVA were improved significantly both in the conbercept and ranibizumab groups. Compared with ranibizumab, conbercept group did not have greater improved BCVA, but with a more CMT reduction after 6mo. The advantage of conbercept is fewer injections and maybe it is better for treatment of RVO-ME.]]> 2020/3/13 19:43:57 Li Peng, Xiao-Hua Zhang, Na Lao and Qing Xie 47true METHODS: PubMed, EMbase, Web of Science. The Cochrane Library, CBM, CNKI, VIP and WanFang Data databases were electronically searched to identify randomized controlled trials(RCTs)of Qiju Dihuang Pill on xerophthalmia from the inception of the databases to June 2019. Two reviewers independently screened literatures, extracted data and assessed risk of bias of the included trials. The Meta-analysis was conducted with RevMan 5.3 and Stata 12.0 software.

RESULTS: Totally 17 RCTs with 1 662 patients were included. The results of the Meta-analysis showed that, compared with the control group, the Qiju Dihuang Pill group had statistical difference in BUT(MD=4.32, 95% CI 3.15 to 5.49, P<0.00001), SⅠt(SMD =1.07, 95% CI 0.71 to 1.42, P<0.00001), FL(MD= -1.01, 95% CI -1.61 to -0.40, P=0.001), efficiency(OR=7.22, 95% CI 4.36 to 11.93, P<0.00001). There were no serious adverse reactions in either group. The results of GRADE showed that the level of evidence of BUT, SⅠt, efficiency was low, and the level of evidence of FL was very low.

CONCLUSION: The current evidence indicated that Qiju Dihuang Pill had a better therapeutic effect on xerophthalmia than conventional treatment, and no serious adverse reactions were reported in the study. Considering the limitations of the quality and quantity of the included studies,more well-designed randomized controlled trials are required to verify the above conclusions.]]> 2019/12/20 14:53:56 Xi-Li Xiao and Juan Li 46true METHODS:The PubMed, The Cochrane Library, CNKI, Sinomed, Metstr, Wanfang Database were searched for Meta-analysis of the literature on the objective visual quality after multifocal intraocular lens implantation. The retrieval time limit is from the establishment of the database to December 31, 2019. The objective visual quality was evaluated based on the objective visual quality analysis system Ⅱ(OQAS Ⅱ), which included object scatter index(OSI), modulation transfer function cut off(MTF cut off), Strehl ratio(SR), predicted 100% contrast visual acuity(OV100%), predicted 20% contrast visual acuity(OV20%), and predicted 9% contrast visual acuity(OV9%).

RESULTS: A total of 8 articles met the inclusion criteria of this study, a total of 432 cases(567 eyes). Meta-analysis showed that there was significant difference between multifocal intraocular lens and monofocal control group in OSI \〖MD=0.66, 95% CI(0.42-0.90), P<0.05\〗, but there was no significant difference in MTF cut off \〖MD=-1.94, 95% CI (-5.58-1.70), P=0.30\〗, SR\〖MD=0.00, 95%CI (-0.02-0.02), P=0.87\〗, OV100% \〖MD=-0.02, 95%CI(-0.14-0.11), P=0.76\〗, OV20% \〖MD=-0.03, 95% CI(-0.14-0.08), P=0.60\〗, OV9% \〖MD= -0.01, 95% CI (-0.09-0.07), P=0.82\〗.

CONCLUSION: The increase of objective scattering after multifocal intraocular lens implantation may lead to the decrease of visual quality, and the other parameters have no significant difference with the control group. However, no patient follow-up was reported in the included studies. Due to the changes and adaptability after operation, the long-term evaluation of objective visual quality of patients after multifocal intraocular lens implantation needs further research.]]> 2020/11/19 16:34:48 Meng Liu, Cheng Dai and Bin-Zhong Li 45true METHODS:The comparative studies on macular edema secondary to RVO were collected in Wanfang database, CNKI, Pubmed, The Cochrane Library, Google scholar and other databases. The best corrected visual acuity, macular fovea retinal thickness, the number of adverse reactions and the number of injections were systematically evaluated. Compare the effects of the two. RevMan 5.3 statistical software was used to analyze the data.

RESULTS:A total of 1 337 patients were included in 16 studies. The results of systematic evaluation showed that in 1+PRN injection regimen and in the treatment of BRVO secondary ME patients, the regression effect of ME was more obvious, and the injection times were less in 3+PRN injection regimen and treatment of CRVO secondary ME patients. In comparison with the effect of ranibizumab, there was no significant difference in the improvement of visual acuity and the occurrence of side effects when 3+PRN injection was used to treat ME secondary to CRVO. When 1+PRN injection was used to treat Brvo secondary ME, the total number of injections was not statistically significant.

CONCLUSION:Compared with ranibizumab, conbercept showed better effect in different injection regimens and different types of vein occlusion that is less injection times or better ME regression effect.]]> 2020/11/19 16:34:48 Man Yu, Qiu-Yue Liu, Qin Zou, Yan-Jun Chen and Xiao-Li Yang 44true METHODS: Computers were used to search PubMed, EMbase, Cochrane Library, American Scientific Citation Index Database(SCI), China Knowledge Network(CNKI), Chinese Science and Technology Journal Database(VIP), Wanfang Database, China Biomedical Document Service System(CBM), and to find literature about ranibizumab and Ahmed drainage valve implantation in the treatment of NVG. At the same time, relevant references were consulted. The search time limit was establishment until March 20, 2020. Quality evaluation and data extraction on the included studies were performed. RevMan 5.3 and STATA 12.0 software were used for Meta-analysis.

RESULTS: The included 7 clinical studies included 346 patients(349 eyes), and the quality was evaluated as medium to high quality. The homogeneity of the basic characteristics of various studies was better. Compared with the pure Ahmed drainage valve implantation group(the control group), the ranibizumab combined with Ahmed drainage valve implantation group(the experimental group)had lower intraocular pressure at 1wk and 1mo after surgery. There was no statistical difference at 6mo after surgery. The BCVA of the experimental group was better than that of the control group at 1mo and 3mo, and there was no significant difference at 6mo after surgery. There was no significant difference in the rate of anterior chamber bleeding and the number of anti-glaucoma drugs used between the two groups.

CONCLUSION: Compared with pure Ahmed drainage valve implantation, ranibizumab combined with Ahmed drainage valve implantation has better postoperative intraocular pressure and best corrected visual acuity in the early stage in the treatment of NVG, and the difference in the late postoperative period is not significant. It cannot reduce the rate of postoperative anterior chamber bleeding, and cannot reduce the use of anti-glaucoma drugs. This conclusion needs to be further confirmed by more high-quality clinical randomized controlled studies.]]> 2020/10/22 16:19:27 Shuai-Zheng Chen and Ya-Lin Mu 43true METHODS: A literature search was implemented in CNKI, Wanfang database, VIP database, PubMed, Medline and Cochrane Library from 2000-01-01 to 2019-12-31. Two researchers independently performed literature search, screening, quality evaluation, and data extraction. Meta-analysis was performed by RevMan 5.3 software. The mean difference and 95% confidence interval were used to measure the measurement data, including best corrected visual acuity, postoperative intraocular pressure, and laser energy. The odds ratio was used to measure the count data, including the rate of lens damage and the incidence of vitreous floaters.

RESULTS: A total of 7 studies were included, including Nd:YAG laser circular posterior capsulotomy and cruciate posterior capsulotomy in 432 eyes. The Meta-analysis showed that there was no significant difference in postoperative best corrected visual acuity between the circular posterior capsulotomy group and the cruciate posterior capsulotomy group, MD=-0.01(95% CI: -0.03-0.01, P=0.32); there was no significant difference in postoperative IOP between the circular posterior capsulotomy group and the cruciate posterior capsulotomy group, MD=-0.60(95% CI: -1.31-0.11, P=0.10); there was no significant difference in laser energy between the two groups, MD=18.82(95% CI: -11.88-49.51, P=0.23); there was also no significant difference in the rate of lens damage and the incidence of vitreous floaters, OR=0.97(95% CI: 0.50-1.87, P=0.93); OR=2.88(95% CI: 0.28-29.26, P=0.37).

CONCLUSION:In the treatment of posterior capsular opacification after cataract surgery with Nd:YAG laser posterior capsulotomy, there is no significant difference in efficacy and safety between circular posterior capsulotomy and cruciate posterior capsulotomy.]]> 2020/9/17 16:45:32 Hai-Long He, Di Chang, Chun-Yuan Zhou, Jin-Da Wang, Kai Cao and Xiu-Hua Wan 42true METHODS: Randomized controlled trials about lifitegrast in the treatment of dry eye disease were searched in CNKI, VIP, CBM, PubMed, Embase and The Cochrane Library databases from inception to March 2019. The collected literatures were strictly screened according to the established inclusion and exclusion criteria, and the Cochrane collaborative network bias risk assessment tool was used to evaluate the quality of the included studies, RevMan 5.3 software was used for meta-analysis of efficacy and safety indicators.

RESULTS: A total of 5 randomized controlled trials that met the inclusion criteria were included in this study, with a total sample size of 2 465 participants. According to the result of Meta-analysis: compared with placebo, after 84d of treatment, the score of corneal staining(CSS)\〖MD= -0.17, 95% CI (-0.29, -0.05), P=0.006\〗, the score of eye dryness(EDS)\〖MD= -7.95, 95% CI (-11.96, -3.93), P=0.0001\〗, all the differences were statistically significant. It showed that lifitegrast eye drops had better effect than placebo in the treatment of dry eye disease. In terms of safety, the incidence of severe adverse reactions \〖OR=0.95, 95% CI (0.50, 1.81), P=0.88\〗; in terms of common adverse reactions, the incidence of adverse reactions such as instillation site irritation, instillation site reaction and dysgeusia were higher than that of placebo(P<0.05).

CONCLUSION: Lifitegrast is effective and safe in the treatment of dry eye disease.]]> 2020/9/17 16:45:32 Ling Li, Ming Yang, Xue-Feng Li and Fu Liu 41true METHODS: Electronic databases of PubMed, EMbase, Cochrane and OVID were searched for studies comparing FLACS-MFIOL and CP-MFIOL. Two independent reviewers performed the data extraction and analyzed. Visual acuity, spherical equivalent(SE), pseudophakic accommodation, cumulative dissipated energy(CDE)and endothelial cell density(ECD)were measured by Review Manager 5.4. Sensitivity and reporting bias were determined through the STATA 14 software.

RESULTS: From 106 screened articles, 1 045 eyes from 6 randomized controlled trials(RCTs)and 5 retrospective cohort studies were included(one of which contained two groups of comparative data). There was no evidence for any important differences in uncorrected distance visual acuity(UDVA)between FLACS-MFIOL and CP-MFIOL group after 1d, 1wk, 1, 3mo and 1a \〖s: -0.02, 95% Confidence Interval(CI)(-0.05, 0.01), P=0.13; s: -0.01, 95% CI(-0.03, 0.01), P=0.24; s: -0.03, 95% CI(-0.06, 0.00), P=0.05; s: -0.03, 95% CI(-0.14, 0.08), P=0.59; s: -0.03, 95% CI(-0.06, 0.00), P=0.10\〗. We found little evidence of any important difference in uncorrected near visual acuity(UNVA)between the two groups after 1d, 1wk, 3mo and 1a \〖s: 0.04, 95% CI(-0.04, 0.12), P=0.30; s: 0.04, 95% CI(-0.06, 0.13), P=0.47; s: 0.00, 95% CI(-0.04, 0.04), P=0.97; s: 0.03, 95% CI(-0.06, 0.12), P=0.54\〗. There was a small advantage in favor of FLACS-MFIOL over CP-MFIOL for UNVA after 1mo \〖s: 0.03, 95% CI(0.00, 0.06), P=0.04; s: 0.06, 95% CI(-0.02, 0.15), P=0.14\〗. In eyes treated with FLACS-MFIOL, SE showed no difference compared to CP-MFIOL \〖s: 0.06, 95% CI(-0.02, 0.15), P=0.14\〗, however, better than CP-MFIOL in distance and near pseudophakic accommodation \〖s: 0.57, 95% CI(0.42, 0.72), P<0.001; s: 1.32, 95% CI(0.99, 1.64), P<0.001\〗. Smaller CDE \〖s: -1.94, 95% CI(-2.59, -1.30), P<0.01; s: -3.81, 95% CI(-5.66, -1.96), P<0.01\〗 of Ⅱ and Ⅲ nucleus patients and increased ECD \〖s: 111.75, 95% CI(86.27, 137.23), P<0.01\〗 in FLACS-MFIOL group were analyzed. The sensitivity analysis indicated that the results were robust and no obvious reporting bias.

CONCLUSION: Compared to CP-MFIOL, FLACS-MFIOL makes a better visual quality and pseudophakic accommodation, as well as reducing endothelial cell loss and phacoemulsification energy.]]> 2021/8/18 21:33:00 Hui-Min Ge, Wei-Ling Yan, Xiang-Zhong Xu and Qin Jiang 40true METHODS: Using “vitamin C” and “corneal ulcer” as keywords, the randomized controlled trials(RCT)of subconjunctival injection of vitamin C in Embase, Cochrane library, Pubmed, CNKI and Wanfang database in the treatment of corneal ulcer was searched. Relevant reference published before February 2021. The risk bias tool provided by the Cochrane cooperation scale was used to assess the risk bias of included studies of RCTs. The publication bias of the included studies were assessed by the Egger's test with Stata software. Meta-analysis was performed with RevMan 5.3.

RESULTS: A total of 32 eligible articles were included, all of which were Chinese literatures, with a total of 4 514 patients. The control group was treated with routine treatment, and the experimental group was treated with subconjunctival injection of vitamin C combined with routine treatment. The Meta-analysis showed that the experimental group was better than control group(OR=4.61, 95%CI:3.70, 5.74). The recurrence rate was lower than control group(OR=0.24, 95%CI: 0.18, 0.31). The cure time in experimental group was shorter than control group(MD= -6.29, 95%CI: -7.08, -5.51), 32 studies do not adequately report adverse drug reactions(ADR). Egger's test was performed on the total effective rate, recurrence rate and cure time. The results showed that there was publication bias in the total effective rate and cure time. Trim and fill method showed that the publication bias did not affect the results.

CONCLUSION: Subconjunctival injection of vitamin C is feasible in the treatment of corneal ulcer. The clinical effect, cure time and recurrence rate were better than routine treatment. However, due to the low intensity of the included research evidence, more multicenter, randomized double-blind clinical trials are needed to improve the evidence intensity of vitamin C in the treatment of corneal ulcer.]]> 2021/7/21 22:23:12 Xiao-Zhuang Li, Wen-Jing Yin, Qi-Pei Fan, Feng Liu and Jun-Ji Wu 39true METHODS: A systematic review of the literature was performed to examine the diagnostic used OCTA in DR to date. Six electronic databases were searched to find relevant studies. We conducted a literature search in English and Chinese databases. Two authors extracted basic data, the VD of superior capillary plexus(VD_SCP), the VD of deep capillary plexus(VD_DCP), the area and the perimeter of FAZ. We used a variety of Meta-analytic methods, including WMD forest maps, funnel plot, Begg test and sensitivity analysis, to confirm the final results.

RESULTS: Totally 24 studies recruiting 2 305 eyes were included. Patients with DR showed statistical difference in VD_SCP \〖WMD= -5.78, 95%CI (-7.67 to -3.88), P<0.05\〗, VD_DCP \〖WMD= -5.08, 95%CI(-6.49 to -3.67), P<0.05\〗, the perimeter of FAZ \〖WMD=0.57, 95%CI(0.36 to 0.78), P<0.05\〗, the area of FAZ \〖WMD=0.08, 95%CI (0.06 to 0.10), P<0.05\〗 with healthy controls.

CONCLUSION: In general, there was a trend towards a larger area and longer perimeter of FAZ in patients with DR. It can also be concluded that the VD of FAZ is higher in healthy controls. While questions remain regarding OCTA practical applicability in its present form, with continuing development and improvement of the technology, the diagnostic value of OCTA in DR is likely to become evident.]]> 2021/7/21 22:23:12 Ze-Peng Xu, Ni Tian, Xin-Guang Long, Xiao-Yi Yu, Mei-Xia An, Qiu-Hong Liu, Xiao-Chuan Wang, Rui-Ying Zhong, Hong Liu and Li-Hua Lian 38true METHODS: PubMed, Embase, Web of science, Cochrane library, CNKI, Wanfang, CBM and VIP databases were searched from inception to October 27, 2020 in diagnosing CNV of wARMD by OCTA. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies by QUADAS-2 standard. Meta-analysis was performed by Meta-Disc 1.4 and Stata 16.0 softwares.

RESULTS: A total of 11 studies involving 995 eyes were included. The results of Meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic ratio, the AUC of sROC and the positive post-test probability were 0.88 \〖95%CI (0.83, 0.92)\〗, 0.95 \〖95%CI (0.85, 0.99)\〗, 18.45 \〖95%CI (5.36, 63.52)\〗, 0.12 \〖95%CI (0.08, 0.18)\〗, 152.73 \〖95%CI (36.39, 641.05)\〗, 0.95 \〖95%CI (0.92, 0.96)\〗 and 0.96 respectively.

CONCLUSION: OCTA has significant diagnostic value for CNV of wARMD, especially for patients with early wARMD.]]> 2021/6/24 15:28:01 Shuang Liu, Shi-Yi Wang, Zi-Chen Wang and Ying Yu 37true METHODS: Randomized controlled clinical studies on combined application of corneal bandage contact lens after pterygium excision were retrieved from PubMed, Cochrane Library, Wanfang, VIP, CNKI and other databases from May 2014 to May 2020. Data were extracted and Meta-analysis was performed.

RESULTS:Totally 11 randomized controlled clinical studies were included, including 10 in Chinese and 1 in English, with 864 patients. Meta-analysis results showed that 1d postoperative \〖MD= -1.57, 95%CI=(-1.72, -1.41), P<0.00001\〗, 2d postoperative \〖MD= -1.35, 95%CI=(-1.59, -1.11), P<0.00001\〗, 7d postoperative \〖MD= -0.64, 95%CI=(-0.78, -0.50), P<0.00001\〗 combined application of corneal bandage contact lens can better reduce the degree of ocular pain in patients; And 1d postoperative \〖MD= -1.23, 95%CI=(-1.51, -0.95), P<0.00001\〗, 7d postoperative\〖MD= -0.44, 95%CI=(-0.50, -0.39), P<0.00001\〗 combined application of corneal bandage contact lens can better promote the condition of corneal epithelium.

CONCLUSION:The bandage contact lens could markedly release pain response after pterygium excision surgery, promote corneal epithelium recovery, which is beneficial to reduce the symptoms of clinical discomfort.]]> 2021/6/24 15:28:01 Yue-Cong Ren, Hong Yan and Jian Zhang 36true METHODS:PubMed, EMbase, Web of Science, The Cochrane Library, CBM, CNKI, Wan Fang Data VIP databases were electronically searched to collect case-control studies, cohort studies and cross-sectional studies on the risk factors of ARMD in China from inception to December, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then, Meta-analysis was performed by using RevMan 5.3 software.

RESULTS: A total of 27 studies involving 204 767 objects and 10 risk factors were included. The results of Meta-analysis showed that smoking \〖OR=2.30, 95%CI (1.95, 2.71), P<0.0001\〗, hypertension \〖OR=1.55, 95%CI (1.23, 1.95), P=0.0002\〗, HTRA1 rs11200638\〖OR=4.35, 95%CI (2.35, 7.48), P<0.0001\〗, CFH Y402H \〖OR=3.28, 95%CI (2.51, 4.28), P<0.00001\〗, LOC387715 rs10490924 \〖OR=7.09, 95%CI (3.48, 14.44), P<0.00001\〗. Desciptive analysis results showed that DR, Cataract surgery, NO₂, CO and HBV infection were risk factors of ARMD in China.

CONCLUSION: Current evidence shows that smoking, hypertension, HTRA1 rs11200638, CFH Y402H, LOC387715 rs10490924, DR, cataract surgery, NO₂, CO and HBV infection are the risk factors of ARMD in China.]]> 2021/5/20 16:38:37 Hao Zhang, Jing Gao, Ding-Xi Bo, Rui-Rui Liu, Yi-Zhu Zhong and Yun Liang 35true METHODS: Randomized controlled trials(RCTs)comparing the efficacy of vitrectomy combined with or without anti-VEGF therapy for PDR were retrieved from databases including PUBMED, EMBASE, Cochrane Central Register of Controlled Trials(CENTRAL)and Web of Science. The retrieval time was from the establishment of the databases to July 2020. According to the inclusion and exclusion criteria, the literature was selected, then data extraction and quality evaluation was completed. Primary evaluation measures included postoperative incidence of retinal detachment, central retinal thickness(CRT), and best corrected visual acuity(BCVA).

RESULTS: In this article, 11 randomized controlled studies(880 eyes)were included. Meta-analysis results showed that the incidence of retinal detachment after vitrectomy was significantly lower in PDR patients who received anti-VEGF injection before vitrectomy than in patients who did not receive anti-VEGF injection \〖Risk ratio(RR)=0.39, 95% Confidence interval(CI)0.22 to 0.71, P=0.002\〗. There were significant differences in the incidence of retinal detachment after vitrectomy between the anti-VEGF group and the non-VEFG group in both Asian and non-Asian populations(Asian: RR=0.20, 95%CI 0.05 to 0.87, P=0.03; Non-Asian: RR=0.46, 95%CI 0.24 to 0.89, P=0.02). The central retinal thickness of PDR patients who received preoperative anti-VEGF therapy was significantly lower than that of patients who did not receive anti-VEGF therapy 3 and 6mo after PPV(MD=-78.49, 95%CI -94.81 to -62.17, P<0.00001. MD= -39.62, 95%CI -48.44 to -30.80, P<0.00001). The BCVA at 6mo after PPV in PDR patients with preoperative anti-VEGF treatment was better than that in patients without preoperative anti-VEGF treatment(MD=-0.16, 95%CI -0.21 to -0.10, P<0.00001).

CONCLUSION: Anti-VEGF injection before PPV can effectively reduce the incidence of retinal detachment, alleviate postoperative macular edema, reduce the central retinal thickness, and improve BCVA in PDR patients.]]> 2021/5/20 16:38:38 Wen-Qiang Hu, Xiao-Ping Ji, Xue-Bin Zhou, Hui Zou, Yang Gao and Zao-Xia Liu 34true 2021/4/21 21:12:02 Yu Huang, Jie Li, Xiao-Qing Liu, Dong-Dong Li, Li-Hao Chen, Jun Peng and Qing-Hua Peng 33true 2021/4/21 21:12:03 Hao-Bo Fan, Xiu-Ping Tang, Yun-Chun Zou, Li-Yuan Yang, Jia Tao, Ying Wang and Wei-Qi Song 32true 2021/4/21 21:12:03 Tong Li, Ruo-Xin Wang, Jin Wang, Hong-Na Wang and Xue-Hui Zhang 31true 2021/3/25 20:05:44 Wan-Yu Sun, Xing Liao, Si-Yu Long, Zi-De Zhao, Bin-Bin Wei, Man Li and Ying Wang 30true METHODS: From January 2015 to January 2020, used computer to search the clinical contrast test of FS-LASIK and ICL implantation published in CNKI database, Wanfang database, Chongqing VIP Chinese Sci tech journal full-text database, China Bioligy Medicine disc(CBMdisc), Cochrane Library, PubMed, MEDLINE and other databases,using rev-man5.3 statistical software for Meta-analysis and statistical processing.

RESULTS: Totally 11 studies were brought into the analysis, including 673 patients and 1 301 operative eyes. The results of Meta-analysis showed that there was no statistical significance in the safety, objective visual quality, spherical equivalent degree, cylinder, diopter of correction, trefoil aberration and coma aberration of FS-LASIK and ICL implantation after operation, but there was statistical significance in the effectiveness, total higher-order aberration, spherical aberration and contrast sensitivity of FS-LASIK and ICL implantation after operation.

CONCLUSION: Compared with ICL implantation, the total high-order aberrations and spherical aberrations of FS-LASIK are larger, and the contrast sensitivity is lower. The ICL implantation has more clinical-effect superioity than FS-LASIK, meanwhile it has reversibility and less complications.]]> 2021/2/24 14:14:54 Jian Shi, Li-Hao Chen, Qian-Hong Liu, Xiao-Lei Yao and Qing-Hua Peng 29true METHODS: The PubMed, Embase, Web of Science, the Cochrane Library, CNKI, CQVIP, CBM, OVID and Wanfang were systematically searched. All comparative studies of IVB or IVR as treatment for ROP were included. Two independent reviewers performed the date extraction and assessed study quality. Meta-analysis was performed using Review Manager 5.3 software. The retreatment rate was defined as the primary outcome. Secondary outcomes were prevalence of complete vascularization and myopic(spherical equivalent, SE).

RESULTS: Eight non-randomized studies, including a total of 885 eyes were included in this study. Compared with IVB-treated children, IVR-treated children have higher retreatment rate \〖OR=0.55, 95% CI:0.34-0.88, P<0.05\〗, less spherical equivalent \〖WMD= -1.44, 95% CI: -2.28 to -0.00, P<0.05\〗, and the same percentage of complete vascularization \〖OR=2.15, 95% CI: 0.80-0.576, P>0.05\〗.

CONCLUSION: Both IVR and IVB can complete the vasculization of the retina in the treatment of type 1 ROP, but the two treatments have their own advantages. IVR has little effect on the refractive effect in children, but its effect in reducing the retreatment rate is worse than IVB.]]> 2021/2/24 14:14:54 Rong-Xia Cao, Yan-Jie Li, Wei-Shai Liu, Zi-Chao Bai, Liu-Sen Yang and Xian Li 28true METHODS:The computer searched PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database(CBM), Wan-Fang Database, China National Knowledge Infrastructure(CNKI)database and Weipu database. Search time was limited from their inception to May 2020. A comprehensive search strategy was designed to identify all randomized controlled trials(RCTs)comparing TCM-WM therapy versus WM therapy alone. The methodological quality of the included trials was assessed by the quality grade evaluation used in Cochrane handbook. Data extraction and Meta-analysis were performed by RevMan5.3 statistical software.

RESULTS: Twelve RCTs were included. The Meta-analysis showed that compared with the WM therapy alone in treating TON, TCM-WM therapy was better in improving the effective rate \〖RR=1.33, 95% CI(1.23-1.45), P<0.001\〗, visual acuity \〖MD=0.18,95% CI(0.14-0.23), P<0.001\〗, visual field mean defect \〖MD=-3.08, 95% CI(-5.20-0.96), P=0.004\〗, P₁₀₀ lantency \〖MD=-9.47, 95% CI(-16.37-2.57), P=0.007\〗 as well as P₁₀₀ amplitude \〖MD=1.44, 95% CI (0.22-2.66), P=0.02\〗. Two researches reported the occurrence and treatment of adverse reactions, and the remaining included researches did not report the adverse reactions.

CONCLUSION:The TCM-WM therapy in treating TON is more effective compared with the WM therapy alone.]]> 2021/1/19 16:56:26 Qiong Wu, Jian Zhou, Qi-Ping Wei, Xiao-Ling Yan, Tian-Tian Li, Hang Shi, Yu-Mei Zheng and Xiao-Yu Zhou 27true METHODS: Randomized controlled trials(RCTs)comparing the efficacy of anti-VEGF and laser therapy for type 1 ROP were retrieved from PubMed, EMbase, CBM, The Cochrane Library, WanFang Data, CNKI and VIP databases. The search time was from the establishment of the databases to January 2020. The data were extracted according to the inclusion and exclusion criteria. After quality evaluation, then Meta-analysis was made by Revman 5.3 software.

RESULTS: A total of 6 RCTs were included. The results of Meta-analysis showed that: there was no statistical difference in the recurrence incidence between anti-VEGF group and laser group [RR=0.94, 95% CI (0.17-5.23), P=0.94]; subgroup analysis revealed a statistical significant in zone Ⅰ[RR=0.17, 95% CI (0.05-0.62), P=0.007], while zone II has no statistical significant [RR=2.20, 95% CI (0.07-73.48), P=0.66]. Compared with the laser group, the retreatment rate [RR=2.36, 95% CI (0.70-7.99), P=0.17]was statistical significant; There was no significant difference in subgroup analysis of zone Ⅰ[RR=0.33, 95% CI (0.01-7.50), P=0.49], while the difference in zone Ⅱ[RR=13, 95% CI (1.84-92.01), P=0.01] was statistically significant. There was no significant difference in the incidence of adverse reactions between the two groups[RR=0.87,95% CI(0.54-1.40),P=0.57].

CONCLUSION: Laser and anti-VEGF treatment are equally effective. Anti-VEGF has less recurrence rate in zone Ⅰ while laser is more effective in the retreatment rate in zone Ⅱ.]]> 2021/1/19 16:56:26 Qi Xiong, Chao Zhang, Xiao-Jun Cai, Ai-Hua Yu and Min Ke 26true METHODS: The literatures related to randomized controlled clinical studies on the treatment of BRVO-ME with laser and Ranibizumab in Embase, The Cochrane Library, PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Database and China Science and Technology Journal Database(VIP)were systematically retrieved, and the risk assessment was carried out and data indicators were extracted for the included studies. RevMan 5.3 software was used for data analysis and funnel plot was used to evaluate publication bias.

RESULTS: Totally 7 studies were included, with 641 eyes. There was no significant difference in the best corrected visual acuity(BCVA)between the laser combined with Ranibizumab group and the simple Ranibizumab group at 12mo \ and 24mo \ after treatment. There was no significant difference in central foveal thickness between the two groups at 12mo \ and 24mo \. There were no statistically significant differences in the injection times of Ranibizumab and the incidence of final adverse events between the two groups at 12mo and 24mo after treatment.

CONCLUSION: Compared with the treatment of BRVO-ME with simple Ranibizumab, there was no significant difference in the long-term efficacy of vision and central foveal thickness for the laser combined with Ranibizumab, and there was no significant difference in the injection times and safety of Ranibizumab.]]> 2020/12/22 18:57:47 Xiang-Rui Wu, Feng-Ming Liang and Shuai Song 25true METHODS: Chinese and English electronic databases(Pubmed, Embase, Cochrane, CNKI, Wanfang and Weipu)were searched to obtain qualified random controlled test(RCT)researches from their foundation to January 2020. According to inclusion and exclusion criteria, two researchers retrieved the literature independently, extracted data and evaluate methodological quality. Review Manager 5.3 was used for Meta-analysis.

RESULTS: A total of 5 RCTs were identified with 212 patients. There was no significant difference in patients' best correct visual acuity(BCVA)improvement in 1mo, 3mo and 6mo between anti-VEGF combined with steroids and anti-VEGF monopoly. Significant difference was found in the relieve of ME in 1mo and 3mo(1mo: MD=-20.89, 95% CI: -34.65 to -7.13, P=0.003; 3mo: MD=-22.83, 95% CI: -33.68 to -11.97, P<0.0001), but not in 6mo between two groups. As for side effects and complications, the combination group occurs more often than the monopoly group(P=0.02). Meanwhile, significant difference was found in the number of injections between two groups(P<0.001).

CONCLUSION: Compared with the single use of anti-VEGF drugs, anti-VEGF drugs combined with corticosteroids for the treatment of ME secondary to RVO have the characteristics of rapid onset, fewer injections, and more economical. The treatment process should closely follow the patient's intraocular pressure and lens status.]]> 2020/12/22 18:57:47 Zhuang Hao, Jue Wang, Shuai-Fei Ji and Jie Zhang 24true METHODS: Literatures were searched from domestic and foreign databases such as PubMed, Embase, Cochrane Library, Wanfang, and CNKI, and the paper editions of relevant journals were consulted as well. The retrieval period of literature was from January 2000 to January 2021. The screened literatures were evaluated and extracted by two experienced researchers. After performing the evaluation guidelines of Cochrane collaboration and the Newcastle-Ottawa Scale(NOS), the Rev Man 5.4 software was applicated to complete the Meta-analysis.

RESULTS:Seven references(328 eyes)were involved in this analysis. The results of the Meta-analysis showed that the two groups had statistically significant differences in best corrected visual acuity(BCVA)>0.5 eyes(RR=2.00, 95%CI: 1.18-3.37, P=0.01), IOL shift(RR=0.28, 95%CI: 0.17-0.46, P<0.00001)and mild or above opacification of the visual axis(RR=0.35, 95%CI: 0.19-0.65, P=0.0007)after surgery. However, there was no significant difference in the occurrence of posterior synechia(RR=0.67, 95%CI: 0.10-4.33, P=0.67)and very mild opacification of the visual axis(RR=1.05, 95%CI: 0.64-1.73, P=0.84).

CONCLUSION:IOL incarceration in the treatment of pediatric cataract can significantly improve postoperative BCVA, reduce occurrence of IOL shift and prevent mild or above opacification of the visual axis, which has more advantages in overall clinical efficacy. But more high quality prospective studies should be still required for further analysis.]]> 2021/9/16 22:17:09 Ling-Fang Zheng, Shu-Hua Ni, Juan-Mei Zhang, Yi-Xuan Fu, Wan-Jing Xu, Shuang Zhao and Jun Zhao 23true in situ keratomileusis(FS-LASIK).

METHODS: We searched on PubMed, the Cochrane Library, Medline, CNKI, CBM, VIP and WanFang Data database for randomized controlled trials(RCTs)and comparative studies(CTs). The published languages were limited to Chinese and English. The risk bias tool provided by the Cochrane cooperation scale and Newcastle-Ottawa Scale were used to assess the risk bias of included studies of RCTs and CTs. The published biases of included studies were assessed by the Egger test. Meta-analysis was performed with Review Manager 5.4.

RESULTS: Two randomized controlled trials and six comparative studies with a total of 987 subjects were included(482 in the topography-guided FS-LASIK group, 505 in the wavefront optimized FS-LASIK group). The Meta-analysis showed that the topography-guided group has a better effect than the wavefront-optimized group in spherical equivalent, the difference between the two groups was statistically significant \〖WMD=0.11, 95%CI (0.07, 0.14), P<0.00001\〗. And the results also indicated that there was a significant difference between the two groups with HOAs \〖WMD= -0.09, 95%CI (-0.13,-0.05), P<0.0001\〗, spherical aberrations \〖WMD=-0.05, 95%CI (-0.09, -0.01), P=0.008\〗 and coma \〖WMD=-0.08, 95%CI (-0.12, -0.05), P<0.00001\〗.

CONCLUSION: Based on the available evidence, topography-guided FS-LASIK has higher diopter and lower HOAs, spherical aberrations and coma than wavefront-optimized FS-LASIK.]]> 2021/9/16 22:17:09 Hao-Bo Fan, Wei-Qi Song, Xiu-Ping Tang, Ying Wang, Si-Yu Chen, Juan Xie and Yun-Chun Zou 22true METHODS: Databases such as PubMed, Cochrane Library, Web of Science, Embase, CNKI, CBM, VIP and WanFang Data were searched for randomized controlled trials(RCT)from the establishment of the database to November 2021 on the effects of femtosecond laser cataract surgery and conventional ultrasound cataract surgery on corneal endothelial cells. Language is limited to Chinese or English. The literatures were evaluated by the Manual of Systematic Evaluation of Cochrane Interventions and the modified Jadad Scale. Stata 15.0 software was used for statistical analysis.

RESULTS: A total of 13 RCT were included, including 1 446 eyes in the FLACS group and 1 472 eyes in the CUCS group. The Meta-analysis results showed that the cumulative dissipated energy(CDE)in FLACS group was obviously lower than that in CUCS group \〖WMD=-3.84, 95%CI (-6.30, -1.38), P=0.002\〗. The effective phacoemulsification time(EPT)in the FLACS group was obviously lower than that in the CUCS group [WMD=-3.03, 95%CI(-4.00, -2.05), P<0.001]. The density of corneal endothelial cells in both the FLACS group after surgery at 1 and 3mo was higher than that in CUCS group \〖WMD=121.76, 95%CI(79.31, 164.20), P<0.001; WMD=76.04, 95%CI(19.25, 132.82), P=0.009\〗; The thickness of the central cornea in the CUCS group was significantly thicker than that in the FLACS group at 1wk after the surgery \〖WMD=-9.89, 95%CI (-18.60, -1.18), P=0.026\〗; The incidence of postoperative corneal edema in the FLACS group was less than that in the CUCS group \〖RR=0.46, 95%CI(0.32, 0.66), P<0.001]. There were no differences in the percentage of hexagonal cells and coefficient of variation of corneal endothelial cells between the two groups.

CONCLUSION: Compared with conventional ultrasound cataract surgery, femtosecond assisted cataract surgery can significantly reduce the phacoemulsification energy and the duration of the phacoemulsification energy, and significantly reduce the loss of corneal endothelial cells in the early postoperative period, while reducing the occurrence of postoperative corneal edema.]]> 2022/9/2 14:23:10 He Xu, Yue Qu, Yan-Cai Liu, Xiao-Bin Jing and Shu-Yan Wang 21true METHODS: PubMed, Embase, Web of Science and Cochrane Library databases were searched for publications from 1 January, 2011 to 5 January, 2021 on OCTA analysis of VD in different regions of the macular area in diabetic patients with NDR. Compare the differences in the superficial parafoveal VD(spafVD), superficial perifoveal VD(spefVD), deep parafoveal VD(dpafVD), deep perifoveal vessel density(dpefVD), superficial FAZ area and best corrected visual acuity(BCVA)between NDR group and the normal control group(healthy population matched for the age at the same time and gender with patients in the NDR group).

RESULTS: Thirteen publications with a total of 1 227 eyes(558 eyes in normal control group and 669 eyes in NDR group)were included in the study. Meta-analysis showed that compared with the control group, NDR group displayed a significant decrease in spafVD(MD=-1.90, 95%CI: -2.43--1.37, P<0.00001), spefVD(MD=-1.29, 95%CI: -2.14--0.44, P=0.003), dpafVD(MD=-2.18, 95%CI: -2.69--1.67, P<0.00001)and dpefVD(MD=-2.37, 95%CI: -3.27--1.46, P<0.00001), with a more significant reduction in dpefVD, and superficial FAZ area(MD=0.04, 95%CI: 0.03-0.06, P<0.00001)was increased. There was no difference in BCVA(MD=0.00, 95%CI: -0.01-0.02, P=0.44)between the two groups.

CONCLUSION:Capillary injury in the deep perifoveal region of the macular area is the earliest manifestation of retinal microcirculation disturbance in diabetic patients, and is also a key indicator for clinical follow-up of diabetic retinopathy.]]> 2022/9/2 14:23:10 Dan-Dan Liu, Rui Shi, Yuan He, Xiao-Yu Gong, Yao Lu and Jie Yang 20true METHODS: Systematic search of the National Library of America Medical Literature Search System(PubMed), the Excerpta Medica Database(EMBASE), the Cochrane Library and the US Clinical Trial Registry which all literatures established of the database from September 2021. The rate of recurrence, corneal epithelial healing time, the change in Schirmer Ⅰ test(SⅠt)and the change in tear break-up time(BUT)were analyzed. Statistical analysis was performed using Review Manager 5.3, count data were expressed as relative ratio(RR),measurement data were expressed as standardized mean difference(SMD)with 95%CI.

RESULTS: There were 15 studies included with a total number of 1 883 surgical eyes,among them, there were 897 eyes experienced LCAG while 986 eyes underwent CAG. For the rate of recurrence, LCAG group was lower than CAG group(RR=0.33, 95%CI: 0.15-0.71, P=0.004). For corneal epithelial healing time, LCAG group seemed to behave better than CAG group(SMD=-0.87, 95%CI: -1.64 to -0.11, P = 0.02). No statistical significance was found for SⅠt(SMD = 0.03, 95% CI, -0.33-0.40, P=0.86)and as for BUT, LACG group showed longer times against CAG group(SMD=0.40, 95%CI: 0.09-0.70, P=0.01).

CONCLUSIONS: Pterygium resection combined with LCAG was with lower recurrence rate, faster corneal epithelial healing and more stable tear film rather than CAG.]]> 2022/7/27 16:29:04 Ben-Hao Song, Yi-Ru Jin and Zi-Pei Jiang 19true METHODS: Evidence-based medicine research. A systematic database search was conducted Medline, Embase, Web of Science, the Cochrane Register of Controlled Trials and so on from August 2011 to August 2021. Related studies meeting the inclusion criteria were included in our study. The main outcome measures were as follows: success rate and postoperative deviation. Mean difference(MD)and odds ratio(OR)with 95% confidence interval(CI)were statistical analyzed as measurement data and continuous variables statistics.

RESULTS: A total of two randomized controlled studies and five retrospective studies were included. The Meta-analysis results showed that the success rate of surgery was similar for RP group compared with RR group(OR=0.65, 95%CI:0.39-1.07, P=0.09). There was no difference in the incidence of poor postoperative prognosis of the two groups(the undercorrection and overcorrection rates)(OR=1.59; 95%CI: 0.92-2.74, P=0.10; OR=4.43; 95%CI: 0.69-28.18, P=0.12). There were no significant differences in postoperative deviation and the amount of external oblique drift(MD=0.75, 95%CI: -0.27-1.76, P=0.15; MD=-0.34, 95%CI: -1.30-0.63, P=0.50).

CONCLUSION: The success rate of RP and RR surgery is close to the incidence of poor postoperative prognosis, moreover, there was no significant difference between the deviation and the amount of external oblique drift after the two surgeries, RP is an effective surgical procedure for the treatment of exotropia.]]> 2022/7/27 16:29:05 *, Hui Li^*, Jing Qian and Zhi-Jun Chen]]> De-Sheng Song^*, Hui Li^*, Jing Qian and Zhi-Jun Chen 18true METHODS: The PubMed, Embase and Web of Science database were searched from January 2010 to June 2021. A random effects model was used to combine the results, and the sensitivity analysis was performed to determine the stability and reliability of the arithmetic results, and subgroup analysis was used to identify possible sources of heterogeneity.

RESULTS: A total of 25 case-control studies were included. IL-8 levels in patients with DR were significantly higher than those in patients without DR(SMD: 1.57, 95%CI: 1.19-1.95, P<0.01). Sensitivity analysis shows that the calculation results of random effects are stable and reliable. Subgroup analysis based on test method, region, sample source, and type of DR showed that the choice of these factors greatly influenced the relationship between IL-8 levels and patients with DR. Among them, the samples from Bead-based multivariate analysis(I ²=18%, P=0.27), Europe(I ²=38%, P=0.17)and nonproliferative diabetic retinopathy(NPDR)(I ²=0%, P=0.49)showed good consistency. ELISA, American, Asian, vitreous fluid, proliferative diabetic retinopathy(PDR)and other factors may increase the effect size.

CONCLUSION: Elevated IL-8 levels in aqueous eye solution are associated with the risk of DR, and IL-8 may serve as a potential predictor or therapeutic target for DR.]]> 2022/5/30 15:27:45 Bao-Hua Li, Bo-Biao Ning, Fan Yang and Cheng-Wei Guo 17true METHODS: Embase, PubMed and Cochrane Library data were searched from January 2016 to September 2021 for relevant studies on vessel density in macular area of AD patients. Two researchers independently screened the literature, extracted the data, and evaluated the risk of inclusion bias using Newcastle-Ottawa Scale(NOS). Meta-analysis was performed using RevMan 5.3 software.

RESULTS: A total of 740 cases(eyes)were included in 10 literatures, including 321 cases from the AD group and 419 cases from the control group(age-matched people with normal cognitive abilities). The results of the Meta-analysis showed that the superficial vessel density in macular area of AD patients was lower than that in control group(MD=-1.58, 95%CI -2.60- -0.55, P=0.003). The deep vessel density in macular area of AD patients was lower than that in control group(MD=-2.72, 95%CI -4.36- -1.07, P=0.001). The parafoveal vessel density in AD patients was lower than that in control group(MD=-1.44, 95%CI -1.94- -0.94, P<0.00001). The avascular area in the fovea of AD patients was slightly larger than that of the control group(MD=0.05, 95%CI -0.01-0.11, P=0.13).

CONCLUSION: The vessel density of each layer in macular area of AD patients were lower than that of control groups the difference was statistically significant. OCTA can assist in the early diagnosis of AD.]]> 2022/5/30 15:27:45 Yu Deng, Zi-Qiang Liu, Jian-Wei Wang, Yuan-Yuan Li and Chuan-Hong Jie 16true METHODS:Using “Loratadine” “Diclofenac sodium” and “allergic conjunctivitis” as keywords, a randomized controlled trial of Loratadine combined with diclofenac sodium in the treatment of allergic conjunctivitis was searched in Embase, Cochrane library, Pubmed, CNKI, Wanfang database, VIP and SionMed. The retrieval time is from the establishment of the database to July 2021. The risk bias tool provided by the Cochrane cooperation scale was used to assess the risk bias of included studies of RCTs. The publication bias of the included studies was assessed by the Egger's test. Meta-analysis of clinical efficiency, incidence of adverse effects, ocular itch score, and discharge score were using RevMan 5.3. Descriptive analysis were performed on the results with high heterogeneity.

RESULTS:A total of 19 articles were included, all of which were Chinese literatures, including 1 931 patients(2 044 eyes). The control group was treated with Loratadine, and the experimental group was treated with Loratadine combined with Diclofenac sodium eye drops. The Meta-analysis showed that the clinical effect of experimental group was better than control group(OR=4.43, 95%CI:3.26-6.03,P<0.00001).The incidence of adverse reaction was lower than control group(OR=0.32, 95%CI:0.2-0.52,P<0.00001). The Score of ocular itching(MD=-0.36, 95%CI:-0.39 to -0.33,P<0.00001)and discharge(MD=-0.24,95%CI: -0.31 to -0.18,P<0.00001)in experimental group was lower than control group. All the studies on hyperemia and edema of conjunctiva, conjunctival papilla or follicle proliferation and foreign body sensation in patients with allergic conjunctivitis showed that the experimental group could significantly reduce the above symptoms(all P<0.05). Egger's test was performed on the total effective rate, the incidence of adverse reaction. The results showed that there was publication bias in the total effective. Trim and fill method showed that the publication bias did not affect the results.

CONCLUSION: On the basis of the oral Loratadine, combined with Diclofenac sodium eye drops has a certain clinical efficacy in the treatment of allergic conjunctivitis, which can improve the clinical symptoms such as ocular itching, foreign body sensation, hyperemia and edema of conjunctiva, and the incidence of adverse reactions is low, which can provide evidence-based basis for the drug treatment of allergic conjunctivitis in the future. However, due to the low intensity of the included research evidence, more multicenter, randomized double-blind clinical trials are needed in the future, so that to improve the evidence intensity.]]> 2022/3/24 15:57:52 Xiao-Zhuang Li, Wen-Jing Yin, Qi-Pei Fan, Feng Liu and Jun-Ji Wu 15true METHODS:Randomized controlled trials(RCTs)and cohort studies comparing the related efficacy of travoprost and timolol for POAG were retrieved from PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure(CNKI), Chinese Biomedical Literature Database(CBM), VIP database and Wanfang database. The search time was from January 1, 2015 to December 31, 2020. The literatures were screened according to the inclusion and exclusion criteria. After quality evaluation by Cochrane tools for RCTs and NOS scores for cohort studies, Review Manager 5.4 software was used for Meta-analyses to generate weighed-mean-difference(WMD)as effect size contrasting the efficacy of travoprost and timolol for the peak systolic velocity(PSV), the end diastolic velocity(EDV)and the resistance index(RI)of the central retinal artery(CRA)and the posterior ciliary artery(PCA), astigmatism, the plasma endothelin-1(ET-1), the serum matrix metalloproteinase(MMP), the tissue inhibitor of metalloproteinase-2(TIMP-2)of the aqueous humor and the serum TIMP-2.

RESULTS:Totally 8 RCTs and 4 retrospective cohort studies were included with 1 192 patients.Meta-analysis showed that:compared with timolol group, the travoprost group had greater effect on increasing the PSV(WMD=2.40, 95%CI: 2.12-2.68, P<0.00001; WMD=3.76, 95%CI: 3.30-4.22, P<0.00001)and the EDV(WMD=0.81, 95%CI: 0.70-0.91, P<0.00001; WMD=0.90, 95%CI: 0.72-1.09, P<0.00001)of the CRA and the PCA as well as on decreasing the RI(WMD=-0.07, 95%CI: -0.10 to -0.04, P<0.00001; WMD=-0.07, 95%CI: -0.08 to -0.05, P<0.00001)of the CRA and the PCA; Travoprost was more effective in decreasing astigmatism(WMD=-1.34, 95%CI: -1.62 to -1.06, P<0.00001); Compared with timolol, travoprost could significantly decrease the plasma ET-1(WMD=-5.14, 95%CI: -7.08 to -3.20, P<0.00001)and the serum MMP(WMD=-12.48, 95%CI: -24.27 to -0.69, P=0.04), while no statistically significant differences were found in the TIMP-2 of the aqueous humor(WMD=-1.40, 95%CI: -5.51-2.71, P=0.51)and the serum TIMP-2(WMD=1.69, 95%CI: -30.03-33.41, P=0.92).

CONCLUSION:Compared with timolol, travoprost was more effective in improving hemodynamic indexes and decreasing astigmatism in the treatment of POAG.]]> 2022/3/24 15:57:52 Wan-Jing Xu, Shu-Hua Ni, Jun Zhao, Juan-Mei Zhang, Shuang Zhao, Ling-Fang Zheng and Yi-Xuan Fu 14true METHODS: According to the Cochrane systematic evaluation method, “gatifloxacin” “levofloxacin” and “acute bacterial conjunctivitis” were used as keywords for literature search in Embase, Cochrane library, Pubmed, Medline, CNKI, Wanfang, VIP and CBMdisc from the establishment of the database to March 1, 2021. Randomized controlled trials(RCTs)gatifloxacin eye drops and levofloxacin eye drops in the treatment of acute bacterial conjunctivitis were included. Cochrane bias risk assessment tool was used to evaluate the quality of the included studies. RevMan5.3 software was used for combined analysis. Egger's test in Stata12 was used to assess publication bias, and the level of evidence was evaluated according to the GRADE system.

RESULTS: A total of 10 RCTs were included in this study with 1 149 patients. The control group was treated with levofloxacin and the experimental group was treated with gatifloxacin. The results of Meta-analysis showed that the clinical effective rate of acute bacterial conjunctivitis in gatifloxacin group was higher than that in levofloxacin group(OR=3.75, 95%CI: 2.52-5.58, P<0.00001). Egger's test suggested there was publication bias among studies. And GRADE rating results indicated, the level of evidence was VERY LOW. The incidence of adverse drug reactions in the gatifloxacin group was lower than that in levofloxacin group(OR=0.37, 95%CI: 0.19-0.71, P=0.003). No publication bias was observed in Egger's test and GRADE showed the level of evidence was LOW.

CONCLUSION: Gatifloxacin eye drops is more effective than levofloxacin eye drops in the treatment of acute bacterial conjunctivitis, and has lower adverse effect rates. And due to the low levels of evidence included, more multicenter, randomized double-blind clinical trials are needed to improve the strength of evidence for the clinical efficacy of gatifloxacin eye drops in the treatment of acute bacterial conjunctivitis.]]> 2022/1/27 16:19:52 Liang Zhou, Xiao-Zhuang Li, Shi-Peng Zou, Lan-Hui Yu and Jing-Lin Yi 13true METHODS: PubMed, Cochrane Library, American Science Citation Index(SCI)Database, China National Knowledge Infrastructure(CNKI), Wanfang Database were searched from the establishment to July 20, 2021 for relevant literatures about the treatment of NVG with AGV implantation and anti-VEGF drugs. These literatures were imported into EndNoteX9, strictly screened according to the inclusion and exclusion criteria and evaluated for their quality, and the raw data were extracted and integrated. STATA 16.0 and RevMan 5.3 were applied for Meta-analysis.

RESULTS: A total of 10 clinical studies with 490 eyes in total were included in Meta-analysis. According to the different research types of these literatures, the quality of the original literatures was evaluated as medium to high, and the homogeneity of the basic data among the studies was excellent. Meta-analysis showed that the intraocular pressure of patients who underwent intravitreous injection of anti-VEGF drugs was significantly decreased 1wk and 1mo after treatment compared with those patients who underwent single AGV implantation. Moreover, AGV implantation combined with intravitreous injection of anti-VEGF drugs could not improve postoperative best corrected visual acuity(BCVA). Although the combination with bevacizumab did not significantly improve the success rate of surgery, it could significantly reduce the amount of anti-glaucoma drugs still needed after surgery, whereas, ranibizumab did the opposite in both success rate and drug amount.

CONCLUSION: Compared with single AGV implantation, the combination of AGV implantation and intravitreous injection of anti-VEGF drugs has advantages in reducing intraocular pressure of NVG patients. According to different anti-VEGF drugs, the combination has some positive effects on increasing the success rate of surgery and reducing the amount of anti-glaucoma drugs still needed after operation.]]> 2022/11/29 14:58:53 Bin Lin, Long-Long Chen and Dong-Kan Li 12true METHODS: Databases, including Wanfang database, CNKI, VIP database, CBM, PubMed, Embase, Cochrane Library and Web of Science, were searched from the establishment to May 2022. A clinical randomized controlled trial(RCT)of TA for the treatment of non-infectious uveitis secondary to macular edema was included, with subconjunctival injection of TA in the trial group and intravitreal injection of triamcinolone acetonide(IVTA)in the control group. Review Manager 5.4 and Stata15 were used for Meta-analysis of the postoperative best corrected visual acuity(BCVA), central macular thickness(CMT), overall efficiency and adverse effects. Odds ratio(OR), weighted mean(MD)and 95% confidence interval(CI)were applied to evaluate.

RESULTS: A total of 8 studies were included. The Meta-analysis showed that subconjunctival injection of TA was better than the IVTA group in improving BCVA(MD=0.81, 95%CI: 0.60～1.01, P<0.0001), reducing CMT(MD=-48.35, 95%CI: -58.82～-37.88, P<0.0001)and in the overall efficiency(OR=3.88, 95%CI: 2.32～6.52, P<0.0001); The incidence of adverse events was lower than that of the IVTA group(OR=0.45, 95%CI: 0.32～0.62, P<0.0001).

CONCLUSION: As for the treatment of non-infectious uveitis, subconjunctival injection of TA was superior to IVTA in terms of its improved visual acuity, reduced CMT, overall efficiency and lower incidence of adverse events.]]> 2022/11/29 14:58:53 Da-Hua Xu, Ting Zhu and Mei Chen 11true METHODS: CNKI, WanFang Data, VIP, CBM, PubMed, and Embase databases were searched for relevant studies. The retrieval time was from the establishment of the database to October 2021. Two investigators independently screened the literature, extracted data and evaluated the quality of the included studies using the NOS scale. Meta-analysis and publication bias evaluation was performed using RevMan 5.3 and STATA, and sensitivity analysis was performed for results with large heterogeneity to ensure the accuracy of the results.

RESULTS: A total of 44 studies, including 2 053 patients(2 600 eyes)with NDR and 1 775 healthy control patients(2 117 eyes), were included. The Meta-analysis was performed on 17 indexes including the area and perimeters of the foveal avascular zone(FAZ), the vascular density(VD)of FAZ-300um(FD300), acircularity index(AI), VD of macular area, ganglion cell complex(GCC)thickness and retinal nerve fiber layer(RNFL)thickness. Meta-analysis results showed that the area and perimeter of FAZ in superficial capillary plexus(SCP)and deep capillary plexus(DCP)in the NDR group were higher than those of healthy control patients, and FD300, VD of macular area and RNFL thickness were all lower than those in the control group(all P<0.05); The AI values in the NDR group were slightly higher than those in the normal control group, and the GCC thickness and VD of peri-optic papillary were lower than those in the control group, but there was no differences between the groups(P>0.05).

CONCLUSIONS: Compared to the healthy control group, NDR patients had increased FAZ area and perimetry, decreased VD of macular area and RNFL thickness and early retinal microvascular damage and neurodegenerative lesions. OCTA could be used as an auxiliary tool for early diagnosis of DR.]]> 2022/10/28 16:28:13 Zi-Qiang Liu, Yu Deng, Chuan-Hong Jie, Jian-Wei Wang, Xiao-Hua Song, Yun-Ru Chen and Yuan-Yuan Li 10true METHODS: Using “olopatadine eye drops”, “pranoprofen eye drops” and “allergic conjunctivitis” as keywords, the controlled clinical trials of olopatadine combined with pranoprofen in the treatment of allergic conjunctivitis were searched from Embase, Cochrane library, PubMed, CNKI, Wanfang and VIP database, with an retrieval time from the establishment of the database to January 1, 2022; The Cochrane Risk of Bias Assessment Tool was used to assess the quality of the included studies, and the Egger's test was performed for publication bias of the included literatures. Meta-analysis was performed by using RevMan 5.3.

RESULTS: A total of 24 eligible Chinese literatures were included, with 2 443 patients(2 547 eyes)in total. The test group was administrated olopatadine combined with pranoprofen, and the control group was treated with olopatadine monotherapy; The results of Meta-analysis showed that the clinical efficiency of the test group was better than that of the control group(OR=4.42, 95%CI:3.37-5.80,P<0.00001); There was no significant difference in the incidence of adverse reactions between the test group and the control group(OR=0.89, 95%CI: 0.45-1.75, P=0.73); Egger's test was conducted on the clinical efficiency and the incidence of adverse reactions, which showed that there was publication bias in the clinical efficiency, but the existed publication bias did not affected results through trim and fill method.

CONCLUSIONS: The combination of olopatadine with pranoprofen may improve the clinical efficacy of allergic conjunctivitis. In the future, multicentered, randomized, double-blind studies can be conducted to improve the strength of the evidence.]]> 2022/10/28 16:28:13 Xiao-Zhuang Li, Wen-Jing Yin, Qi-Pei Fan, Yan Liang, Feng Liu and Jun-Ji Wu 9true METHODS: PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Database, VIP and CBM were searched for all publications related to 0.01%, 0.025% and 0.05% atropine to control myopia simultaneously. The publication time is from the database construction to May 2022. The Cochrane handbook was used to evaluate the risk of bias and quality of the included literature, STATA12.0 was used to detect publication bias and Revman5.4 software was used for Meta-analysis.

RESULTS: A total of 6 literatures(1 239 eyes)were included, with 5 randomized controlled trials and 1 case-control study. Meta-analysis results showed that 0.025% atropine had better inhibitory effect on SE and AL than 0.01% atropine(SE: WMD=-0.15, 95%CI: -0.23--0.06, P<0.001; AL: WMD=0.07, 95%CI: 0.03-0.10, P<0.001). The inhibitory effect of 0.05% atropine on SE and AL was better than 0.01% atropine(SE: WMD=-0.35, 95%CI: -0.44--0.26, P<0.001; AL: WMD=0.16, 95%CI: 0.12-0.20, P<0.001). The inhibitory effect of 0.05% atropine on SE and AL increase was better than 0.025% atropine(SE: WMD=-0.20, 95%CI: -0.28--0.11, P<0.001; AL: WMD=0.09, 95%CI: 0.06-0.12, P<0.001).

CONCLUSION: The concentration of 0.05% atropine is superior to 0.01% and 0.025% atropine in the control of SE and AL. However, the side effects of long-term use remain to be observed.]]> 2022/9/22 16:19:05 Zhi-Ming Gu, Chang-Jun Lan, Wei-Qi Zhong, Xiao-Yu Li, Xiao-Ling Xiang and Xuan Liao 8true METHODS: A total of 8 databases, including Pubmed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Database, VIP Database and China Biomedical Literature Database, were electronically retrieved to collect the clinical randomized controlled trial(RCT)of low-energy red light in myopia, with red light intervention as an experimental group and glasses as a control group. The retrieval time limit is from the establishment of the database to January 2023. According to the recommendation of the Cochrane Handbook, literature quality and risk of bias were evaluated. Revman5.4 software was used for Meta-analysis.

RESULTS: Totally 8 RCT about red-light treatment with myopia were included. The sample size for ChT analysis contained 407 eyes in the red-light group and 425 eyes in the control group; SE analysis included 490 eyes in the red-light group and 518 eyes in the control group; sample size for AL analysis were 518 eyes in the red-light group and 539 eyes in the control group. The differences in ChT, SE and AL between the groups were statistically significant(ChT: WMD=37.81, 95%CI: 21.55～54.07, P<0.001; SE: WMD=0.58, 95%CI: 0.46～0.71, P<0.001; AL: WMD=-0.31, 95%CI: -0.39～-0.24, P<0.001).

CONCLUSION: Specific red light can promote the increase of ChT while inhibit SE and AL. However, its long-term efficacy and side effects remain unclear. The above conclusions need to be further clarified by more RCT with large samples.]]> 2023/4/27 14:33:10 Zhi-Ming Gu, Chang-Jun Lan, Wei-Qi Zhong, Gui-Mei Zhou and Xuan Liao 7true METHODS: PubMed, Web of Science, EMBASE, Cochrane and CNKI, VIP, CBM, and Wan Fang Data were searched for clinically controlled studies from January 2010 to August 2022, including an experimental group with cyclotorsion compensation during SMILE and a control group without cyclotorsion compensation during SMILE. After literature screening, quality evaluation, and data extraction by two researchers independently, the Meta-analysis of uncorrected distance visual acuity(UDVA), residual astigmatism, vector analysis indicators for measuring the astigmatism correction including absolute value of angle of error(|AE|)and magnitude error(ME), and post-operative total higher order aberrations, spherical aberration and coma was carried out with Stata 16.0 software.

RESULTS: Seven studies with a total of 846 eyes(442 in the experimental group, 404 in the control group)were finally included. The Meta-analysis showed that there were significant differences in the percentage of eyes with residual astigmatism ≥1.00D(OR=0.17, 95%CI: 0.06～0.49, P<0.01), |AE|(WMD=-1.56, 95%CI: -2.68～-0.45, P<0.01), the coma(WMD=0.06, 95%CI: -0.08～-0.04, P<0.01), and the total higher order aberrations(WMD=-0.04, 95%CI: -0.06～-0.02, P<0.01). However, there were no differences in the postoperative UDVA(WMD=0.00, 95%CI: -0.02～0.01, P=0.54), residual astigmatism(WMD=0.08, 95%CI: -0.02～0.18, P=0.10), ME(WMD=-0.01, 95%CI: -0.14～0.12, P=0.85), and the spherical aberration(WMD=0.03, 95%CI: -0.07～0.13, P=0.52).

CONCLUSION: Cyclotorsion compensation in SMILE can reduce the angular error caused by eye rotation during astigmatism correction. It also decreases postoperative residual astigmatism. Overall, the SMILE with cyclotorsion compensation is superior in clinical efficacy of the precise correction of astigmatism.]]> 2023/4/27 14:33:10 Zhi-Feng Lu, Zi-Chen Wang, Jia-Jun Lu, Jia-Jia Zhou, Ying Yu and Shu Liang 6true METHODS: Chinese and English databases such as Chinese national knowledge infrastructure(CNKI), Wanfang, VIP, CBM, ClinicalTrials, PubMed, Embase and Web of Science were searched, and clinical randomized controlled trials(RCTs)using IPL combined with MGX in the experimental group and MGX alone in the control group from January 2017 to September 2022 were included. Six outcome indicators including clinical efficacy, ocular surface disease index(OSDI)score, break-up time(BUT), corneal fluorescein staining(CFS)score, tear meniscus height(TMH)and meibomian gland yielding secretion score(MGYSS)were Meta analyzed by Review Manager 5.3 and Stata 14 software.

RESULTS: A total of 15 RCTs were included, with 1 345 patients with MGD-related dry eye. Meta-analysis results showed that the treatment of MGD-related dry eye in the experimental group improved better clinical efficacy(OR=4.95, 95%CI: 2.76～8.90, Z=5.35, P<0.00001), BUT(SMD=1.26, 95%CI: 0.84～1.69, Z=5.78, P<0.00001), TMH(SMD=0.37, 95%CI: 0.15～0.59, Z=3.33, P=0.0009), and reduced OSDI scores(SMD=-0.86, 95%CI: -1.44～-0.27, Z=2.85, P=0.004)as well as MGYSS(SMD=-2.43, 95%CI: -4.31～-0.54, Z=2.52, P=0.01)than the control group. However, there was no statistically significant difference in CFS scores(SMD=-0.19, 95%CI: -0.46～0.07, Z=1.43, P=0.15).

CONCLUSION: IPL combined with MGX in the treatment of MGD related dry eye can increase the overall effective rate and improve the symptoms and signs of patients with MGD related dry eye better than MGX alone.]]> 2023/3/30 16:29:52 Yu Huang, Jie Li, Dong-Dong Li, Jia-Hui Sun, Xin Xia and Qing-Hua Peng 5true METHODS: Databases including Wanfang database, China National Knowledge Infrastructure(CNKI), PubMed, EMbase, China Biomedical Document Service System(CBM), Clinicalkey, and Cochrane Library were retrieved. Literatures about intravitreal ranibizumab combined with compound trabeculectomy and PRP in the treatment of NVG in the experimental group and compound trabeculectomy and PRP in the treatment of NVG in the control group from creation of database to July 20, 2022 were searched. At the same time, relevant reference were consulted. The best corrected visual acuity, intraocular pressure, occurrence of complications and the success rate of the surgery were systematically evaluated.

RESULTS: A total of 8 clinical studies were included, with 864 patients(864 eyes)with NVG. Meta-analysis showed that the intraocular pressure of patients in the experimental group was lower than that in the control group at 1wk, 1 and 3mo after surgery(1wk: MD=-4.00, 95%CI: -4.62～-3.38, P<0.05; 1mo: MD=-4.11, 95%CI: -4.66～-3.56, P<0.05; 3mo: MD=-4.58, 95%CI: -5.61～-3.55, P<0.05). The best corrected visual acuity of the experimental group was better than that of the control group at 1mo after surgery(MD=0.17, 95%CI: 0.11～0.23, P<0.05), but there was no significant difference at 1wk after surgery(MD=0.08, 95%CI: -0.13～0.29, P=0.47). The patients in the experimental group had fewer complications(OR=0.30, 95%CI: 0.18～0.52, P<0.05)and higher surgical success rate(OR=5.15, 95%CI: 2.78～9.53, P<0.05).

CONCLUSION:With decreased intraocular pressure, improved visual acuity and surgical success rate, intravitreal ranibizumab combined with compound trabeculectomy and PRP was better than the compound trabeculectomy and PRP in the treatment of NVG.]]> 2023/3/30 16:29:52 Xiao-Lan Zhao, Hong-Yu Zhu, Yan-Ni Dai and Xiao-Li Yang 4true 2023/3/2 16:43:36 Wan-Xuan Chai, Zhi-Peng You, Han-Ying Hu, Yong-Ji Zhao and Xiao-Han Su 3true METHODS: PubMed, Web of Science, Cochrane Library, Embase, Chinese Bio-Medical Literature Database, CNKI, VIP, and Wan Fang Database were retrieved. Randomized controlled trials related to the treatment of dry eye with 0.05%CsA from January 1, 2016 to March 28, 2022 in each database were included. The CsA group was treated with 0.05% CsA eye drops, and the control group was treated with artificial tears and placebo. ReMan 5.3 was used for Meta-analysis of post-treatment Schirmer Ⅰ test(SⅠt), break up time(BUT), corneal fluorescein staining(CFS), ocular surface disease index(OSDI)and adverse effects.

RESULTS: A total of 13 literatures were included, which included 1 164 cases(2 057 eyes). Compared with the control group, the SIt in the CsA group was prolonged(MD=2.04, 95%CI: 1.75～2.33, P<0.00001), BUT was longer(MD=1.32, 95%CI: 0.87～1.76, P<0.00001), CFS decreased(MD=-0.79, 95%CI: -1.20～-0.39, P=0.0001)and OSDI decreased(MD=-5.52, 95%CI: -9.14～-1.91, P=0.003). However, the CsA group had more adverse reactions(OR=1.69, 95%CI: 1.06～2.72, P=0.03).

CONCLUSION: 0.05% CsA can improve the subjective symptoms and various objective indicators of dry eye patients. However, 0.05% CsA seems to produce more adverse effects, like ocular burning sensation when compared to drugs such as artificial tears.]]> 2023/2/2 16:41:47 Xiao-Hui Tian, Lu-Mei Hu, Xiang-Long Yi and Hong Zhang 2true METHODS: Randomized controlled trials(RCT)in PubMed, the Cochrane Library, Embase, CNKI, VIP and WanFang Data databases were retrieved from the creation to May 2022. The quality of the included literature was evaluated by using the bias risk evaluation tool in Cochrane Intervention System Evaluation Manual. Meta-analysis was carried out via Review Manager 5.4.

RESULTS: A total of 14 RCT studies, involving 3 946 children and adolescents. Meta-analysis showed that compared with the control group, atropine eye drops with different concentrations could delay the progression of myopia in children and adolescents. The growth of axial length of the groups with 1%, 0.5%, 0.05%, 0.02% and 0.01% atropine eye drops respectively was lower than that of the control group, the difference was statistically significant(MD=-0.34, 95%CI:-0.39～-0.29, P<0.00001; MD=-0.51, 95%CI:-0.79～-0.24, P=0.0003; MD=-0.17, 95%CI:-0.30～-0.04, P=0.01; MD=-0.21, 95%CI:-0.30～-0.11, P<0.0001; MD=-0.09, 95%CI:-0.13～-0.05, P<0.0001), while the growth of axial length of group with 0.1% atropine eye drops was lower than that of control group, the difference was not statistically significant(MD=-0.50, 95%CI:-1.28～0.28, P=0.21).

CONCLUSION: Atropine eye drops with different concentrations can effectively delay the progression of myopia in children and adolescents, while 0.01% can delay the progression of myopia with the lowest incidence of adverse reactions.]]> 2023/1/4 15:06:21 Song-Yu Li, Ying-Xin Yang, Chao Yang, Zi-Yi Yang, Yu-Xin Xue and Jing-Hua Feng 1true